Quantifying the Ontogeny of Optokinetic and Vestibuloocular Behaviors in Zebrafish, Medaka, and Goldfish
1 Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016; and 2 Departments of Physics and Molecular Biology, Princeton University, Princeton, New Jersey 08544 Submitted 29 March 2004; accepted in final form 20 July 2004 We quantitatively studied...
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| Veröffentlicht in: | Journal of neurophysiology 2004-12, Vol.92 (6), p.3546-3561 |
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| container_title | Journal of neurophysiology |
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| creator | Beck, James C Gilland, Edwin Tank, David W Baker, Robert |
| description | 1 Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016; and 2 Departments of Physics and Molecular Biology, Princeton University, Princeton, New Jersey 08544
Submitted 29 March 2004;
accepted in final form 20 July 2004
We quantitatively studied the ontogeny of oculomotor behavior in larval fish as a foundation for studies linking oculomotor structure and function with genetics. Horizontal optokinetic and vestibuloocular reflexes (OKR and VOR, respectively) were measured in three different species (goldfish, zebrafish, and medaka) during the first month after hatching. For all sizes of medaka, and most zebrafish, Bode plots of OKR (0.0653.0 Hz, ±10°/s) revealed that eye velocity closely followed stimulus velocity (gain > 0.8) at low frequency but dropped sharply above 1 Hz (gain < 0.3 at 3 Hz). Goldfish showed increased gain proportional to size across frequencies. Linearity testing with steps and sinusoids showed excellent visual performance (gain > 0.8) in medaka almost from hatching; but zebrafish and goldfish exhibited progressive improvement, with only the largest equaling medaka performance. Monocular visual stimulation in zebrafish and goldfish produced gains of 0.5 versus |
| doi_str_mv | 10.1152/jn.00311.2004 |
| format | Article |
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Submitted 29 March 2004;
accepted in final form 20 July 2004
We quantitatively studied the ontogeny of oculomotor behavior in larval fish as a foundation for studies linking oculomotor structure and function with genetics. Horizontal optokinetic and vestibuloocular reflexes (OKR and VOR, respectively) were measured in three different species (goldfish, zebrafish, and medaka) during the first month after hatching. For all sizes of medaka, and most zebrafish, Bode plots of OKR (0.0653.0 Hz, ±10°/s) revealed that eye velocity closely followed stimulus velocity (gain > 0.8) at low frequency but dropped sharply above 1 Hz (gain < 0.3 at 3 Hz). Goldfish showed increased gain proportional to size across frequencies. Linearity testing with steps and sinusoids showed excellent visual performance (gain > 0.8) in medaka almost from hatching; but zebrafish and goldfish exhibited progressive improvement, with only the largest equaling medaka performance. Monocular visual stimulation in zebrafish and goldfish produced gains of 0.5 versus <0.1 for the eye viewing a moving versus stationary stimulus pattern but 0.25 versus <0.1 in medaka. Angular VOR appeared much later than OKR, initially at only high accelerations (>200°/s at 0.5 Hz), first in medaka followed by larger (8.11 mm) zebrafish; but it was virtually nonexistent in goldfish. Velocity storage was not observed except for an eye velocity build-up in the largest medaka. In summary, a robust OKR was achieved shortly after hatching in all three species. In contrast, larval fish seem to be unique among vertebrates tested in their lack of significant angular VOR at stages where active movement is required for feeding and survival.
