Differential Effects of Hypothermia on Early and Late Epileptiform Events After Severe Hypoxia in Preterm Fetal Sheep
Departments of Physiology and Paediatrics, University of Auckland, Auckland, New Zealand Submitted 7 September 2006; accepted in final form 30 October 2006 Moderate cerebral hypothermia is consistently neuroprotective after experimental hypoxia-ischemia; however, its mechanisms remain poorly defined...
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| Veröffentlicht in: | Journal of neurophysiology 2007-01, Vol.97 (1), p.572-578 |
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| container_title | Journal of neurophysiology |
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| creator | Bennet, L Dean, J. M Wassink, G Gunn, A. J |
| description | Departments of Physiology and Paediatrics, University of Auckland, Auckland, New Zealand
Submitted 7 September 2006;
accepted in final form 30 October 2006
Moderate cerebral hypothermia is consistently neuroprotective after experimental hypoxia-ischemia; however, its mechanisms remain poorly defined. Using a model of complete umbilical cord occlusion for 25 min in 0.7 gestation fetal sheep, we examined the effects of cerebral hypothermia (fetal extradural temperature reduced from 39.5 ± 0.2°C to |
| doi_str_mv | 10.1152/jn.00957.2006 |
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Submitted 7 September 2006;
accepted in final form 30 October 2006
Moderate cerebral hypothermia is consistently neuroprotective after experimental hypoxia-ischemia; however, its mechanisms remain poorly defined. Using a model of complete umbilical cord occlusion for 25 min in 0.7 gestation fetal sheep, we examined the effects of cerebral hypothermia (fetal extradural temperature reduced from 39.5 ± 0.2°C to <34°C; mean ± SD), from 90 min to 70 h after the end of the insult, on postocclusion epileptiform activity. In the first 6 h after the end of occlusion, fetal electroencephalographic (EEG) activity was abnormal with a mixture of fast and slow epileptiform transients superimposed on a suppressed background; seizures started a mean of 8 h after occlusion. There was a close correlation between numbers of these EEG transients and subsequent neuronal loss in the striatum after 3 days recovery ( r 2 = 0.65, P = 0.008). Hypothermia was associated with a marked reduction in numbers of epileptiform transients in the first 6 h, reduced amplitude of seizures, and reduced striatal neuronal loss. In conclusion, neuroprotection with delayed, prolonged head cooling after a severe asphyxial insult in the preterm fetus was associated with potent, specific suppression of epileptiform transients in the early recovery phase but not of numbers of delayed seizures.
Address for reprint requests and other correspondence: A. J. Gunn, Dept. of Physiology, Faculty of Medicine and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand (E-mail: aj.gunn{at}auckland.ac.nz )</description><identifier>ISSN: 0022-3077</identifier><identifier>EISSN: 1522-1598</identifier><identifier>DOI: 10.1152/jn.00957.2006</identifier><identifier>PMID: 17093117</identifier><language>eng</language><publisher>United States: Am Phys Soc</publisher><subject>Animals ; Body Temperature - physiology ; Brain - blood supply ; Brain - physiopathology ; Brain Infarction - etiology ; Brain Infarction - physiopathology ; Brain Infarction - therapy ; Cerebrovascular Circulation - physiology ; Corpus Striatum - blood supply ; Corpus Striatum - physiopathology ; Cytoprotection - physiology ; Disease Models, Animal ; Electroencephalography ; Epilepsy - etiology ; Epilepsy - physiopathology ; Epilepsy - therapy ; Female ; Fetal Hypoxia - physiopathology ; Fetus - physiopathology ; Hypothermia, Induced ; Hypoxia, Brain - etiology ; Hypoxia, Brain - physiopathology ; Hypoxia, Brain - therapy ; Hypoxia-Ischemia, Brain - complications ; Hypoxia-Ischemia, Brain - physiopathology ; Nerve Degeneration - etiology ; Nerve Degeneration - physiopathology ; Nerve Degeneration - therapy ; Pregnancy ; Sheep ; Time Factors ; Treatment Outcome</subject><ispartof>Journal of neurophysiology, 2007-01, Vol.97 (1), p.572-578</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-a35c03d47722adcbf05a289fbab2dea47b6a1d0ec26727c32f2f11fd7cc492a63</citedby><cites>FETCH-LOGICAL-c396t-a35c03d47722adcbf05a289fbab2dea47b6a1d0ec26727c32f2f11fd7cc492a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,3028,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17093117$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bennet, L</creatorcontrib><creatorcontrib>Dean, J. M</creatorcontrib><creatorcontrib>Wassink, G</creatorcontrib><creatorcontrib>Gunn, A. J</creatorcontrib><title>Differential Effects of Hypothermia on Early and Late Epileptiform Events After Severe Hypoxia in Preterm Fetal Sheep</title><title>Journal of neurophysiology</title><addtitle>J Neurophysiol</addtitle><description>Departments of Physiology and Paediatrics, University of Auckland, Auckland, New Zealand
