Chronic renal injury-induced hypertension alters renal NHE3 distribution and abundance

Renal cortical phenol injection provokes acute sympathetic nervous system-dependent hypertension and a shift of proximal tubule Na(+)/H(+) exchanger isoform 3 (NHE3) and Na(+)-P(i) cotransporter type 2 (NaPi2) to apical microvilli. This study aimed to determine whether proximal tubule (PT) Na(+) tra...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2003-05, Vol.284 (5), p.F1056-F1065
Hauptverfasser:	Yang, Li E, Zhong, Huiqin, Leong, Patrick K K, Perianayagam, Anjana, Campese, Vito M, McDonough, Alicia A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - drug effects Chronic Disease Hypertension - etiology Hypertension - metabolism Immunoblotting Immunohistochemistry Injections Intracellular Membranes - enzymology Kidney - drug effects Kidney - metabolism Kidney Cortex - metabolism Kidney Diseases - chemically induced Kidney Diseases - complications Kidney Medulla - metabolism Male Membrane Proteins - metabolism Phenol - pharmacology Rats Rats, Sprague-Dawley Sodium-Hydrogen Exchanger 3 Sodium-Hydrogen Exchangers - metabolism Sodium-Phosphate Cotransporter Proteins Sodium-Phosphate Cotransporter Proteins, Type II Sodium-Potassium-Exchanging ATPase - metabolism Symporters - metabolism Systole Tissue Distribution
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