Alveolar sphingolipids generated in response to TNF-alpha modifies surfactant biophysical activity

Departments of 1 Internal Medicine and 2 Biochemistry, and the Department of Veterans Affairs Medical Center, The University of Iowa College of Medicine, Iowa City, Iowa 52242 Sphingolipids represent a diverse group of bioactive lipid species that are generated intracellularly in response to tumor...

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Veröffentlicht in:	Journal of applied physiology (1985) 2003-01, Vol.94 (1), p.253-258
Hauptverfasser:	Ryan, Alan J, McCoy, Diann M, McGowan, Stephen E, Salome, Ronald G, Mallampalli, Rama K
Format:	Artikel
Sprache:	eng
Schlagworte:	Air breathing Anatomy & physiology Animals Biological and medical sciences Biophysical Phenomena Biophysics Capillary Permeability - drug effects Ceramides - pharmacology Coloring Agents - pharmacokinetics Evans Blue - pharmacokinetics Fundamental and applied biological sciences. Psychology Lipids Lungs Male Pulmonary Alveoli - metabolism Pulmonary Circulation - drug effects Pulmonary Surfactants - metabolism Rats Rats, Sprague-Dawley Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Sphingolipids - physiology Sphingomyelin Phosphodiesterase - metabolism Surface Tension Tumor Necrosis Factor-alpha - pharmacology Tumors Vertebrates: respiratory system
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