Submitted 7 September 2006;
accepted in final form 30 October 2006
Moderate cerebral hypothermia is consistently neuroprotective after experimental hypoxia-ischemia; however, its mechanisms remain poorly defined. Using a model of complete umbilical cord occlusion for 25 min in 0.7 gestation fetal sheep, we examined the effects of cerebral hypothermia (fetal extradural temperature reduced from 39.5 ± 0.2°C to <34°C; mean ± SD), from 90 min to 70 h after the end of the insult, on postocclusion epileptiform activity. In the first 6 h after the end of occlusion, fetal electroencephalographic (EEG) activity was abnormal with a mixture of fast and slow epileptiform transients superimposed on a suppressed background; seizures started a mean of 8 h after occlusion. There was a close correlation between numbers of these EEG transients and subsequent neuronal loss in the striatum after 3 days recovery ( r 2 = 0.65, P = 0.008). Hypothermia was associated with a marked reduction in numbers of epileptiform transients in the first 6 h, reduced amplitude of seizures, and reduced striatal neuronal loss. In conclusion, neuroprotection with delayed, prolonged head cooling after a severe asphyxial insult in the preterm fetus was associated with potent, specific suppression of epileptiform transients in the early recovery phase but not of numbers of delayed seizures.
Address for reprint requests and other correspondence: A. J. Gunn, Dept. of Physiology, Faculty of Medicine and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand (E-mail: aj.gunn{at}auckland.ac.nz )</description><subject>Animals</subject><subject>Body Temperature - physiology</subject><subject>Brain - blood supply</subject><subject>Brain - physiopathology</subject><subject>Brain Infarction - etiology</subject><subject>Brain Infarction - physiopathology</subject><subject>Brain Infarction - therapy</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Corpus Striatum - blood supply</subject><subject>Corpus Striatum - physiopathology</subject><subject>Cytoprotection - physiology</subject><subject>Disease Models, Animal</subject><subject>Electroencephalography</subject><subject>Epilepsy - etiology</subject><subject>Epilepsy - physiopathology</subject><subject>Epilepsy - therapy</subject><subject>Female</subject><subject>Fetal Hypoxia - physiopathology</subject><subject>Fetus - physiopathology</subject><subject>Hypothermia, Induced</subject><subject>Hypoxia, Brain - etiology</subject><subject>Hypoxia, Brain - physiopathology</subject><subject>Hypoxia, Brain - therapy</subject><subject>Hypoxia-Ischemia, Brain - complications</subject><subject>Hypoxia-Ischemia, Brain - physiopathology</subject><subject>Nerve Degeneration - etiology</subject><subject>Nerve Degeneration - physiopathology</subject><subject>Nerve Degeneration - therapy</subject><subject>Pregnancy</subject><subject>Sheep</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0022-3077</issn><issn>1522-1598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EokvhyBX5xC3bsb2JN8eqZCnSSiC1nC3HGTde5QvbaZv_Hre7VS9InGY083tvRnqEfGawZiznF4dhDVDmcs0BijdklWY8Y3m5fUtWAKkXIOUZ-RDCAQBkDvw9OWMSSsGYXJH5m7MWPQ7R6Y5WqTcx0NHS62UaY4u-d5qOA6207xaqh4budURaTa7DKTo7-p5W90ke6KWN6OkN3ie7Z_ljkrqB_vKYFj3dYUwnblrE6SN5Z3UX8NOpnpPfu-r26jrb__z-4-pynxlRFjHTIjcgmo2UnOvG1BZyzbelrXXNG9QbWReaNYCGF5JLI7jlljHbSGM2JdeFOCdfj76TH__MGKLqXTDYdXrAcQ6q2JYcBOT_BVmZC8kES2B2BI0fQ_Bo1eRdr_2iGKinQNRhUM-BqKdAEv_lZDzXPTav9CmBBPAj0Lq79sF5VFO7BDd2492idnPX3eJjTKalVEzlkqupsa_v_kuUHniBxV9gu6do</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Bennet, L</creator><creator>Dean, J. 