A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring
1 Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, King's College, London; and 2 Centre for the Developmental Origins of Health and Disease, Princess Anne Hospital, Southampton, United Kingdom Submitted 1 June 2004 ; accepted in final form 31 Jul...
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| Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2005-01, Vol.288 (1), p.R127-R133 |
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| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
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| creator | Khan, I. Y Dekou, V Douglas, G Jensen, R Hanson, M. A Poston, L Taylor, P. D |
| description | 1 Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, King's College, London; and 2 Centre for the Developmental Origins of Health and Disease, Princess Anne Hospital, Southampton, United Kingdom
Submitted 1 June 2004
; accepted in final form 31 July 2004
Epidemiological and animal studies suggest that diet-induced epigenetic modifications in early life can contribute to development of the metabolic syndrome in adulthood. We previously reported features of the metabolic syndrome in adult offspring of rats fed a diet rich in animal fat during pregnancy and suckling. We now report a study to compare the relative effects of high-fat feeding during 1 ) pregnancy and 2 ) the suckling period in the development of these disorders. As observed previously, 6-mo-old female offspring of fat-fed dams suckled by the same fat-fed dams (OHF) demonstrated raised blood pressure, despite being fed a balanced diet from weaning. Female offspring of fat-fed dams "cross fostered" to dams consuming a control diet during suckling (OHF/C) demonstrated raised blood pressure compared with controls (OC) [systolic blood pressure (SBP; mmHg) means ± SE: OHF/C, 132.5 ± 3.0, n = 6 vs. OC, 119.0 ± 3.8, n = 7, P < 0.05]. Female offspring of controls cross fostered to dams consuming the fat diet (OC/HF) were also hypertensive [SBP (mmHg) 131.0 ± 2.5 mmHg, n = 6 vs. OC, P < 0.05]. Endothelium-dependent relaxation (EDR) of male and female OHF and OHF/C mesenteric small arteries was similar and blunted compared with OC ( P < 0.001). OC/HF arteries showed profoundly impaired EDR (OC/HF vs. OHF, P < 0.001). OHF/C and OC/HF demonstrated hyperinsulinemia and increased adiposity. Features of the metabolic syndrome in adult offspring of fat-fed rats can be acquired both antenatally and during suckling. However, exposure during pregnancy confers adaptive protection against endothelial dysfunction induced by maternal fat feeding during suckling.
blood pressure; endothelium; developmental programming
Address for reprint requests and other correspondence: P. D. Taylor, Division of Reproductive Health, Endocrinology and Development, St. Thomas' Hospital, London SE1 7EH, UK (E-mail: paul.taylor{at}kcl.ac.uk ) |
| doi_str_mv | 10.1152/ajpregu.00354.2004 |
| format | Article |
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Submitted 1 June 2004
; accepted in final form 31 July 2004
Epidemiological and animal studies suggest that diet-induced epigenetic modifications in early life can contribute to development of the metabolic syndrome in adulthood. We previously reported features of the metabolic syndrome in adult offspring of rats fed a diet rich in animal fat during pregnancy and suckling. We now report a study to compare the relative effects of high-fat feeding during 1 ) pregnancy and 2 ) the suckling period in the development of these disorders. As observed previously, 6-mo-old female offspring of fat-fed dams suckled by the same fat-fed dams (OHF) demonstrated raised blood pressure, despite being fed a balanced diet from weaning. Female offspring of fat-fed dams "cross fostered" to dams consuming a control diet during suckling (OHF/C) demonstrated raised blood pressure compared with controls (OC) [systolic blood pressure (SBP; mmHg) means ± SE: OHF/C, 132.5 ± 3.0, n = 6 vs. OC, 119.0 ± 3.8, n = 7, P < 0.05]. Female offspring of controls cross fostered to dams consuming the fat diet (OC/HF) were also hypertensive [SBP (mmHg) 131.0 ± 2.5 mmHg, n = 6 vs. OC, P < 0.05]. Endothelium-dependent relaxation (EDR) of male and female OHF and OHF/C mesenteric small arteries was similar and blunted compared with OC ( P < 0.001). OC/HF arteries showed profoundly impaired EDR (OC/HF vs. OHF, P < 0.001). OHF/C and OC/HF demonstrated hyperinsulinemia and increased adiposity. Features of the metabolic syndrome in adult offspring of fat-fed rats can be acquired both antenatally and during suckling. However, exposure during pregnancy confers adaptive protection against endothelial dysfunction induced by maternal fat feeding during suckling.