Address for reprint requests and other correspondence: J. C. Beck, Dept. of Physiology and Neuroscience, MSB-442, NYU School of Medicine, 550 First Ave, New York, NY 10016 (E-mail: james.beck{at}med.nyu.edu ).</description><identifier>ISSN: 0022-3077</identifier><identifier>EISSN: 1522-1598</identifier><identifier>DOI: 10.1152/jn.00311.2004</identifier><identifier>PMID: 15269231</identifier><language>eng</language><publisher>United States: Am Phys Soc</publisher><subject>Animals ; Behavior, Animal - physiology ; Carassius auratus ; Danio rerio ; Fishes - physiology ; Freshwater ; Goldfish ; Nystagmus, Physiologic - physiology ; Oryzias ; Oryzias latipes ; Reflex, Vestibulo-Ocular - physiology ; Saccades - physiology ; Vision, Monocular - physiology ; Zebrafish</subject><ispartof>Journal of neurophysiology, 2004-12, Vol.92 (6), p.3546-3561</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-c29e1462ffcf62edaaf683e2c607d1461cb6e52903d96a4150eb4eba10f0fef03</citedby><cites>FETCH-LOGICAL-c462t-c29e1462ffcf62edaaf683e2c607d1461cb6e52903d96a4150eb4eba10f0fef03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15269231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beck, James C</creatorcontrib><creatorcontrib>Gilland, Edwin</creatorcontrib><creatorcontrib>Tank, David W</creatorcontrib><creatorcontrib>Baker, Robert</creatorcontrib><title>Quantifying the Ontogeny of Optokinetic and Vestibuloocular Behaviors in Zebrafish, Medaka, and Goldfish</title><title>Journal of neurophysiology</title><addtitle>J Neurophysiol</addtitle><description>1 Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016; and 2 Departments of Physics and Molecular Biology, Princeton University, Princeton, New Jersey 08544
Submitted 29 March 2004;
accepted in final form 20 July 2004
We quantitatively studied the ontogeny of oculomotor behavior in larval fish as a foundation for studies linking oculomotor structure and function with genetics. Horizontal optokinetic and vestibuloocular reflexes (OKR and VOR, respectively) were measured in three different species (goldfish, zebrafish, and medaka) during the first month after hatching. For all sizes of medaka, and most zebrafish, Bode plots of OKR (0.0653.0 Hz, ±10°/s) revealed that eye velocity closely followed stimulus velocity (gain > 0.8) at low frequency but dropped sharply above 1 Hz (gain < 0.3 at 3 Hz). Goldfish showed increased gain proportional to size across frequencies. Linearity testing with steps and sinusoids showed excellent visual performance (gain > 0.8) in medaka almost from hatching; but zebrafish and goldfish exhibited progressive improvement, with only the largest equaling medaka performance. Monocular visual stimulation in zebrafish and goldfish produced gains of 0.5 versus <0.1 for the eye viewing a moving versus stationary stimulus pattern but 0.25 versus <0.1 in medaka. Angular VOR appeared much later than OKR, initially at only high accelerations (>200°/s at 0.5 Hz), first in medaka followed by larger (8.11 mm) zebrafish; but it was virtually nonexistent in goldfish. Velocity storage was not observed except for an eye velocity build-up in the largest medaka. In summary, a robust OKR was achieved shortly after hatching in all three species. In contrast, larval fish seem to be unique among vertebrates tested in their lack of significant angular VOR at stages where active movement is required for feeding and survival.
Address for reprint requests and other correspondence: J. C. Beck, Dept. of Physiology and Neuroscience, MSB-442, NYU School of Medicine, 550 First Ave, New York, NY 10016 (E-mail: james.beck{at}med.nyu.edu ).</description><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Carassius auratus</subject><subject>Danio rerio</subject><subject>Fishes - physiology</subject><subject>Freshwater</subject><subject>Goldfish</subject><subject>Nystagmus, Physiologic - physiology</subject><subject>Oryzias</subject><subject>Oryzias latipes</subject><subject>Reflex, Vestibulo-Ocular - physiology</subject><subject>Saccades - physiology</subject><subject>Vision, Monocular - physiology</subject><subject>Zebrafish</subject><issn>0022-3077</issn><issn>1522-1598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS1ERZfCkSvyCS7NMnYSZ3OEihakViukwoGL5STjjbdeO7UTIP8eb3dVTqinGc1872k0j5A3DJaMlfzD1i0BcsaWHKB4RhZpxjNW1qvnZAGQ-hyq6pS8jHELAFUJ_AU5TZCoec4WpP82KTcaPRu3oWOPdO1Gv0E3U6_pehj9nXE4mpYq19EfGEfTTNb7drIq0E_Yq1_Gh0iNoz-xCUqb2J_TG-zUnTp_0Fx52-2nr8iJVjbi62M9I98vP99efMmu11dfLz5eZ20h-Ji1vEaWOq1bLXjyUVqscuStgKpLC9Y2AkteQ97VQhWsBGwKbBQDDRo15Gfk3cF3CP5-SgfLnYktWqsc-ilKUUG1KorqSZDVBVRsxRKYHcA2-BgDajkEs1NhlgzkPgO5dfIhA7nPIPFvj8ZTs8PuH318egLeH4DebPrfJqAc-jkab_1m3nvVXAqZl4VIZP5_8nKy9hb_jEnyqJBDp_O_pB2jVQ</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Beck, James