Equol-producing status affects exercise training-induced improvement in arterial compliance in postmenopausal women
Central arterial compliance decreases drastically after menopause. Regular intake of soy isoflavone and aerobic exercise increase arterial compliance. The equol is a metabolite of isoflavone daidzein by gut microbiome. We determined whether the equol-producing status affects aerobic exercise-induced...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2021-03, Vol.130 (3), p.827-835 |
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| creator | Hayashi, Koichiro Yamaguchi, Hidetaka Amaoka, Hiroshi Takahara, Terumasa Kunisa, Shiori Tamai, Nanae Maejima, Nagisa Watanabe, Nana Kobayashi, Yui Tanaka, Hirofumi |
| description | Central arterial compliance decreases drastically after menopause. Regular intake of soy isoflavone and aerobic exercise increase arterial compliance. The equol is a metabolite of isoflavone daidzein by gut microbiome. We determined whether the equol-producing status affects aerobic exercise-induced improvement in carotid arterial compliance. Forty-three postmenopausal women were assigned to two intervention groups:
) exercise and isoflavone (Ex+Iso,
= 27 females) or
) isoflavone interventions (Iso;
= 16 females). Participants of the Ex+Iso intervention group completed an 8-wk aerobic exercise training, and all participants were administered with oral isoflavone supplements during the interventions. The equol-producing status (equol producers or nonproducers) was determined from urine equol concentrations after a soy challenge. In the Ex+Iso intervention group, carotid arterial compliance increased in the equol producers (0.084 ± 0.030→0.117 ± 0.035 mm
/mmHg), but not in the nonproducers (0.089 ± 0.028→0.097 ± 0.026 mm
/mmHg) after the intervention (interaction effect;
< 0.05). The magnitude of increases in carotid arterial compliance was significantly greater in the equol producers than in the non-equol producers (
< 0.05). In the isoflavone intervention group, there were no changes in any parameters after the intervention irrespective of the equol status. These results suggest that equol-producing status is obligatory to aerobic exercise training-induced improvements in central arterial compliance in postmenopausal women.
Isoflavone intake and aerobic exercise increase central artery compliance. Equol, a metabolite of isoflavone daidzein by gut microbiome, has beneficial effects on vascular function. We demonstrated for the first time that the interaction of aerobic exercise and equol production status plays an essential role in improvements in central artery compliance in postmenopausal women. More specifically, the equol-producing status was obligatory to exercise training-induced improvements in central arterial compliance in postmenopausal women. |
| doi_str_mv | 10.1152/japplphysiol.00651.2020 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1152_japplphysiol_00651_2020</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2507170554</sourcerecordid><originalsourceid>FETCH-LOGICAL-c407t-73d1bfec22e384e4febac38f62c1d914338aad3ddb5bfcc006cbcdfcb54894823</originalsourceid><addsrcrecordid>eNpdkclOwzAURS0EgjL8AkRiwybFY50uESqDVIkNrC3HfgFXSZzaDsPf40JBiJVlv3OfrnwQOiN4Soiglys9DO3w8hGdb6cYzwSZUkzxDprkKS3JDJNdNKmkwKUUlTxAhzGuMCacC7KPDhhjYjav6ATFxXr0bTkEb0fj-uciJp3GWOimAZNiAe8QjItQpKBdn4HS9ZkEW7guh16hgz4Vri90SBCcbgvju6F1ujeweR58TBnxgx5jHr75fDlGe41uI5xszyP0dLN4vL4rlw-399dXy9JwLFMpmSV1bkEpsIoDb6DWhlXNjBpi54QzVmltmbW1qBtj8i-Y2tjG1IJXc15RdoQuvvfmousRYlKdiwbaVvfgx6gol4xjyqTI6Pk_dOXH0Od2igosicRC8EzJb8oEH2OARg3BdTp8KILVxov660V9eVEbLzl5ut0_1h3Y39yPCPYJ1CSRLw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2507170554</pqid></control><display><type>article</type><title>Equol-producing status affects exercise training-induced improvement in arterial compliance in postmenopausal women</title><source>American Physiological Society</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Hayashi, Koichiro ; Yamaguchi, Hidetaka ; Amaoka, Hiroshi ; Takahara, Terumasa ; Kunisa, Shiori ; Tamai, Nanae ; Maejima, Nagisa ; Watanabe, Nana ; Kobayashi, Yui ; Tanaka, Hirofumi</creator><creatorcontrib>Hayashi, Koichiro ; Yamaguchi, Hidetaka ; Amaoka, Hiroshi ; Takahara, Terumasa ; Kunisa, Shiori ; Tamai, Nanae ; Maejima, Nagisa ; Watanabe, Nana ; Kobayashi, Yui ; Tanaka, Hirofumi</creatorcontrib><description>Central arterial compliance decreases drastically after menopause. Regular intake of soy isoflavone and aerobic exercise increase arterial compliance. The equol is a metabolite of isoflavone daidzein by gut microbiome. We determined whether the equol-producing status affects aerobic exercise-induced improvement in carotid arterial compliance. Forty-three postmenopausal women were assigned to two intervention groups:
) exercise and isoflavone (Ex+Iso,
= 27 females) or
) isoflavone interventions (Iso;
= 16 females). Participants of the Ex+Iso intervention group completed an 8-wk aerobic exercise training, and all participants were administered with oral isoflavone supplements during the interventions. The equol-producing status (equol producers or nonproducers) was determined from urine equol concentrations after a soy challenge. In the Ex+Iso intervention group, carotid arterial compliance increased in the equol producers (0.084 ± 0.030→0.117 ± 0.035 mm
/mmHg), but not in the nonproducers (0.089 ± 0.028→0.097 ± 0.026 mm
/mmHg) after the intervention (interaction effect;
< 0.05). The magnitude of increases in carotid arterial compliance was significantly greater in the equol producers than in the non-equol producers (
< 0.05). In the isoflavone intervention group, there were no changes in any parameters after the intervention irrespective of the equol status. These results suggest that equol-producing status is obligatory to aerobic exercise training-induced improvements in central arterial compliance in postmenopausal women.
Isoflavone intake and aerobic exercise increase central artery compliance. Equol, a metabolite of isoflavone daidzein by gut microbiome, has beneficial effects on vascular function. We demonstrated for the first time that the interaction of aerobic exercise and equol production status plays an essential role in improvements in central artery compliance in postmenopausal women. More specifically, the equol-producing status was obligatory to exercise training-induced improvements in central arterial compliance in postmenopausal women.</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.00651.2020</identifier><identifier>PMID: 33356982</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Aerobics ; Compliance ; Daidzein ; Exercise ; Fitness training programs ; Intervention ; Intestinal microflora ; Isoflavones ; Menopause ; Metabolites ; Microbiomes ; Physical fitness ; Physical training ; Post-menopause ; Training</subject><ispartof>Journal of applied physiology (1985), 2021-03, Vol.130 (3), p.827-835</ispartof><rights>Copyright American Physiological Society Mar 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-73d1bfec22e384e4febac38f62c1d914338aad3ddb5bfcc006cbcdfcb54894823</citedby><cites>FETCH-LOGICAL-c407t-73d1bfec22e384e4febac38f62c1d914338aad3ddb5bfcc006cbcdfcb54894823</cites><orcidid>0000-0003-4399-7245</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33356982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hayashi, Koichiro</creatorcontrib><creatorcontrib>Yamaguchi, Hidetaka</creatorcontrib><creatorcontrib>Amaoka, Hiroshi</creatorcontrib><creatorcontrib>Takahara, Terumasa</creatorcontrib><creatorcontrib>Kunisa, Shiori</creatorcontrib><creatorcontrib>Tamai, Nanae</creatorcontrib><creatorcontrib>Maejima, Nagisa</creatorcontrib><creatorcontrib>Watanabe, Nana</creatorcontrib><creatorcontrib>Kobayashi, Yui</creatorcontrib><creatorcontrib>Tanaka, Hirofumi</creatorcontrib><title>Equol-producing status affects exercise training-induced improvement in arterial compliance in postmenopausal women</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Central arterial compliance decreases drastically after menopause. Regular intake of soy isoflavone and aerobic exercise increase arterial compliance. The equol is a metabolite of isoflavone daidzein by gut microbiome. We determined whether the equol-producing status affects aerobic exercise-induced improvement in carotid arterial compliance. Forty-three postmenopausal women were assigned to two intervention groups:
