Characterization of the transport activity of SGLT2/MAP17, the renal low-affinity Na + -glucose cotransporter

The cotransporter SGLT2 is responsible for 90% of renal glucose reabsorption, and we recently showed that MAP17 appears to work as a required β-subunit. We report in the present study a detailed functional characterization of human SGLT2 in coexpression with human MAP17 in oocytes. Addition of exter...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Renal physiology 2017-08, Vol.313 (2), p.F467-F474
Hauptverfasser:	Coady, Michael J, Wallendorff, Bernadette, Lapointe, Jean-Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	3-O-Methylglucose - metabolism Animals Benzhydryl Compounds - pharmacology Biological Transport Dose-Response Relationship, Drug Galactose Glucose - metabolism Glucosides - pharmacology Humans Kidney - drug effects Kidney - metabolism Kinetics Membrane Potentials Membrane Proteins - genetics Membrane Proteins - metabolism Methylglucosides - metabolism Phlorhizin - pharmacology Renal Reabsorption - drug effects Sodium - metabolism Sodium-Glucose Transporter 2 - genetics Sodium-Glucose Transporter 2 - metabolism Sodium-Glucose Transporter 2 Inhibitors Xenopus laevis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!