Synthesis of 11‐(Piperazin‐1‐yl)‐5 H ‐dibenzo[b,e] [1,4]diazepine on Kilo Scale

Synthesis of 11‐(Piperazin‐1‐yl)‐5 H ‐dibenzo[b,e] [1,4]diazepine on Kilo Scale

A synthesis of 11‐(piperazin‐1yl)‐5 H‐dibenzo[b,e][1,4]diazepine on kilo scale without any chromatographic purification step is reported. Key steps involved are Ullmann condensation, catalytic hydrogenation, and catalyzed cyclization.

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Veröffentlicht in:Journal of chemistry 2011-01, Vol.8 (4), p.1747-1749
Hauptverfasser: Kalhapure, Rahul S., Patil, Bhushan P., Jadhav, Mahantesh N., Kawle, Laxmikant A., Wagh, Sanjay B.
Format: Artikel
Sprache:eng
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Zusammenfassung:A synthesis of 11‐(piperazin‐1yl)‐5 H‐dibenzo[b,e][1,4]diazepine on kilo scale without any chromatographic purification step is reported. Key steps involved are Ullmann condensation, catalytic hydrogenation, and catalyzed cyclization.
ISSN:2090-9063
2090-9071
DOI:10.1155/2011/212014