Hormonal and metabolic rhythms associated with the daily scheduled nursing in rabbit pups
1 Laboratorio de Biología de la Reproducción, IIB, Universidad Veracruzana, Xalapa, Veracruz, México; 2 Department of Psychology, University of Delaware, Newark, Delaware; 3 Departamento de Anatomía, Facultad de Medicina, Universidad Nacional Autónoma de México, México DF, Mexico; and 4 Center for N...
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| Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2008-08, Vol.295 (2), p.R690-R695 |
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| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
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| creator | Morgado, Elvira Gordon, M. Kathleen del Carmen Minana-Solis, Maria Meza, Enrique Levine, Seymour Escobar, Carolina Caba, Mario |
| description | 1 Laboratorio de Biología de la Reproducción, IIB, Universidad Veracruzana, Xalapa, Veracruz, México; 2 Department of Psychology, University of Delaware, Newark, Delaware; 3 Departamento de Anatomía, Facultad de Medicina, Universidad Nacional Autónoma de México, México DF, Mexico; and 4 Center for Neurosciences, University of California, Davis, California
Submitted 3 March 2008
; accepted in final form 13 May 2008
Young rabbits are nursed every 24 h for a period of 3–5 min. As a consequence, pups are synchronized to this nursing event; this synchronization is characterized by increased locomotor activity and a peaking of core temperature and plasma corticosterone in anticipation of the daily meal. Ghrelin is a hormone suggested to play a role in meal initiation and to promote food intake. The present study explored the role of ghrelin in food-entrained conditions. Newborn rabbits were maintained in constant darkness and nursed once daily at 1000 by the lactating dam. On postnatal day 7 , rabbits were killed at six different time points to complete a 24-h cycle. All pups developed locomotor rhythms entrained by mealtime and exhibited anticipatory activity. Food-entrained rhythms in plasma corticosterone and free fatty acids were observed even if two meals were omitted. In contrast, daily food-driven rhythms in stomach weight, plasma glucose, liver glycogen, and ghrelin did not persist when two meals were omitted. Peak ghrelin levels were observed at the moment in the cycle when the stomach weight was lowest, i.e., before initiation of anticipation. The present data are in agreement with previous data from rabbit pups maintained in light-dark conditions and provide evidence that 7- to 9-day-old rabbits in constant darkness can exhibit metabolic and hormonal rhythms mainly driven by the restricted daily nursing.
food entrainment; corticosterone; ghrelin; development; circadian rhythms
Address for reprint requests and other correspondence: M. Caba, Lab. Biol. de la Reproducción, IIB, Universidad Veracruzana, AP 114, Xalapa 91000, Ver., Mexico (e-mail: mcaba{at}uv.mx ) |
| doi_str_mv | 10.1152/ajpregu.00162.2008 |
| format | Article |
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Submitted 3 March 2008
; accepted in final form 13 May 2008
Young rabbits are nursed every 24 h for a period of 3–5 min. As a consequence, pups are synchronized to this nursing event; this synchronization is characterized by increased locomotor activity and a peaking of core temperature and plasma corticosterone in anticipation of the daily meal. Ghrelin is a hormone suggested to play a role in meal initiation and to promote food intake. The present study explored the role of ghrelin in food-entrained conditions. Newborn rabbits were maintained in constant darkness and nursed once daily at 1000 by the lactating dam. On postnatal day 7 , rabbits were killed at six different time points to complete a 24-h cycle. All pups developed locomotor rhythms entrained by mealtime and exhibited anticipatory activity. Food-entrained rhythms in plasma corticosterone and free fatty acids were observed even if two meals were omitted. In contrast, daily food-driven rhythms in stomach weight, plasma glucose, liver glycogen, and ghrelin did not persist when two meals were omitted. Peak ghrelin levels were observed at the moment in the cycle when the stomach weight was lowest, i.e., before initiation of anticipation. The present data are in agreement with previous data from rabbit pups maintained in light-dark conditions and provide evidence that 7- to 9-day-old rabbits in constant darkness can exhibit metabolic and hormonal rhythms mainly driven by the restricted daily nursing.
