Efficacy of Intra‐arterial Norcantharidin in Suppressing Tumour 14 C‐labelled Glucose Oxidative Metabolism in rat Morris Hepatoma
Norcantharidin is the demethylated form of Cantharidin, which is the active ingredient of the blister beetle, Mylabris, a long used Chinese traditional medicine. Though not well publicised outside China, Norcantharidin is known to possess significant anti‐hepatoma activity, and is relatively free fr...
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| Veröffentlicht in: | HPB surgery 1996-01, Vol.10 (2), p.65-72 |
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| creator | Mack, Peter Ha, Xiao-Fang Cheng, Li-Yao |
| description | Norcantharidin is the demethylated form of Cantharidin, which is the active ingredient of the blister beetle, Mylabris, a long used Chinese traditional medicine. Though not well publicised outside China, Norcantharidin is known to possess significant anti‐hepatoma activity, and is relatively free from side effects. In the present study, glucose oxidation in tumour and liver tissue slices harvested from hepatomabearing animals was quantified by measuring the radioactivity of
14
C‐labelled CO released from
14
C‐glucose in oxygen‐enriched incubation medium. Results were expressed asa tumour/liver ratio. For comparison, treatments with Norcantharidin, Adriamycin and with hepatic artery ligation were studied. The mean tumour/liver ratio was 4.2+2.2 in untreated controls, but dropped significantly to 2.3+0.5 (p |
| doi_str_mv | 10.1155/1996/63403 |
| format | Article |
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14
C‐labelled CO released from
14
C‐glucose in oxygen‐enriched incubation medium. Results were expressed asa tumour/liver ratio. For comparison, treatments with Norcantharidin, Adriamycin and with hepatic artery ligation were studied. The mean tumour/liver ratio was 4.2+2.2 in untreated controls, but dropped significantly to 2.3+0.5 (p<0.05) with intra‐arterial Norcantharidin (0.5 mg/kg) and to 2.3+0.7 (p<0.05) with intra‐arterial Adriamycin (2.4 mg/kg), and to 2.2+0.7 (p<0.05) with hepatic artery ligation. However, with intravenous Adriamycin at 2.4 mg/kg, the mean tumour/liver ratio was reduced to only 3.5+2.0 and was not significantly different from untreated controls. It is concluded that intra‐arterial Norcantharidin is as effective as intraarterial Adriamycin and hepatic artery ligation in suppressing tumour glucose oxidative metabolism. These results imply that Norcantharidin may have a role to play in the chemotherapy ofprimary livercancer.</description><identifier>ISSN: 0894-8569</identifier><identifier>EISSN: 1607-8462</identifier><identifier>DOI: 10.1155/1996/63403</identifier><language>eng</language><ispartof>HPB surgery, 1996-01, Vol.10 (2), p.65-72</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c763-57cfb6d7949a9889c0714ab934a73e5b73b83d81715a3e7430fbb2c11d395f9f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Mack, Peter</creatorcontrib><creatorcontrib>Ha, Xiao-Fang</creatorcontrib><creatorcontrib>Cheng, Li-Yao</creatorcontrib><title>Efficacy of Intra‐arterial Norcantharidin in Suppressing Tumour 14 C‐labelled Glucose Oxidative Metabolism in rat Morris Hepatoma</title><title>HPB surgery</title><description>Norcantharidin is the demethylated form of Cantharidin, which is the active ingredient of the blister beetle, Mylabris, a long used Chinese traditional medicine. Though not well publicised outside China, Norcantharidin is known to possess significant anti‐hepatoma activity, and is relatively free from side effects. In the present study, glucose oxidation in tumour and liver tissue slices harvested from hepatomabearing animals was quantified by measuring the radioactivity of
14
C‐labelled CO released from
14
