Metabolic characteristics of oxcarbazepine (®trileptal) and their beneficial implications for enzyme induction and drug interactions

Hepatic oxygenases of the cytochrome P-450 family play a major role in the clearance of various anti-epileptic drugs. These enzymes are susceptible both to induction and to inhibition. Phenytoin, carbamazepine (CBZ), primidone, and phenobarbitone, for instance, are potent enzyme inducers. Other drug...

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Veröffentlicht in:	Behavioural neurology 1990, Vol.3 (1), p.21-30
Hauptverfasser:	Faigle, J W, Menge, G P
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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