Analysis of the Damage Mechanism Related to CO 2 Laser Cochleostomy on Guinea Pig Cochlea
Different types of lasers have been used in inner ear surgery. Therefore, it is of the utmost importance to avoid damage to the inner ear (e.g., hyperthermia and acoustic effects) caused by the use of such lasers. The aim of this study was to use a high powered fibre-enabled CO laser (10 W, 606 J/cm...
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| Veröffentlicht in: | Neural plasticity 2016, Vol.2016, p.5982397-8 |
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| creator | Liu, Xiang Qian, Xiao-Qing Ma, Rui Chi, Fang-Lu Ren, Dong-Dong |
| description | Different types of lasers have been used in inner ear surgery. Therefore, it is of the utmost importance to avoid damage to the inner ear (e.g., hyperthermia and acoustic effects) caused by the use of such lasers. The aim of this study was to use a high powered fibre-enabled CO
laser (10 W, 606 J/cm
) to perform cochleostomies on guinea pig cochlea and to investigate the possible laser-induced damage mechanisms. The temperature changes in the round window membrane, auditory evoked brainstem response, and morphological of the hair cells were measured and recorded before and after laser application. All of the outcomes differed in comparison with the control group. A rise in temperature and subsequent increased hearing loss were observed in animals that underwent surgery with a 10 W CO
laser. These findings correlated with increased injury to the cochlear ultrastructure and a higher positive expression of E-cadherin and
-catenin in the damaged organ of Corti. We assume that enhanced cell-cell adhesion and the activated
-catenin-related canonical Wnt-signalling pathway may play a role in the protection of the cochlea to prevent further damage. |
| doi_str_mv | 10.1155/2016/5982397 |
| format | Article |
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laser (10 W, 606 J/cm
) to perform cochleostomies on guinea pig cochlea and to investigate the possible laser-induced damage mechanisms. The temperature changes in the round window membrane, auditory evoked brainstem response, and morphological of the hair cells were measured and recorded before and after laser application. All of the outcomes differed in comparison with the control group. A rise in temperature and subsequent increased hearing loss were observed in animals that underwent surgery with a 10 W CO
laser. These findings correlated with increased injury to the cochlear ultrastructure and a higher positive expression of E-cadherin and
-catenin in the damaged organ of Corti. We assume that enhanced cell-cell adhesion and the activated
-catenin-related canonical Wnt-signalling pathway may play a role in the protection of the cochlea to prevent further damage.</description><identifier>ISSN: 2090-5904</identifier><identifier>EISSN: 1687-5443</identifier><identifier>DOI: 10.1155/2016/5982397</identifier><identifier>PMID: 28070426</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Brain Stem - pathology ; Brain Stem - physiopathology ; Cochlea - pathology ; Cochlea - physiopathology ; Cochlea - surgery ; Evoked Potentials, Auditory, Brain Stem - physiology ; Guinea Pigs ; Hearing Loss - etiology ; Hearing Loss - pathology ; Hearing Loss - physiopathology ; Lasers, Gas - adverse effects ; Male</subject><ispartof>Neural plasticity, 2016, Vol.2016, p.5982397-8</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1036-2da4ad0e2dc7ba8596064a80ca8cf85c3714a734e7b8812230ef0c4f4ffd329f3</citedby><cites>FETCH-LOGICAL-c1036-2da4ad0e2dc7ba8596064a80ca8cf85c3714a734e7b8812230ef0c4f4ffd329f3</cites><orcidid>0000-0002-3243-0393 ; 0000-0002-2889-9375</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28070426$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Xiang</creatorcontrib><creatorcontrib>Qian, Xiao-Qing</creatorcontrib><creatorcontrib>Ma, Rui</creatorcontrib><creatorcontrib>Chi, Fang-Lu</creatorcontrib><creatorcontrib>Ren, Dong-Dong</creatorcontrib><title>Analysis of the Damage Mechanism Related to CO 2 Laser Cochleostomy on Guinea Pig Cochlea</title><title>Neural plasticity</title><addtitle>Neural Plast</addtitle><description>Different types of lasers have been used in inner ear surgery. Therefore, it is of the utmost importance to avoid damage to the inner ear (e.g., hyperthermia and acoustic effects) caused by the use of such lasers. The aim of this study was to use a high powered fibre-enabled CO
laser (10 W, 606 J/cm
) to perform cochleostomies on guinea pig cochlea and to investigate the possible laser-induced damage mechanisms. The temperature changes in the round window membrane, auditory evoked brainstem response, and morphological of the hair cells were measured and recorded before and after laser application. All of the outcomes differed in comparison with the control group. A rise in temperature and subsequent increased hearing loss were observed in animals that underwent surgery with a 10 W CO
laser. These findings correlated with increased injury to the cochlear ultrastructure and a higher positive expression of E-cadherin and