) exercise and isoflavone (Ex+Iso,
= 27 females) or
) isoflavone interventions (Iso;
= 16 females). Participants of the Ex+Iso intervention group completed an 8-wk aerobic exercise training, and all participants were administered with oral isoflavone supplements during the interventions. The equol-producing status (equol producers or nonproducers) was determined from urine equol concentrations after a soy challenge. In the Ex+Iso intervention group, carotid arterial compliance increased in the equol producers (0.084 ± 0.030→0.117 ± 0.035 mm
/mmHg), but not in the nonproducers (0.089 ± 0.028→0.097 ± 0.026 mm
/mmHg) after the intervention (interaction effect;
< 0.05). The magnitude of increases in carotid arterial compliance was significantly greater in the equol producers than in the non-equol producers (
< 0.05). In the isoflavone intervention group, there were no changes in any parameters after the intervention irrespective of the equol status. These results suggest that equol-producing status is obligatory to aerobic exercise training-induced improvements in central arterial compliance in postmenopausal women.
Isoflavone intake and aerobic exercise increase central artery compliance. Equol, a metabolite of isoflavone daidzein by gut microbiome, has beneficial effects on vascular function. We demonstrated for the first time that the interaction of aerobic exercise and equol production status plays an essential role in improvements in central artery compliance in postmenopausal women. More specifically, the equol-producing status was obligatory to exercise training-induced improvements in central arterial compliance in postmenopausal women.</description><subject>Aerobics</subject><subject>Compliance</subject><subject>Daidzein</subject><subject>Exercise</subject><subject>Fitness training programs</subject><subject>Intervention</subject><subject>Intestinal microflora</subject><subject>Isoflavones</subject><subject>Menopause</subject><subject>Metabolites</subject><subject>Microbiomes</subject><subject>Physical fitness</subject><subject>Physical training</subject><subject>Post-menopause</subject><subject>Training</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkclOwzAURS0EgjL8AkRiwybFY50uESqDVIkNrC3HfgFXSZzaDsPf40JBiJVlv3OfrnwQOiN4Soiglys9DO3w8hGdb6cYzwSZUkzxDprkKS3JDJNdNKmkwKUUlTxAhzGuMCacC7KPDhhjYjav6ATFxXr0bTkEb0fj-uciJp3GWOimAZNiAe8QjItQpKBdn4HS9ZkEW7guh16hgz4Vri90SBCcbgvju6F1ujeweR58TBnxgx5jHr75fDlGe41uI5xszyP0dLN4vL4rlw-399dXy9JwLFMpmSV1bkEpsIoDb6DWhlXNjBpi54QzVmltmbW1qBtj8i-Y2tjG1IJXc15RdoQuvvfmousRYlKdiwbaVvfgx6gol4xjyqTI6Pk_dOXH0Od2igosicRC8EzJb8oEH2OARg3BdTp8KILVxov660V9eVEbLzl5ut0_1h3Y39yPCPYJ1CSRLw</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Hayashi, Koichiro</creator><creator>Yamaguchi, Hidetaka</creator><creator>Amaoka, Hiroshi</creator><creator>Takahara, Terumasa</creator><creator>Kunisa, Shiori</creator><creator>Tamai, Nanae</creator><creator>Maejima, Nagisa</creator><creator>Watanabe, Nana</creator><creator>Kobayashi, Yui</creator><creator>Tanaka, Hirofumi</creator><general>American Physiological Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4399-7245</orcidid></search><sort><creationdate>20210301</creationdate><title>Equol-producing status affects exercise training-induced improvement in arterial compliance in postmenopausal women</title><author>Hayashi, Koichiro ; Yamaguchi, Hidetaka ; Amaoka, Hiroshi ; Takahara, Terumasa ; Kunisa, Shiori ; Tamai, Nanae ; Maejima, Nagisa ; Watanabe, Nana ; Kobayashi, Yui ; Tanaka, Hirofumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-73d1bfec22e384e4febac38f62c1d914338aad3ddb5bfcc006cbcdfcb54894823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aerobics</topic><topic>Compliance</topic><topic>Daidzein</topic><topic>Exercise</topic><topic>Fitness training programs</topic><topic>Intervention</topic><topic>Intestinal microflora</topic><topic>Isoflavones</topic><topic>Menopause</topic><topic>Metabolites</topic><topic>Microbiomes</topic><topic>Physical fitness</topic><topic>Physical