17 β -Estradiol Regulates Microglia Activation and Polarization in the Hippocampus Following Global Cerebral Ischemia

17 -Estradiol (E2) is a well-known neuroprotective hormone, but its role in regulation of neuroinflammation is less understood. Recently, our lab demonstrated that E2 could regulate the NLRP3 (NOD-like receptor protein 3) inflammasome pathway in the hippocampus following global cerebral ischemia (GC...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2018, Vol.2018 (1), p.4248526
Hauptverfasser:	Thakkar, Roshni, Wang, Ruimin, Wang, Jing, Vadlamudi, Ratna K, Brann, Darrell W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Ischemia - drug therapy Brain Ischemia - metabolism Brain Ischemia - pathology Estradiol - metabolism Estradiol - pharmacology Female Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Microglia - drug effects Microglia - metabolism Microglia - pathology Rats Rats, Sprague-Dawley
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