Substantia Nigra Output to Prefrontal Cortex Via Thalamus in Monkeys. I. Electrophysiological Identification of Thalamic Relay Neurons
1 Departments of Physiology and 2 Neurosurgery, Shiga University of Medical Science, Ohtsu, Japan Submitted 30 November 2008; accepted in final form 14 August 2009 ABSTRACT A few studies have been performed in primate basal ganglia–thalamo–prefrontal pathways. Nevertheless, their electrophysiologica...
Gespeichert in:
| Veröffentlicht in: | Journal of neurophysiology 2009-11, Vol.102 (5), p.2933-2945 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2945 |
|---|---|
| container_issue | 5 |
| container_start_page | 2933 |
| container_title | Journal of neurophysiology |
| container_volume | 102 |
| creator | Tanibuchi, Ikuo Kitano, Hiroyuki Jinnai, Kohnosuke |
| description | 1 Departments of Physiology and
2 Neurosurgery, Shiga University of Medical Science, Ohtsu, Japan
Submitted 30 November 2008;
accepted in final form 14 August 2009
ABSTRACT
A few studies have been performed in primate basal ganglia–thalamo–prefrontal pathways. Nevertheless, their electrophysiological properties and anatomical arrangements remain obscure. This study examined them in nigro-thalamo-cortical pathways from the substantia nigra pars reticulata (SNr) to the frontal cortex (FRC) via the mediodorsal (MD) and ventral anterior (VA) thalamus in monkeys. First, single thalamocortical neurons with SNr input were identified by antidromic responses to FRC stimulation and by inhibitory orthodromic responses with short latencies ( |
| doi_str_mv | 10.1152/jn.91287.2008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1152_jn_91287_2008</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733614795</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-da04c056c200ef0335af546b719ce83b5032221622c9d25bc8e6300995dd53dc3</originalsourceid><addsrcrecordid>eNpFkMFOGzEQhq2qqAm0x14r39rLLmM73l0fq4hCJAiI0l4tr9ebON2sg-0V7Avw3DhNBKcZjb75R_Mh9JVATgin55s-F4RWZU4Bqg9ommY0I1xUH9EUIPUMynKCTkPYAEDJgX5CEyIKQTnMpujl91CHqPpoFV7alVf4doi7IeLo8J03rXd9VB2eOx_NM_6bqIe16tR2CNj2-Mb1_8wYcrzI8UVndPRutx6DdZ1bWZ32Fo1J0W3qo3U9du1x3Wp8bzo14qUZ0onwGZ20qgvmy7GeoT-_Lh7mV9n17eVi_vM600yQmDUKZhp4odOzpgXGuGr5rKhLIrSpWM2BUUpJQakWDeW1rkzBAITgTcNZo9kZ-n7I3Xn3OJgQ5dYGbbpO9cYNQZaMFWRWCp7I7EBq70JIJuTO263yoyQg9-blppf_zcu9-cR_OyYP9dY07_RRdQJ-HIC1Xa2frDfyTdW4zyJAJZdUMMZeAVVejdI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733614795</pqid></control><display><type>article</type><title>Substantia Nigra Output to Prefrontal Cortex Via Thalamus in Monkeys. I. Electrophysiological Identification of Thalamic Relay Neurons</title><source>MEDLINE</source><source>American Physiological Society</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Tanibuchi, Ikuo ; Kitano, Hiroyuki ; Jinnai, Kohnosuke</creator><creatorcontrib>Tanibuchi, Ikuo ; Kitano, Hiroyuki ; Jinnai, Kohnosuke</creatorcontrib><description>1 Departments of Physiology and
2 Neurosurgery, Shiga University of Medical Science, Ohtsu, Japan
Submitted 30 November 2008;
accepted in final form 14 August 2009
ABSTRACT
A few studies have been performed in primate basal ganglia–thalamo–prefrontal pathways. Nevertheless, their electrophysiological properties and anatomical arrangements remain obscure. This study examined them in nigro-thalamo-cortical pathways from the substantia nigra pars reticulata (SNr) to the frontal cortex (FRC) via the mediodorsal (MD) and ventral anterior (VA) thalamus in monkeys. First, single thalamocortical neurons with SNr input were identified by antidromic responses to FRC stimulation and by inhibitory orthodromic responses with short latencies (<5 ms) to SNr stimulation. Second, single nigrothalamic neurons were found by antidromic responses to stimulation of the portions of the MD and VA where the thalamocortical neurons were recorded. The inhibitory orthodromic responses in the thalamocortical neurons were considered to be monosynaptically induced by nigral stimulation because the latency distribution of the orthodromic responses in the thalamocortical neurons was similar to that of the antidromic responses in the nigrothalamic neurons. Almost all relay neurons in the rostrolateral MD received inhibitory afferents