training</topic><topic>Post-menopause</topic><topic>Training</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hayashi, Koichiro</creatorcontrib><creatorcontrib>Yamaguchi, Hidetaka</creatorcontrib><creatorcontrib>Amaoka, Hiroshi</creatorcontrib><creatorcontrib>Takahara, Terumasa</creatorcontrib><creatorcontrib>Kunisa, Shiori</creatorcontrib><creatorcontrib>Tamai, Nanae</creatorcontrib><creatorcontrib>Maejima, Nagisa</creatorcontrib><creatorcontrib>Watanabe, Nana</creatorcontrib><creatorcontrib>Kobayashi, Yui</creatorcontrib><creatorcontrib>Tanaka, Hirofumi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hayashi, Koichiro</au><au>Yamaguchi, Hidetaka</au><au>Amaoka, Hiroshi</au><au>Takahara, Terumasa</au><au>Kunisa, Shiori</au><au>Tamai, Nanae</au><au>Maejima, Nagisa</au><au>Watanabe, Nana</au><au>Kobayashi, Yui</au><au>Tanaka, Hirofumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Equol-producing status affects exercise training-induced improvement in arterial compliance in postmenopausal women</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>130</volume><issue>3</issue><spage>827</spage><epage>835</epage><pages>827-835</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><abstract>Central arterial compliance decreases drastically after menopause. Regular intake of soy isoflavone and aerobic exercise increase arterial compliance. The equol is a metabolite of isoflavone daidzein by gut microbiome. We determined whether the equol-producing status affects aerobic exercise-induced improvement in carotid arterial compliance. Forty-three postmenopausal women were assigned to two intervention groups:
) exercise and isoflavone (Ex+Iso,
= 27 females) or
) isoflavone interventions (Iso;
= 16 females). Participants of the Ex+Iso intervention group completed an 8-wk aerobic exercise training, and all participants were administered with oral isoflavone supplements during the interventions. The equol-producing status (equol producers or nonproducers) was determined from urine equol concentrations after a soy challenge. In the Ex+Iso intervention group, carotid arterial compliance increased in the equol producers (0.084 ± 0.030→0.117 ± 0.035 mm
/mmHg), but not in the nonproducers (0.089 ± 0.028→0.097 ± 0.026 mm
/mmHg) after the intervention (interaction effect;
< 0.05). The magnitude of increases in carotid arterial compliance was significantly greater in the equol producers than in the non-equol producers (
< 0.05). In the isoflavone intervention group, there were no changes in any parameters after the intervention irrespective of the equol status. These results suggest that equol-producing status is obligatory to aerobic exercise training-induced improvements in central arterial compliance in postmenopausal women.
Isoflavone intake and aerobic exercise increase central artery compliance. Equol, a metabolite of isoflavone daidzein by gut microbiome, has beneficial effects on vascular function. We demonstrated for the first time that the interaction of aerobic exercise and equol production status plays an essential role in improvements in central artery compliance in postmenopausal women. More specifically, the equol-producing status was obligatory to exercise training-induced improvements in central arterial compliance in postmenopausal women.</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>33356982</pmid><doi>10.1152/japplphysiol.00651.2020</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4399-7245</orcidid></addata></record> |
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| ispartof | Journal of applied physiology (1985), 2021-03, Vol.130 (3), p.827-835 |
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| source | American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Aerobics Compliance Daidzein Exercise Fitness training programs Intervention Intestinal microflora Isoflavones Menopause Metabolites Microbiomes Physical fitness Physical training Post-menopause Training |
| title | Equol-producing status affects exercise training-induced improvement in arterial compliance in postmenopausal women |
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