Proinsulin C-peptide constricts glomerular afferent arterioles in diabetic mice. A potential renoprotective mechanism

1 Department of Medical Cell Biology, Division of Physiology, University of Uppsala, Uppsala, Sweden; and 2 Johannes-Müller-Institute of Physiology, University Hospital Charité Humboldt-University of Berlin, Berlin, Germany Submitted 7 November 2007 ; accepted in final form 4 December 2007 Objective...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2008-03, Vol.294 (3), p.R836-R841
Hauptverfasser:	Nordquist, Lina, Lai, En Yin, Sjoquist, Mats, Patzak, Andreas, Persson, A. Erik G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Angiotensin II - pharmacology Animals Arterioles - anatomy & histology Arterioles - drug effects Biologi Biology C-Peptide - pharmacology diabetes Diabetes Mellitus, Experimental - pathology Diabetic Nephropathies - pathology Diabetic neuropathy Effects Enzyme Inhibitors - pharmacology glomerular filtration rate Kidney Glomerulus - blood supply Kidney Glomerulus - drug effects Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinases - physiology NATURAL SCIENCES NATURVETENSKAP Norepinephrine - pharmacology Peptides Potassium Chloride - pharmacology Pyridines - pharmacology renal function Rho Factor - metabolism rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism Rodents Studies Vasoconstriction - drug effects Vasoconstrictor Agents - pharmacology
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