from the caudolateral SNr and projected to the prefrontal area ventral to the principal sulcus, which constituted the densest nigro-thalamo-cortical projections. Meanwhile, neurons in the VA received inhibitory signals from the whole rostrocaudal extent of the SNr and projected to wide regions of the FRC; neurons in its pars magnocellularis mostly projected to different prefrontal areas, while those in its pars parvocellularis projected to motor areas. This report substantiated the topography of thalamocortical neurons monosynaptically receiving inhibitory SNr input and projecting to the FRC in the primate MD and VA at the single-neuron level.
Address for reprint requests and other correspondence: I. Tanibuchi, Department of Physiology, Shiga University of Medical Science, Seta Tsukinowa-cho, Ohtsu, Shiga 520-2192, Japan (E-mail: buchi{at}belle.shiga-med.ac.jp ).</description><identifier>ISSN: 0022-3077</identifier><identifier>EISSN: 1522-1598</identifier><identifier>DOI: 10.1152/jn.91287.2008</identifier><identifier>PMID: 19692504</identifier><language>eng</language><publisher>United States: Am Phys Soc</publisher><subject>Action Potentials - physiology ; Animals ; Biophysics ; Brain Mapping ; Electric Stimulation - methods ; Interneurons - classification ; Interneurons - physiology ; Macaca fascicularis ; Male ; Prefrontal Cortex - physiology ; Reaction Time - physiology ; Substantia Nigra - physiology ; Thalamus - cytology ; Thalamus - physiology</subject><ispartof>Journal of neurophysiology, 2009-11, Vol.102 (5), p.2933-2945</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-da04c056c200ef0335af546b719ce83b5032221622c9d25bc8e6300995dd53dc3</citedby><cites>FETCH-LOGICAL-c391t-da04c056c200ef0335af546b719ce83b5032221622c9d25bc8e6300995dd53dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19692504$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanibuchi, Ikuo</creatorcontrib><creatorcontrib>Kitano, Hiroyuki</creatorcontrib><creatorcontrib>Jinnai, Kohnosuke</creatorcontrib><title>Substantia Nigra Output to Prefrontal Cortex Via Thalamus in Monkeys. I. Electrophysiological Identification of Thalamic Relay Neurons</title><title>Journal of neurophysiology</title><addtitle>J Neurophysiol</addtitle><description>1 Departments of Physiology and
2 Neurosurgery, Shiga University of Medical Science, Ohtsu, Japan
Submitted 30 November 2008;
accepted in final form 14 August 2009
ABSTRACT
A few studies have been performed in primate basal ganglia–thalamo–prefrontal pathways. Nevertheless, their electrophysiological properties and anatomical arrangements remain obscure. This study examined them in nigro-thalamo-cortical pathways from the substantia nigra pars reticulata (SNr) to the frontal cortex (FRC) via the mediodorsal (MD) and ventral anterior (VA) thalamus in monkeys. First, single thalamocortical neurons with SNr input were identified by antidromic responses to FRC stimulation and by inhibitory orthodromic responses with short latencies (<5 ms) to SNr stimulation. Second, single nigrothalamic neurons were found by antidromic responses to stimulation of the portions of the MD and VA where the thalamocortical neurons were recorded. The inhibitory orthodromic responses in the thalamocortical neurons were considered to be monosynaptically induced by nigral stimulation because the latency distribution of the orthodromic responses in the thalamocortical neurons was similar to that of the antidromic responses in the nigrothalamic neurons. Almost all relay neurons in the rostrolateral MD received inhibitory afferents from the caudolateral SNr and projected to the prefrontal area ventral to the principal sulcus, which constituted the densest nigro-thalamo-cortical projections. Meanwhile, neurons in the VA received inhibitory signals from the whole rostrocaudal extent of the SNr and projected to wide regions of the FRC; neurons in its pars magnocellularis mostly projected to different prefrontal areas, while those in its pars parvocellularis projected to motor areas. This report substantiated the topography of thalamocortical neurons monosynaptically receiving inhibitory SNr input and projecting to the FRC in the primate MD and VA at the single-neuron level.
