Wavelet analysis of instantaneous heart rate: a study of autonomic control during thrombolysis
1 The Abramson Center for Medical Physics, Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978; and 2 Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer 52620, Israel Myocardial infarction (MI) is known to elicit activation of the autonomic nervous system. Re...
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| Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2003-04, Vol.284 (4), p.1079-R1091 |
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| container_issue | 4 |
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| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
| container_volume | 284 |
| creator | Toledo, Eran Gurevitz, Osnat Hod, Hanoch Eldar, Michael Akselrod, Solange |
| description | 1 The Abramson Center for Medical Physics, Sackler
Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978; and
2 Neufeld Cardiac Research Institute, Sheba Medical
Center, Tel Hashomer 52620, Israel
Myocardial infarction (MI) is known to
elicit activation of the autonomic nervous system. Reperfusion, induced
by thrombolysis, is thus expected to bring about a shift in the balance
between the sympathetic and vagal systems, according to the infarct
location. In this study, we explored the correlation between
reperfusion and the spectral components of heart rate (HR) variability
(HRV), which are associated with autonomic cardiac control. We analyzed the HR of patients during thrombolysis: nine anterior wall MI (AW-MI)
and eight inferoposterior wall MI (IW-MI). Reperfusion was determined
from changes in ST levels and reported pain. Reocclusion was detected
in four patients. HRV was analyzed using a modified continuous wavelet
transform, which provided time-dependent versions of the typically used
low-frequency (LF) and high-frequency (HF) peaks and of their ratio,
LF/HF. Marked alterations in at least one of the HRV parameters was
found in all 18 reperfusion events. Patterns of HRV, compatible with a
shift toward relative sympathetic enhancement, were found in all of the
nine reperfusion events in IW-MI patients and in three AW-MI patients.
Patterns of HRV compatible with relative vagal enhancement were found
in six AW-MI patients ( P |
| doi_str_mv | 10.1152/ajpregu.00287.2002 |
| format | Article |
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Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978; and
2 Neufeld Cardiac Research Institute, Sheba Medical
Center, Tel Hashomer 52620, Israel
Myocardial infarction (MI) is known to
elicit activation of the autonomic nervous system. Reperfusion, induced
by thrombolysis, is thus expected to bring about a shift in the balance
between the sympathetic and vagal systems, according to the infarct
location. In this study, we explored the correlation between
reperfusion and the spectral components of heart rate (HR) variability
(HRV), which are associated with autonomic cardiac control. We analyzed the HR of patients during thrombolysis: nine anterior wall MI (AW-MI)
and eight inferoposterior wall MI (IW-MI). Reperfusion was determined
from changes in ST levels and reported pain. Reocclusion was detected
in four patients. HRV was analyzed using a modified continuous wavelet
transform, which provided time-dependent versions of the typically used
low-frequency (LF) and high-frequency (HF) peaks and of their ratio,
LF/HF. Marked alterations in at least one of the HRV parameters was
found in all 18 reperfusion events. Patterns of HRV, compatible with a
shift toward relative sympathetic enhancement, were found in all of the
nine reperfusion events in IW-MI patients and in three AW-MI patients.
Patterns of HRV compatible with relative vagal enhancement were found
in six AW-MI patients ( P < 0.001). Significant changes
in HRV parameters were also found after reocclusion. Time-dependent
spectral analysis of HRV using the wavelet transform was found to be
valuable for explaining the patterns of cardiac rate control during
reperfusion. In addition, examination of the entire record revealed
epochs of markedly diminished HRV in two patients, which we attribute to vagal saturation.
wavelet transform; myocardial infarction; spectral analysis; heart
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Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978; and
2 Neufeld Cardiac Research Institute, Sheba Medical
Center, Tel Hashomer 52620, Israel
Myocardial infarction (MI) is known to
elicit activation of the autonomic nervous system. Reperfusion, induced
by thrombolysis, is thus expected to bring about a shift in the balance
between the sympathetic and vagal systems, according to the infarct
location. In this study, we explored the correlation between
reperfusion and the spectral components of heart rate (HR) variability
(HRV), which are associated with autonomic cardiac control. We analyzed the HR of patients during thrombolysis: nine anterior wall MI (AW-MI)
and eight inferoposterior wall MI (IW-MI). Reperfusion was determined
from changes in ST levels and reported pain. Reocclusion was detected
in four patients. HRV was analyzed using a modified continuous wavelet
transform, which provided time-dependent versions of the typically used
low-frequency (LF) and high-frequency (HF) peaks and of their ratio,
LF/HF. Marked alterations in at least one of the HRV parameters was
found in all 18 reperfusion events. Patterns of HRV, compatible with a
shift toward relative sympathetic enhancement, were found in all of the
nine reperfusion events in IW-MI patients and in three AW-MI patients.