C‐glucose in oxygen‐enriched incubation medium. Results were expressed asa tumour/liver ratio. For comparison, treatments with Norcantharidin, Adriamycin and with hepatic artery ligation were studied. The mean tumour/liver ratio was 4.2+2.2 in untreated controls, but dropped significantly to 2.3+0.5 (p<0.05) with intra‐arterial Norcantharidin (0.5 mg/kg) and to 2.3+0.7 (p<0.05) with intra‐arterial Adriamycin (2.4 mg/kg), and to 2.2+0.7 (p<0.05) with hepatic artery ligation. However, with intravenous Adriamycin at 2.4 mg/kg, the mean tumour/liver ratio was reduced to only 3.5+2.0 and was not significantly different from untreated controls. It is concluded that intra‐arterial Norcantharidin is as effective as intraarterial Adriamycin and hepatic artery ligation in suppressing tumour glucose oxidative metabolism. These results imply that Norcantharidin may have a role to play in the chemotherapy ofprimary livercancer.</description><issn>0894-8569</issn><issn>1607-8462</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNotkLFOwzAURS0EEqWw8AWekULt2ontEVWlrdTSge7Rs2ODURJHdoLoxsLeb-RLaAHpSme6ZzgI3VJyT2meT6hSxaRgnLAzNKIFEZnkxfQcjYhUPJN5oS7RVUpvhBAhJRuhr7lz3oDZ4-Dwqu0jfH8eIPY2eqjxU4gG2v4Voq98i497Hrou2pR8-4J3QxOGiCnHs-OpBm3r2lZ4UQ8mJIu3H76C3r9bvLE96FD71JwUEXq8CTH6hJe2gz40cI0uHNTJ3vxzjHaP891sma23i9XsYZ0ZUbAsF8bpohKKK1BSKkME5aAV4yCYzbVgWrJKUkFzYFZwRpzWU0NpxVTulGNjdPenNTGkFK0ru-gbiPuSkvLUrzz1K3_7sR9ZGWX3</recordid><startdate>199601</startdate><enddate>199601</enddate><creator>Mack, Peter</creator><creator>Ha, Xiao-Fang</creator><creator>Cheng, Li-Yao</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199601</creationdate><title>Efficacy of Intra‐arterial Norcantharidin in Suppressing Tumour 14 C‐labelled Glucose Oxidative Metabolism in rat Morris Hepatoma</title><author>Mack, Peter ; Ha, Xiao-Fang ; Cheng, Li-Yao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c763-57cfb6d7949a9889c0714ab934a73e5b73b83d81715a3e7430fbb2c11d395f9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mack, Peter</creatorcontrib><creatorcontrib>Ha, Xiao-Fang</creatorcontrib><creatorcontrib>Cheng, Li-Yao</creatorcontrib><collection>CrossRef</collection><jtitle>HPB surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mack, Peter</au><au>Ha, Xiao-Fang</au><au>Cheng, Li-Yao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of Intra‐arterial Norcantharidin in Suppressing Tumour 14 C‐labelled Glucose Oxidative Metabolism in rat Morris Hepatoma</atitle><jtitle>HPB surgery</jtitle><date>1996-01</date><risdate>1996</risdate><volume>10</volume><issue>2</issue><spage>65</spage><epage>72</epage><pages>65-72</pages><issn>0894-8569</issn><eissn>1607-8462</eissn><abstract>Norcantharidin is the demethylated form of Cantharidin, which is the active ingredient of the blister beetle, Mylabris, a long used Chinese traditional medicine. Though not well publicised outside China, Norcantharidin is known to possess significant anti‐hepatoma activity, and is relatively free from side effects. In the present study, glucose oxidation in tumour and liver tissue slices harvested from hepatomabearing animals was quantified by measuring the radioactivity of
14
C‐labelled CO released from
14
C‐glucose in oxygen‐enriched incubation medium. Results were expressed asa tumour/liver ratio. For comparison, treatments with Norcantharidin, Adriamycin and with hepatic artery ligation were studied. The mean tumour/liver ratio was 4.2+2.2 in untreated controls, but dropped significantly to 2.3+0.5 (p<0.05) with intra‐arterial Norcantharidin (0.5 mg/kg) and to 2.3+0.7 (p<0.05) with intra‐arterial Adriamycin (2.4 mg/kg), and to 2.2+0.7 (p<0.05) with hepatic artery ligation. However, with intravenous Adriamycin at 2.4 mg/kg, the mean tumour/liver ratio was reduced to only 3.5+2.0 and was not significantly different from untreated controls. It is concluded that intra‐arterial Norcantharidin is as effective as intraarterial Adriamycin and hepatic artery ligation in suppressing tumour glucose oxidative metabolism. These results imply that Norcantharidin may have a role to play in the chemotherapy ofprimary livercancer.</abstract><doi>10.1155/1996/63403</doi><tpages>8</tpages></addata></record> |
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| source | Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| title | Efficacy of Intra‐arterial Norcantharidin in Suppressing Tumour 14 C‐labelled Glucose Oxidative Metabolism in rat Morris Hepatoma |
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