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J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-a35c03d47722adcbf05a289fbab2dea47b6a1d0ec26727c32f2f11fd7cc492a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Body Temperature - physiology</topic><topic>Brain - blood supply</topic><topic>Brain - physiopathology</topic><topic>Brain Infarction - etiology</topic><topic>Brain Infarction - physiopathology</topic><topic>Brain Infarction - therapy</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Corpus Striatum - blood supply</topic><topic>Corpus Striatum - physiopathology</topic><topic>Cytoprotection - physiology</topic><topic>Disease Models, Animal</topic><topic>Electroencephalography</topic><topic>Epilepsy - etiology</topic><topic>Epilepsy - physiopathology</topic><topic>Epilepsy - therapy</topic><topic>Female</topic><topic>Fetal Hypoxia - physiopathology</topic><topic>Fetus - physiopathology</topic><topic>Hypothermia, Induced</topic><topic>Hypoxia, Brain - etiology</topic><topic>Hypoxia, Brain - physiopathology</topic><topic>Hypoxia, Brain - therapy</topic><topic>Hypoxia-Ischemia, Brain - complications</topic><topic>Hypoxia-Ischemia, Brain - physiopathology</topic><topic>Nerve Degeneration - etiology</topic><topic>Nerve Degeneration - physiopathology</topic><topic>Nerve Degeneration - therapy</topic><topic>Pregnancy</topic><topic>Sheep</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bennet, L</creatorcontrib><creatorcontrib>Dean, J. M</creatorcontrib><creatorcontrib>Wassink, G</creatorcontrib><creatorcontrib>Gunn, A. J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bennet, L</au><au>Dean, J. M</au><au>Wassink, G</au><au>Gunn, A. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Effects of Hypothermia on Early and Late Epileptiform Events After Severe Hypoxia in Preterm Fetal Sheep</atitle><jtitle>Journal of neurophysiology</jtitle><addtitle>J Neurophysiol</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>97</volume><issue>1</issue><spage>572</spage><epage>578</epage><pages>572-578</pages><issn>0022-3077</issn><eissn>1522-1598</eissn><abstract>Departments of Physiology and Paediatrics, University of Auckland, Auckland, New Zealand
Submitted 7 September 2006;
accepted in final form 30 October 2006
Moderate cerebral hypothermia is consistently neuroprotective after experimental hypoxia-ischemia; however, its mechanisms remain poorly defined. Using a model of complete umbilical cord occlusion for 25 min in 0.7 gestation fetal sheep, we examined the effects of cerebral hypothermia (fetal extradural temperature reduced from 39.5 ± 0.2°C to <34°C; mean ± SD), from 90 min to 70 h after the end of the insult, on postocclusion epileptiform activity. In the first 6 h after the end of occlusion, fetal electroencephalographic (EEG) activity was abnormal with a mixture of fast and slow epileptiform transients superimposed on a suppressed background; seizures started a mean of 8 h after occlusion. There was a close correlation between numbers of these EEG transients and subsequent neuronal loss in the striatum after 3 days recovery ( r 2 = 0.65, P = 0.008). Hypothermia was associated with a marked reduction in numbers of epileptiform transients in the first 6 h, reduced amplitude of seizures, and reduced striatal neuronal loss. In conclusion, neuroprotection with delayed, prolonged head cooling after a severe asphyxial insult in the preterm fetus was associated with potent, specific suppression of epileptiform transients in the early recovery phase but not of numbers of delayed seizures.
Address for reprint requests and other correspondence: A. J. Gunn, Dept. of Physiology, Faculty of Medicine and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand (E-mail: aj.gunn{at}auckland.ac.nz )</abstract><cop>United States</cop><pub>Am Phys Soc</pub><pmid>17093117</pmid><doi>10.1152/jn.00957.2006</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Body Temperature - physiology Brain - blood supply Brain - physiopathology Brain Infarction - etiology Brain Infarction - physiopathology Brain Infarction - therapy Cerebrovascular Circulation - physiology Corpus Striatum - blood supply Corpus Striatum - physiopathology Cytoprotection - physiology Disease Models, Animal Electroencephalography Epilepsy - etiology Epilepsy - physiopathology Epilepsy - therapy Female Fetal Hypoxia - physiopathology Fetus - physiopathology Hypothermia, Induced Hypoxia, Brain - etiology Hypoxia, Brain - physiopathology Hypoxia, Brain - therapy Hypoxia-Ischemia, Brain - complications Hypoxia-Ischemia, Brain - physiopathology Nerve Degeneration - etiology Nerve Degeneration - physiopathology Nerve Degeneration - therapy Pregnancy Sheep Time Factors Treatment Outcome |
| title | Differential Effects of Hypothermia on Early and Late Epileptiform Events After Severe Hypoxia in Preterm Fetal Sheep |
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