Address for reprint requests and other correspondence: I. Tanibuchi, Department of Physiology, Shiga University of Medical Science, Seta Tsukinowa-cho, Ohtsu, Shiga 520-2192, Japan (E-mail: buchi{at}belle.shiga-med.ac.jp ).</description><subject>Action Potentials - physiology</subject><subject>Animals</subject><subject>Biophysics</subject><subject>Brain Mapping</subject><subject>Electric Stimulation - methods</subject><subject>Interneurons - classification</subject><subject>Interneurons - physiology</subject><subject>Macaca fascicularis</subject><subject>Male</subject><subject>Prefrontal Cortex - physiology</subject><subject>Reaction Time - physiology</subject><subject>Substantia Nigra - physiology</subject><subject>Thalamus - cytology</subject><subject>Thalamus - physiology</subject><issn>0022-3077</issn><issn>1522-1598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFOGzEQhq2qqAm0x14r39rLLmM73l0fq4hCJAiI0l4tr9ebON2sg-0V7Avw3DhNBKcZjb75R_Mh9JVATgin55s-F4RWZU4Bqg9ommY0I1xUH9EUIPUMynKCTkPYAEDJgX5CEyIKQTnMpujl91CHqPpoFV7alVf4doi7IeLo8J03rXd9VB2eOx_NM_6bqIe16tR2CNj2-Mb1_8wYcrzI8UVndPRutx6DdZ1bWZ32Fo1J0W3qo3U9du1x3Wp8bzo14qUZ0onwGZ20qgvmy7GeoT-_Lh7mV9n17eVi_vM600yQmDUKZhp4odOzpgXGuGr5rKhLIrSpWM2BUUpJQakWDeW1rkzBAITgTcNZo9kZ-n7I3Xn3OJgQ5dYGbbpO9cYNQZaMFWRWCp7I7EBq70JIJuTO263yoyQg9-blppf_zcu9-cR_OyYP9dY07_RRdQJ-HIC1Xa2frDfyTdW4zyJAJZdUMMZeAVVejdI</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Tanibuchi, Ikuo</creator><creator>Kitano, Hiroyuki</creator><creator>Jinnai, Kohnosuke</creator><general>Am Phys Soc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20091101</creationdate><title>Substantia Nigra Output to Prefrontal Cortex Via Thalamus in Monkeys. I. Electrophysiological Identification of Thalamic Relay Neurons</title><author>Tanibuchi, Ikuo ; Kitano, Hiroyuki ; Jinnai, Kohnosuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-da04c056c200ef0335af546b719ce83b5032221622c9d25bc8e6300995dd53dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Action Potentials - physiology</topic><topic>Animals</topic><topic>Biophysics</topic><topic>Brain Mapping</topic><topic>Electric Stimulation - methods</topic><topic>Interneurons - classification</topic><topic>Interneurons - physiology</topic><topic>Macaca fascicularis</topic><topic>Male</topic><topic>Prefrontal Cortex - physiology</topic><topic>Reaction Time - physiology</topic><topic>Substantia Nigra - physiology</topic><topic>Thalamus - cytology</topic><topic>Thalamus - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanibuchi, Ikuo</creatorcontrib><creatorcontrib>Kitano, Hiroyuki</creatorcontrib><creatorcontrib>Jinnai, Kohnosuke</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanibuchi, Ikuo</au><au>Kitano, Hiroyuki</au><au>Jinnai, Kohnosuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Substantia Nigra Output to Prefrontal Cortex Via Thalamus in Monkeys. I. Electrophysiological Identification of Thalamic Relay Neurons</atitle><jtitle>Journal of neurophysiology</jtitle><addtitle>J Neurophysiol</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>102</volume><issue>5</issue><spage>2933</spage><epage>2945</epage><pages>2933-2945</pages><issn>0022-3077</issn><eissn>1522-1598</eissn><abstract>1 Departments of Physiology and
2 Neurosurgery, Shiga University of Medical Science, Ohtsu, Japan
Submitted 30 November 2008;
accepted in final form 14 August 2009
ABSTRACT
