Luminal ANG II is internalized as a complex with AT 1 R/AT 2 R heterodimers to target endoplasmic reticulum in LLC-PK 1 cells

ANG II has many biological effects in renal physiology, particularly in Ca handling in the regulation of fluid and solute reabsorption. It involves the systemic endocrine renin-angiotensin system (RAS), but tissue and intracrine ANG II are also known. We have shown that ANG II induces heterodimeriza...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2017-08, Vol.313 (2), p.F440-F449
Hauptverfasser:	Ferrão, Fernanda M, Cardoso, Luiza H D, Drummond, Heather A, Li, Xiao C, Zhuo, Jia L, Gomes, Dayene S, Lara, Lucienne S, Vieyra, Adalberto, Lowe, Jennifer
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - metabolism Angiotensin II Type 1 Receptor Blockers - pharmacology Angiotensin II Type 2 Receptor Blockers - pharmacology Animals beta-Arrestins - metabolism Calcium - metabolism Cell Membrane - drug effects Cell Membrane - metabolism Endocytosis - drug effects Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Kidney - drug effects Kidney - metabolism LLC-PK1 Cells Microtubules - metabolism Multiprotein Complexes Phosphorylation Protein Kinase C-alpha - metabolism Protein Transport Receptor, Angiotensin, Type 1 - drug effects Receptor, Angiotensin, Type 1 - metabolism Receptor, Angiotensin, Type 2 - drug effects Receptor, Angiotensin, Type 2 - metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism Swine
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