blood pressure; endothelium; developmental programming
Address for reprint requests and other correspondence: P. D. Taylor, Division of Reproductive Health, Endocrinology and Development, St. Thomas' Hospital, London SE1 7EH, UK (E-mail: paul.taylor{at}kcl.ac.uk )</description><identifier>ISSN: 0363-6119</identifier><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.00354.2004</identifier><identifier>PMID: 15308487</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Body Weight ; Dietary Fats - pharmacology ; Feeding Behavior - physiology ; Female ; Heart Rate - drug effects ; Hemodynamics - drug effects ; Hemodynamics - physiology ; Lactation ; Maternal Nutritional Physiological Phenomena - physiology ; Mesenteric Arteries - physiopathology ; Metabolic Syndrome - embryology ; Pregnancy ; Prenatal Exposure Delayed Effects ; Prenatal Nutritional Physiological Phenomena - physiology ; Rats ; Rats, Sprague-Dawley ; Vasodilation - drug effects</subject><ispartof>American journal of physiology. Regulatory, integrative and comparative physiology, 2005-01, Vol.288 (1), p.R127-R133</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-ba66c4fff6bd17d5e77ee4c6a9e269fcbac3fc3ecb046cc6f55d60fa18aeab403</citedby><cites>FETCH-LOGICAL-c455t-ba66c4fff6bd17d5e77ee4c6a9e269fcbac3fc3ecb046cc6f55d60fa18aeab403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15308487$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khan, I. Y</creatorcontrib><creatorcontrib>Dekou, V</creatorcontrib><creatorcontrib>Douglas, G</creatorcontrib><creatorcontrib>Jensen, R</creatorcontrib><creatorcontrib>Hanson, M. A</creatorcontrib><creatorcontrib>Poston, L</creatorcontrib><creatorcontrib>Taylor, P. D</creatorcontrib><title>A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring</title><title>American journal of physiology. Regulatory, integrative and comparative physiology</title><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><description>1 Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, King's College, London; and 2 Centre for the Developmental Origins of Health and Disease, Princess Anne Hospital, Southampton, United Kingdom
Submitted 1 June 2004
; accepted in final form 31 July 2004
Epidemiological and animal studies suggest that diet-induced epigenetic modifications in early life can contribute to development of the metabolic syndrome in adulthood. We previously reported features of the metabolic syndrome in adult offspring of rats fed a diet rich in animal fat during pregnancy and suckling. We now report a study to compare the relative effects of high-fat feeding during 1 ) pregnancy and 2 ) the suckling period in the development of these disorders. As observed previously, 6-mo-old female offspring of fat-fed dams suckled by the same fat-fed dams (OHF) demonstrated raised blood pressure, despite being fed a balanced diet from weaning. Female offspring of fat-fed dams "cross fostered" to dams consuming a control diet during suckling (OHF/C) demonstrated raised blood pressure compared with controls (OC) [systolic blood pressure (SBP; mmHg) means ± SE: OHF/C, 132.5 ± 3.0, n = 6 vs. OC, 119.0 ± 3.8, n = 7, P < 0.05]. Female offspring of controls cross fostered to dams consuming the fat diet (OC/HF) were also hypertensive [SBP (mmHg) 131.0 ± 2.5 mmHg, n = 6 vs. OC, P < 0.05]. Endothelium-dependent relaxation (EDR) of male and female OHF and OHF/C mesenteric small arteries was similar and blunted compared with OC ( P < 0.001). OC/HF arteries showed profoundly impaired EDR (OC/HF vs. OHF, P < 0.001). OHF/C and OC/HF demonstrated hyperinsulinemia and increased adiposity. Features of the metabolic syndrome in adult offspring of fat-fed rats can be acquired both antenatally and during suckling. However, exposure during pregnancy confers adaptive protection against endothelial dysfunction induced by maternal fat feeding during suckling.