Patterns of HRV compatible with relative vagal enhancement were found
in six AW-MI patients ( P < 0.001). Significant changes
in HRV parameters were also found after reocclusion. Time-dependent
spectral analysis of HRV using the wavelet transform was found to be
valuable for explaining the patterns of cardiac rate control during
reperfusion. In addition, examination of the entire record revealed
epochs of markedly diminished HRV in two patients, which we attribute to vagal saturation.
wavelet transform; myocardial infarction; spectral analysis; heart
rate variability</description><subject>Adult</subject><subject>Aged</subject><subject>Female</subject><subject>Fibrinolytic Agents - therapeutic use</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Myocardial Reperfusion</subject><subject>Streptokinase - therapeutic use</subject><subject>Thrombolytic Therapy</subject><subject>Time Factors</subject><subject>Tissue Plasminogen Activator - therapeutic use</subject><issn>0363-6119</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLJDEURoM4aPv4Ay4kK3fVk2c93InYOiAIQw-zm5BKJV0lqUqZpNT-96YfopuBwF3kfB_3HgAuMJpjzMlP-Tx6vZrmCJGymJM0DsAsfZAMswodghmiOc1yjKtjcBLCM0KIUUaPwDEmjOe0ZDPw76981VZHKAdp16EL0BnYDSHKIT3tpgBbLX2EXkZ9DSUMcWrWG0hO0Q2u7xRUbojeWdhMvhtWMLbe9bXbtp2BH0baoM_38xT8Wdwtbx-yx6f7X7c3j5linMesKbhCqio5q-pamZxyg7Ws6sKUhLIcS66UNLXKG4K0LBhmvG5KhQxjRFdY0lNwtesdvXuZdIii74LS1u5uEAVFRcUITiDZgcq7ELw2YvRdL_1aYCQ2VsXeqthaFRurKXS5b5_qXjdfkb3GBFzvgLZbtW-d12Js0_nOutVaLCZrl_o9fjaTkgkmfuO0kRgbk8Lz_4c_t_kWoh9mHZ0T</recordid><startdate>20030401</startdate><enddate>20030401</enddate><creator>Toledo, Eran</creator><creator>Gurevitz, Osnat</creator><creator>Hod, Hanoch</creator><creator>Eldar, Michael</creator><creator>Akselrod, Solange</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030401</creationdate><title>Wavelet analysis of instantaneous heart rate: a study of autonomic control during thrombolysis</title><author>Toledo, Eran ; Gurevitz, Osnat ; Hod, Hanoch ; Eldar, Michael ; Akselrod, Solange</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-d75c0c98549bbcf635f1ea9b7f823461a5ccafbc6d20ea74145bd8c0f442e91a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Female</topic><topic>Fibrinolytic Agents - therapeutic use</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Myocardial Infarction - drug therapy</topic><topic>Myocardial Reperfusion</topic><topic>Streptokinase - therapeutic use</topic><topic>Thrombolytic Therapy</topic><topic>Time Factors</topic><topic>Tissue Plasminogen Activator - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Toledo, Eran</creatorcontrib><creatorcontrib>Gurevitz, Osnat</creatorcontrib><creatorcontrib>Hod, Hanoch</creatorcontrib><creatorcontrib>Eldar, Michael</creatorcontrib><creatorcontrib>Akselrod, Solange</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Toledo, Eran</au><au>Gurevitz, Osnat</au><au>Hod, Hanoch</au><au>Eldar, Michael</au><au>Akselrod, Solange</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Wavelet analysis of instantaneous heart rate: a study of autonomic control during thrombolysis</atitle><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><date>2003-04-01</date><risdate>2003</risdate><volume>284</volume><issue>4</issue><spage>1079</spage><epage>R1091</epage><pages>1079-R1091</pages><issn>0363-6119</issn><eissn>1522-1490</eissn><abstract>1 The Abramson Center for Medical Physics, Sackler
Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978; and
2 Neufeld Cardiac Research Institute, Sheba Medical
Center, Tel Hashomer 52620, Israel
Myocardial infarction (MI) is known to
elicit activation of the autonomic nervous system. Reperfusion, induced
by thrombolysis, is thus expected to bring about a shift in the balance
between the sympathetic and vagal systems, according to the infarct
location. In this study, we explored the correlation between
reperfusion and the spectral components of heart rate (HR) variability
(HRV), which are associated with autonomic cardiac control. We analyzed the HR of patients during thrombolysis: nine anterior wall MI (AW-MI)
and eight inferoposterior wall MI (IW-MI). Reperfusion was determined
from changes in ST levels and reported pain. Reocclusion was detected
in four patients. HRV was analyzed using a modified continuous wavelet
transform, which provided time-dependent versions of the typically used
low-frequency (LF) and high-frequency (HF) peaks and of their ratio,
LF/HF. Marked alterations in at least one of the HRV parameters was
found in all 18 reperfusion events. Patterns of HRV, compatible with a
shift toward relative sympathetic enhancement, were found in all of the
nine reperfusion events in IW-MI patients and in three AW-MI patients.
Patterns of HRV compatible with relative vagal enhancement were found
in six AW-MI patients ( P < 0.001). Significant changes
in HRV parameters were also found after reocclusion. Time-dependent
spectral analysis of HRV using the wavelet transform was found to be
valuable for explaining the patterns of cardiac rate control during
reperfusion. In addition, examination of the entire record revealed
epochs of markedly diminished HRV in two patients, which we attribute to vagal saturation.
wavelet transform; myocardial infarction; spectral analysis; heart
rate variability</abstract><cop>United States</cop><pmid>12456384</pmid><doi>10.1152/ajpregu.00287.2002</doi></addata></record> |
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| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Female Fibrinolytic Agents - therapeutic use Heart Rate - drug effects Humans Male Myocardial Infarction - drug therapy Myocardial Reperfusion Streptokinase - therapeutic use Thrombolytic Therapy Time Factors Tissue Plasminogen Activator - therapeutic use |
| title | Wavelet analysis of instantaneous heart rate: a study of autonomic control during thrombolysis |
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