A few studies have been performed in primate basal ganglia–thalamo–prefrontal pathways. Nevertheless, their electrophysiological properties and anatomical arrangements remain obscure. This study examined them in nigro-thalamo-cortical pathways from the substantia nigra pars reticulata (SNr) to the frontal cortex (FRC) via the mediodorsal (MD) and ventral anterior (VA) thalamus in monkeys. First, single thalamocortical neurons with SNr input were identified by antidromic responses to FRC stimulation and by inhibitory orthodromic responses with short latencies (<5 ms) to SNr stimulation. Second, single nigrothalamic neurons were found by antidromic responses to stimulation of the portions of the MD and VA where the thalamocortical neurons were recorded. The inhibitory orthodromic responses in the thalamocortical neurons were considered to be monosynaptically induced by nigral stimulation because the latency distribution of the orthodromic responses in the thalamocortical neurons was similar to that of the antidromic responses in the nigrothalamic neurons. Almost all relay neurons in the rostrolateral MD received inhibitory afferents from the caudolateral SNr and projected to the prefrontal area ventral to the principal sulcus, which constituted the densest nigro-thalamo-cortical projections. Meanwhile, neurons in the VA received inhibitory signals from the whole rostrocaudal extent of the SNr and projected to wide regions of the FRC; neurons in its pars magnocellularis mostly projected to different prefrontal areas, while those in its pars parvocellularis projected to motor areas. This report substantiated the topography of thalamocortical neurons monosynaptically receiving inhibitory SNr input and projecting to the FRC in the primate MD and VA at the single-neuron level.
Address for reprint requests and other correspondence: I. Tanibuchi, Department of Physiology, Shiga University of Medical Science, Seta Tsukinowa-cho, Ohtsu, Shiga 520-2192, Japan (E-mail: buchi{at}belle.shiga-med.ac.jp ).</abstract><cop>United States</cop><pub>Am Phys Soc</pub><pmid>19692504</pmid><doi>10.1152/jn.91287.2008</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3077 |
| ispartof | Journal of neurophysiology, 2009-11, Vol.102 (5), p.2933-2945 |
| issn | 0022-3077 1522-1598 |
| language | eng |
| recordid | cdi_crossref_primary_10_1152_jn_91287_2008 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Action Potentials - physiology Animals Biophysics Brain Mapping Electric Stimulation - methods Interneurons - classification Interneurons - physiology Macaca fascicularis Male Prefrontal Cortex - physiology Reaction Time - physiology Substantia Nigra - physiology Thalamus - cytology Thalamus - physiology |
| title | Substantia Nigra Output to Prefrontal Cortex Via Thalamus in Monkeys. I. Electrophysiological Identification of Thalamic Relay Neurons |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T04%3A52%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Substantia%20Nigra%20Output%20to%20Prefrontal%20Cortex%20Via%20Thalamus%20in%20Monkeys.%20I.%20Electrophysiological%20Identification%20of%20Thalamic%20Relay%20Neurons&rft.jtitle=Journal%20of%20neurophysiology&rft.au=Tanibuchi,%20Ikuo&rft.date=2009-11-01&rft.volume=102&rft.issue=5&rft.spage=2933&rft.epage=2945&rft.pages=2933-2945&rft.issn=0022-3077&rft.eissn=1522-1598&rft_id=info:doi/10.1152/jn.91287.2008&rft_dat=%3Cproquest_cross%3E733614795%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733614795&rft_id=info:pmid/19692504&rfr_iscdi=true |