blood pressure; endothelium; developmental programming
Address for reprint requests and other correspondence: P. D. Taylor, Division of Reproductive Health, Endocrinology and Development, St. Thomas' Hospital, London SE1 7EH, UK (E-mail: paul.taylor{at}kcl.ac.uk )</description><subject>Animals</subject><subject>Body Weight</subject><subject>Dietary Fats - pharmacology</subject><subject>Feeding Behavior - physiology</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Hemodynamics - drug effects</subject><subject>Hemodynamics - physiology</subject><subject>Lactation</subject><subject>Maternal Nutritional Physiological Phenomena - physiology</subject><subject>Mesenteric Arteries - physiopathology</subject><subject>Metabolic Syndrome - embryology</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Prenatal Nutritional Physiological Phenomena - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Vasodilation - drug effects</subject><issn>0363-6119</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFu1DAURS1ERYfCD7BAXrHLYMeOkyyrirZIlZCqsracZ3vGxRMHOwby93U6A12xedbTO_fKOgh9oGRLaVN_Vo9TNLu8JYQ1fFsTwl-hTTnUFeU9eY02hAlWCUr7c_Q2pUdSCMbZG3ROG0Y63rUbZC_x3u32lVUz1s6UkaMbdziWfW0f1QgLDhGnDD_8enGjzmASBhW1C79UguxVxHpJNo8wuzAWBCud_YyDtWla-96hM6t8Mu9P7wX6fv3l4eq2uvt28_Xq8q4C3jRzNSghgFtrxaBpqxvTtsZwEKo3tegtDAqYBWZgIFwACNs0WhCraKeMGjhhF-jTsXeK4Wc2aZYHl8B4r0YTcpKiZVzQmhawPoIQQ0rRWFn-eVBxkZTI1a482ZXPduVqt4Q-ntrzcDD6JXLSWYDqCKxOf7to5LRfkgs-7JZ_hXXXSSrvab3y_f_56-z9g_kz_w2-5OSkLXsCTk6giQ</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Khan, I. Y</creator><creator>Dekou, V</creator><creator>Douglas, G</creator><creator>Jensen, R</creator><creator>Hanson, M. A</creator><creator>Poston, L</creator><creator>Taylor, P. D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050101</creationdate><title>A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring</title><author>Khan, I. Y ; Dekou, V ; Douglas, G ; Jensen, R ; Hanson, M. A ; Poston, L ; Taylor, P. 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Y</creatorcontrib><creatorcontrib>Dekou, V</creatorcontrib><creatorcontrib>Douglas, G</creatorcontrib><creatorcontrib>Jensen, R</creatorcontrib><creatorcontrib>Hanson, M. A</creatorcontrib><creatorcontrib>Poston, L</creatorcontrib><creatorcontrib>Taylor, P. D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, I. Y</au><au>Dekou, V</au><au>Douglas, G</au><au>Jensen, R</au><au>Hanson, M. A</au><au>Poston, L</au><au>Taylor, P. D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring</atitle><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>288</volume><issue>1</issue><spage>R127</spage><epage>R133</epage><pages>R127-R133</pages><issn>0363-6119</issn><eissn>1522-1490</eissn><abstract>1 Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development, King's College, London; and 2 Centre for the Developmental Origins of Health and Disease, Princess Anne Hospital, Southampton, United Kingdom
Submitted 1 June 2004
; accepted in final form 31 July 2004
Epidemiological and animal studies suggest that diet-induced epigenetic modifications in early life can contribute to development of the metabolic syndrome in adulthood. We previously reported features of the metabolic syndrome in adult offspring of rats fed a diet rich in animal fat during pregnancy and suckling. We now report a study to compare the relative effects of high-fat feeding during 1 ) pregnancy and 2 ) the suckling period in the development of these disorders. As observed previously, 6-mo-old female offspring of fat-fed dams suckled by the same fat-fed dams (OHF) demonstrated raised blood pressure, despite being fed a balanced diet from weaning. Female offspring of fat-fed dams "cross fostered" to dams consuming a control diet during suckling (OHF/C) demonstrated raised blood pressure compared with controls (OC) [systolic blood pressure (SBP; mmHg) means ± SE: OHF/C, 132.5 ± 3.0, n = 6 vs. OC, 119.0 ± 3.8, n = 7, P < 0.05]. Female offspring of controls cross fostered to dams consuming the fat diet (OC/HF) were also hypertensive [SBP (mmHg) 131.0 ± 2.5 mmHg, n = 6 vs. OC, P < 0.05]. Endothelium-dependent relaxation (EDR) of male and female OHF and OHF/C mesenteric small arteries was similar and blunted compared with OC ( P < 0.001). OC/HF arteries showed profoundly impaired EDR (OC/HF vs. OHF, P < 0.001). OHF/C and OC/HF demonstrated hyperinsulinemia and increased adiposity. Features of the metabolic syndrome in adult offspring of fat-fed rats can be acquired both antenatally and during suckling. However, exposure during pregnancy confers adaptive protection against endothelial dysfunction induced by maternal fat feeding during suckling.
blood pressure; endothelium; developmental programming
Address for reprint requests and other correspondence: P. D. Taylor, Division of Reproductive Health, Endocrinology and Development, St. Thomas' Hospital, London SE1 7EH, UK (E-mail: paul.taylor{at}kcl.ac.uk )</abstract><cop>United States</cop><pmid>15308487</pmid><doi>10.1152/ajpregu.00354.2004</doi></addata></record> |
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| ispartof | American journal of physiology. Regulatory, integrative and comparative physiology, 2005-01, Vol.288 (1), p.R127-R133 |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Body Weight Dietary Fats - pharmacology Feeding Behavior - physiology Female Heart Rate - drug effects Hemodynamics - drug effects Hemodynamics - physiology Lactation Maternal Nutritional Physiological Phenomena - physiology Mesenteric Arteries - physiopathology Metabolic Syndrome - embryology Pregnancy Prenatal Exposure Delayed Effects Prenatal Nutritional Physiological Phenomena - physiology Rats Rats, Sprague-Dawley Vasodilation - drug effects |
| title | A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring |
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