C</creator><creator>Gilland, Edwin</creator><creator>Tank, David W</creator><creator>Baker, Robert</creator><general>Am Phys Soc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>Quantifying the Ontogeny of Optokinetic and Vestibuloocular Behaviors in Zebrafish, Medaka, and Goldfish</title><author>Beck, James C ; Gilland, Edwin ; Tank, David W ; Baker, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-c29e1462ffcf62edaaf683e2c607d1461cb6e52903d96a4150eb4eba10f0fef03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Behavior, Animal - physiology</topic><topic>Carassius auratus</topic><topic>Danio rerio</topic><topic>Fishes - physiology</topic><topic>Freshwater</topic><topic>Goldfish</topic><topic>Nystagmus, Physiologic - physiology</topic><topic>Oryzias</topic><topic>Oryzias latipes</topic><topic>Reflex, Vestibulo-Ocular - physiology</topic><topic>Saccades - physiology</topic><topic>Vision, Monocular - physiology</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beck, James C</creatorcontrib><creatorcontrib>Gilland, Edwin</creatorcontrib><creatorcontrib>Tank, David W</creatorcontrib><creatorcontrib>Baker, Robert</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beck, James C</au><au>Gilland, Edwin</au><au>Tank, David W</au><au>Baker, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantifying the Ontogeny of Optokinetic and Vestibuloocular Behaviors in Zebrafish, Medaka, and Goldfish</atitle><jtitle>Journal of neurophysiology</jtitle><addtitle>J Neurophysiol</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>92</volume><issue>6</issue><spage>3546</spage><epage>3561</epage><pages>3546-3561</pages><issn>0022-3077</issn><eissn>1522-1598</eissn><abstract>1 Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016; and 2 Departments of Physics and Molecular Biology, Princeton University, Princeton, New Jersey 08544
Submitted 29 March 2004;
accepted in final form 20 July 2004
We quantitatively studied the ontogeny of oculomotor behavior in larval fish as a foundation for studies linking oculomotor structure and function with genetics. Horizontal optokinetic and vestibuloocular reflexes (OKR and VOR, respectively) were measured in three different species (goldfish, zebrafish, and medaka) during the first month after hatching. For all sizes of medaka, and most zebrafish, Bode plots of OKR (0.0653.0 Hz, ±10°/s) revealed that eye velocity closely followed stimulus velocity (gain > 0.8) at low frequency but dropped sharply above 1 Hz (gain < 0.3 at 3 Hz). Goldfish showed increased gain proportional to size across frequencies. Linearity testing with steps and sinusoids showed excellent visual performance (gain > 0.8) in medaka almost from hatching; but zebrafish and goldfish exhibited progressive improvement, with only the largest equaling medaka performance. Monocular visual stimulation in zebrafish and goldfish produced gains of 0.5 versus <0.1 for the eye viewing a moving versus stationary stimulus pattern but 0.25 versus <0.1 in medaka. Angular VOR appeared much later than OKR, initially at only high accelerations (>200°/s at 0.5 Hz), first in medaka followed by larger (8.11 mm) zebrafish; but it was virtually nonexistent in goldfish. Velocity storage was not observed except for an eye velocity build-up in the largest medaka. In summary, a robust OKR was achieved shortly after hatching in all three species. In contrast, larval fish seem to be unique among vertebrates tested in their lack of significant angular VOR at stages where active movement is required for feeding and survival.
Address for reprint requests and other correspondence: J. C. Beck, Dept. of Physiology and Neuroscience, MSB-442, NYU School of Medicine, 550 First Ave, New York, NY 10016 (E-mail: james.beck{at}med.nyu.edu ).</abstract><cop>United States</cop><pub>Am Phys Soc</pub><pmid>15269231</pmid><doi>10.1152/jn.00311.2004</doi><tpages>16</tpages></addata></record> |
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| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Behavior, Animal - physiology Carassius auratus Danio rerio Fishes - physiology Freshwater Goldfish Nystagmus, Physiologic - physiology Oryzias Oryzias latipes Reflex, Vestibulo-Ocular - physiology Saccades - physiology Vision, Monocular - physiology Zebrafish |
| title | Quantifying the Ontogeny of Optokinetic and Vestibuloocular Behaviors in Zebrafish, Medaka, and Goldfish |
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