-catenin in the damaged organ of Corti. We assume that enhanced cell-cell adhesion and the activated
-catenin-related canonical Wnt-signalling pathway may play a role in the protection of the cochlea to prevent further damage.</description><subject>Animals</subject><subject>Brain Stem - pathology</subject><subject>Brain Stem - physiopathology</subject><subject>Cochlea - pathology</subject><subject>Cochlea - physiopathology</subject><subject>Cochlea - surgery</subject><subject>Evoked Potentials, Auditory, Brain Stem - physiology</subject><subject>Guinea Pigs</subject><subject>Hearing Loss - etiology</subject><subject>Hearing Loss - pathology</subject><subject>Hearing Loss - physiopathology</subject><subject>Lasers, Gas - adverse effects</subject><subject>Male</subject><issn>2090-5904</issn><issn>1687-5443</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90L1OwzAUhmELgWgpbMzIF0Dg-N8ZqwAFqagIwcAUnTp2G5TEVZwOvXuoWpjOcF59w0PINYM7xpS658D0vcotF7k5IWOmrcmUlOKUjDnkkKkc5IhcpPQNILVS6pyMuAUDkusx-Zp22OxSnWgMdFh7-oAtrjx99W6NXZ1a-u4bHHxFh0iLBeV0jsn3tIhu3fiYhtjuaOzobFt3HulbvTq-8JKcBWySvzreCfl8evwonrP5YvZSTOeZYyB0xiuUWIHnlTNLtCrXoCVacGhdsMoJwyQaIb1ZWss4F-ADOBlkCJXgeRATcnvYdX1Mqfeh3PR1i_2uZFDuhcq9UHkU-s1vDvlmu2x99R__kYgfSPpfNw</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Liu, Xiang</creator><creator>Qian, Xiao-Qing</creator><creator>Ma, Rui</creator><creator>Chi, Fang-Lu</creator><creator>Ren, Dong-Dong</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-3243-0393</orcidid><orcidid>https://orcid.org/0000-0002-2889-9375</orcidid></search><sort><creationdate>2016</creationdate><title>Analysis of the Damage Mechanism Related to CO 2 Laser Cochleostomy on Guinea Pig Cochlea</title><author>Liu, Xiang ; Qian, Xiao-Qing ; Ma, Rui ; Chi, Fang-Lu ; Ren, Dong-Dong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1036-2da4ad0e2dc7ba8596064a80ca8cf85c3714a734e7b8812230ef0c4f4ffd329f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Brain Stem - pathology</topic><topic>Brain Stem - physiopathology</topic><topic>Cochlea - pathology</topic><topic>Cochlea - physiopathology</topic><topic>Cochlea - surgery</topic><topic>Evoked Potentials, Auditory, Brain Stem - physiology</topic><topic>Guinea Pigs</topic><topic>Hearing Loss - etiology</topic><topic>Hearing Loss - pathology</topic><topic>Hearing Loss - physiopathology</topic><topic>Lasers, Gas - adverse effects</topic><topic>Male</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Xiang</creatorcontrib><creatorcontrib>Qian, Xiao-Qing</creatorcontrib><creatorcontrib>Ma, Rui</creatorcontrib><creatorcontrib>Chi, Fang-Lu</creatorcontrib><creatorcontrib>Ren, Dong-Dong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Neural plasticity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Xiang</au><au>Qian, Xiao-Qing</au><au>Ma, Rui</au><au>Chi, Fang-Lu</au><au>Ren, Dong-Dong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of the Damage Mechanism Related to CO 2 Laser Cochleostomy on Guinea Pig Cochlea</atitle><jtitle>Neural plasticity</jtitle><addtitle>Neural Plast</addtitle><date>2016</date><risdate>2016</risdate><volume>2016</volume><spage>5982397</spage><epage>8</epage><pages>5982397-8</pages><issn>2090-5904</issn><eissn>1687-5443</eissn><abstract>Different types of lasers have been used in inner ear surgery. Therefore, it is of the utmost importance to avoid damage to the inner ear (e.g., hyperthermia and acoustic effects) caused by the use of such lasers. The aim of this study was to use a high powered fibre-enabled CO
laser (10 W, 606 J/cm
) to perform cochleostomies on guinea pig cochlea and to investigate the possible laser-induced damage mechanisms. The temperature changes in the round window membrane, auditory evoked brainstem response, and morphological of the hair cells were measured and recorded before and after laser application. All of the outcomes differed in comparison with the control group. A rise in temperature and subsequent increased hearing loss were observed in animals that underwent surgery with a 10 W CO
laser. These findings correlated with increased injury to the cochlear ultrastructure and a higher positive expression of E-cadherin and
-catenin in the damaged organ of Corti. We assume that enhanced cell-cell adhesion and the activated
-catenin-related canonical Wnt-signalling pathway may play a role in the protection of the cochlea to prevent further damage.</abstract><cop>United States</cop><pmid>28070426</pmid><doi>10.1155/2016/5982397</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3243-0393</orcidid><orcidid>https://orcid.org/0000-0002-2889-9375</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Open Access; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Animals Brain Stem - pathology Brain Stem - physiopathology Cochlea - pathology Cochlea - physiopathology Cochlea - surgery Evoked Potentials, Auditory, Brain Stem - physiology Guinea Pigs Hearing Loss - etiology Hearing Loss - pathology Hearing Loss - physiopathology Lasers, Gas - adverse effects Male |
| title | Analysis of the Damage Mechanism Related to CO 2 Laser Cochleostomy on Guinea Pig Cochlea |
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