ADF/cofilin mediates actin cytoskeletal alterations in LLC-PK cells during ATP depletion

Ischemic injury induces actin cytoskeleton disruption and aggregation, but mechanisms affecting these changes remain unclear. To determine the role of actin-depolymerizing factor (ADF)/ cofilin participation in ischemic-induced actin cytoskeletal breakdown, we utilized porcine kidney cultured cells,...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2003-04, Vol.284 (4), p.F852-F862
Hauptverfasser:	Ashworth, Sharon L, Southgate, Erica L, Sandoval, Ruben M, Meberg, Peter J, Bamburg, James R, Molitoris, Bruce A
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Depolymerizing Factors Actins - metabolism Adenosine Triphosphate - metabolism Adenoviridae - genetics Animals Antimycin A - pharmacology Cell Line Cell Membrane - metabolism Cytoskeleton - drug effects Cytoskeleton - metabolism Destrin Gene Transfer Techniques Green Fluorescent Proteins Kidney - cytology Kidney - drug effects Kidney - metabolism LLC-PK1 Cells Luminescent Proteins - genetics Mice Microfilament Proteins - genetics Microfilament Proteins - metabolism Microscopy, Fluorescence Mutagenesis, Site-Directed Protein Isoforms - genetics Protein Isoforms - metabolism Protein Transport - drug effects Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Swine Xenopus
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