Altered expression of selected genes in kidney of rats with lithium-induced NDI

Lithium treatment is associated with development of nephrogenic diabetes insipidus, caused in part by downregulation of collecting duct aquaporin-2 (AQP2) and AQP3 expression. In the present study, we carried out cDNA microarray screening of gene expression in the inner medulla (IM) of lithium-treat...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2005-06, Vol.288 (6), p.F1276-F1289
Hauptverfasser:	Rojek, Aleksandra, Nielsen, Jakob, Brooks, Heddwen L, Gong, Hong, Kim, Young-Hee, Kwon, Tae-Hwan, Frøkiaer, Jørgen, Nielsen, Søren
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenase Type 2 - genetics Adjuvants, Immunologic - toxicity Aldehyde Reductase - genetics Animals Cell Cycle Proteins - genetics Cyclin-Dependent Kinase Inhibitor p27 Cytoskeletal Proteins Diabetes Insipidus, Nephrogenic - chemically induced Diabetes Insipidus, Nephrogenic - genetics Diabetes Insipidus, Nephrogenic - physiopathology Gene Expression - drug effects Heat-Shock Proteins - genetics HSP27 Heat-Shock Proteins Kidney - drug effects Kidney - physiology Lithium Chloride - toxicity Male Neoplasm Proteins - genetics Oligonucleotide Array Sequence Analysis Osmolar Concentration Phosphoproteins - genetics Rats Rats, Inbred WKY Rats, Wistar RNA, Messenger - analysis Tumor Suppressor Proteins - genetics
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