food entrainment; corticosterone; ghrelin; development; circadian rhythms
Address for reprint requests and other correspondence: M. Caba, Lab. Biol. de la Reproducción, IIB, Universidad Veracruzana, AP 114, Xalapa 91000, Ver., Mexico (e-mail: mcaba{at}uv.mx )</description><identifier>ISSN: 0363-6119</identifier><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.00162.2008</identifier><identifier>PMID: 18480239</identifier><identifier>CODEN: AJPRDO</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Animals ; Animals, Newborn ; Behavior, Animal ; Blood Glucose - metabolism ; Body Temperature ; Circadian Rhythm ; Corticosterone - blood ; Energy Metabolism ; Fasting - metabolism ; Fatty acids ; Fatty Acids, Nonesterified - blood ; Feeding Behavior ; Female ; Ghrelin - blood ; Glycogen - metabolism ; Hormones ; Hormones - blood ; Lactation ; Liver - metabolism ; Maternal Behavior ; Metabolism ; Motor Activity ; Photoperiod ; Plasma ; Rabbits ; Sleep and Biological Rhythms ; Stomach - growth & development ; Studies</subject><ispartof>American journal of physiology. Regulatory, integrative and comparative physiology, 2008-08, Vol.295 (2), p.R690-R695</ispartof><rights>Copyright American Physiological Society Aug 2008</rights><rights>Copyright © 2008, American Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-97b7d6034a02ec7d4444f6324038e1fb703f85700d7a2adff0e9150282f4aa593</citedby><cites>FETCH-LOGICAL-c515t-97b7d6034a02ec7d4444f6324038e1fb703f85700d7a2adff0e9150282f4aa593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,778,782,883,3028,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18480239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morgado, Elvira</creatorcontrib><creatorcontrib>Gordon, M. Kathleen</creatorcontrib><creatorcontrib>del Carmen Minana-Solis, Maria</creatorcontrib><creatorcontrib>Meza, Enrique</creatorcontrib><creatorcontrib>Levine, Seymour</creatorcontrib><creatorcontrib>Escobar, Carolina</creatorcontrib><creatorcontrib>Caba, Mario</creatorcontrib><title>Hormonal and metabolic rhythms associated with the daily scheduled nursing in rabbit pups</title><title>American journal of physiology. Regulatory, integrative and comparative physiology</title><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><description>1 Laboratorio de Biología de la Reproducción, IIB, Universidad Veracruzana, Xalapa, Veracruz, México; 2 Department of Psychology, University of Delaware, Newark, Delaware; 3 Departamento de Anatomía, Facultad de Medicina, Universidad Nacional Autónoma de México, México DF, Mexico; and 4 Center for Neurosciences, University of California, Davis, California
Submitted 3 March 2008
; accepted in final form 13 May 2008
Young rabbits are nursed every 24 h for a period of 3–5 min. As a consequence, pups are synchronized to this nursing event; this synchronization is characterized by increased locomotor activity and a peaking of core temperature and plasma corticosterone in anticipation of the daily meal. Ghrelin is a hormone suggested to play a role in meal initiation and to promote food intake. The present study explored the role of ghrelin in food-entrained conditions. Newborn rabbits were maintained in constant darkness and nursed once daily at 1000 by the lactating dam. On postnatal day 7 , rabbits were killed at six different time points to complete a 24-h cycle. All pups developed locomotor rhythms entrained by mealtime and exhibited anticipatory activity. Food-entrained rhythms in plasma corticosterone and free fatty acids were observed even if two meals were omitted. In contrast, daily food-driven rhythms in stomach weight, plasma glucose, liver glycogen, and ghrelin did not persist when two meals were omitted. Peak ghrelin levels were observed at the moment in the cycle when the stomach weight was lowest, i.e., before initiation of anticipation. The present data are in agreement with previous data from rabbit pups maintained in light-dark conditions and provide evidence that 7- to 9-day-old rabbits in constant darkness can exhibit metabolic and hormonal rhythms mainly driven by the restricted daily nursing.
food entrainment; corticosterone; ghrelin; development; circadian rhythms
Address for reprint requests and other correspondence: M. Caba, Lab. Biol. de la Reproducción, IIB, Universidad Veracruzana, AP 114, Xalapa 91000, Ver., Mexico (e-mail: mcaba{at}uv.mx )</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Behavior, Animal</subject><subject>Blood Glucose - metabolism</subject><subject>Body Temperature</subject><subject>Circadian Rhythm</subject><subject>Corticosterone - blood</subject><subject>Energy Metabolism</subject><subject>Fasting - metabolism</subject><subject>Fatty acids</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Ghrelin - blood</subject><subject>Glycogen - metabolism</subject><subject>Hormones</subject><subject>Hormones - blood</subject><subject>Lactation</subject><subject>Liver - metabolism</subject><subject>Maternal Behavior</subject><subject>Metabolism</subject><subject>Motor Activity</subject><subject>Photoperiod</subject><subject>Plasma</subject><subject>Rabbits</subject><subject>Sleep and Biological Rhythms</subject><subject>Stomach - growth & development</subject><subject>Studies</subject><issn>0363-6119</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAUhS1ERYfCC7BAFgt2Ga7t_NgbJFRRilQJqWoXrCwndhKPnDjYTkvengwztIDUu7mL852jax-E3hDYElLQD2o3BdPNWwBS0i0F4M_QZhVoRnIBz9EGWMmykhBxil7GuAOAnOXsBTolPOdAmdig75c-DH5UDqtR48EkVXtnGxz6JfVDxCpG31iVjMb3NvU49QZrZd2CY9MbPbtVGOcQ7dhhO-Kg6tomPM1TfIVOWuWieX3cZ-j24vPN-WV29e3L1_NPV1lTkCJloqorXQLLFVDTVDpfpy0ZzYFxQ9q6AtbyogLQlaJKty0YQQqgnLa5UoVgZ-jjIXea68HoxowpKCenYAcVFumVlf8qo-1l5-8kLYgQtFoD3h8Dgv8xm5jkYGNjnFOj8XOUpcihqEq-gu_-A3d-DuvfRUmp4IRXfH8OPUBN8DEG0z5cQkDua5PH2uTv2uS-ttX09u83PFqOPa1AdgB62_X3Nhg59Uu03vlueQikopBUXpcCVl48zV_Mzt2Yn-mP8dEnJ92yXwi4u9k</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Morgado, Elvira</creator><creator>Gordon, M. Kathleen</creator><creator>del Carmen Minana-Solis, Maria</creator><creator>Meza, Enrique</creator><creator>Levine, Seymour</creator><creator>Escobar, Carolina</creator><creator>Caba, Mario</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080801</creationdate><title>Hormonal and metabolic rhythms associated with the daily scheduled nursing in rabbit pups</title><author>Morgado, Elvira ; Gordon, M. Kathleen ; del Carmen Minana-Solis, Maria ; Meza, Enrique ; Levine, Seymour ; Escobar, Carolina ; Caba, Mario</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-97b7d6034a02ec7d4444f6324038e1fb703f85700d7a2adff0e9150282f4aa593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Behavior, Animal</topic><topic>Blood Glucose - metabolism</topic><topic>Body Temperature</topic><topic>Circadian Rhythm</topic><topic>Corticosterone - blood</topic><topic>Energy Metabolism</topic><topic>Fasting - metabolism</topic><topic>Fatty acids</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Feeding Behavior</topic><topic>Female</topic><topic>Ghrelin - blood</topic><topic>Glycogen - metabolism</topic><topic>Hormones</topic><topic>Hormones - blood</topic><topic>Lactation</topic><topic>Liver - metabolism</topic><topic>Maternal Behavior</topic><topic>Metabolism</topic><topic>Motor Activity</topic><topic>Photoperiod</topic><topic>Plasma</topic><topic>Rabbits</topic><topic>Sleep and Biological Rhythms</topic><topic>Stomach - growth & development</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morgado, Elvira</creatorcontrib><creatorcontrib>Gordon, M. Kathleen</creatorcontrib><creatorcontrib>del Carmen Minana-Solis, Maria</creatorcontrib><creatorcontrib>Meza, Enrique</creatorcontrib><creatorcontrib>Levine, Seymour</creatorcontrib><creatorcontrib>Escobar, Carolina</creatorcontrib><creatorcontrib>Caba, Mario</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of physiology. 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Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>295</volume><issue>2</issue><spage>R690</spage><epage>R695</epage><pages>R690-R695</pages><issn>0363-6119</issn><eissn>1522-1490</eissn><coden>AJPRDO</coden><abstract>1 Laboratorio de Biología de la Reproducción, IIB, Universidad Veracruzana, Xalapa, Veracruz, México; 2 Department of Psychology, University of Delaware, Newark, Delaware; 3 Departamento de Anatomía, Facultad de Medicina, Universidad Nacional Autónoma de México, México DF, Mexico; and 4 Center for Neurosciences, University of California, Davis, California
Submitted 3 March 2008
; accepted in final form 13 May 2008
Young rabbits are nursed every 24 h for a period of 3–5 min. As a consequence, pups are synchronized to this nursing event; this synchronization is characterized by increased locomotor activity and a peaking of core temperature and plasma corticosterone in anticipation of the daily meal. Ghrelin is a hormone suggested to play a role in meal initiation and to promote food intake. The present study explored the role of ghrelin in food-entrained conditions. Newborn rabbits were maintained in constant darkness and nursed once daily at 1000 by the lactating dam. On postnatal day 7 , rabbits were killed at six different time points to complete a 24-h cycle. All pups developed locomotor rhythms entrained by mealtime and exhibited anticipatory activity. Food-entrained rhythms in plasma corticosterone and free fatty acids were observed even if two meals were omitted. In contrast, daily food-driven rhythms in stomach weight, plasma glucose, liver glycogen, and ghrelin did not persist when two meals were omitted. Peak ghrelin levels were observed at the moment in the cycle when the stomach weight was lowest, i.e., before initiation of anticipation. The present data are in agreement with previous data from rabbit pups maintained in light-dark conditions and provide evidence that 7- to 9-day-old rabbits in constant darkness can exhibit metabolic and hormonal rhythms mainly driven by the restricted daily nursing.
food entrainment; corticosterone; ghrelin; development; circadian rhythms
Address for reprint requests and other correspondence: M. Caba, Lab. Biol. de la Reproducción, IIB, Universidad Veracruzana, AP 114, Xalapa 91000, Ver., Mexico (e-mail: mcaba{at}uv.mx )</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>18480239</pmid><doi>10.1152/ajpregu.00162.2008</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | American journal of physiology. Regulatory, integrative and comparative physiology, 2008-08, Vol.295 (2), p.R690-R695 |
| issn | 0363-6119 1522-1490 |
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| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Animals, Newborn Behavior, Animal Blood Glucose - metabolism Body Temperature Circadian Rhythm Corticosterone - blood Energy Metabolism Fasting - metabolism Fatty acids Fatty Acids, Nonesterified - blood Feeding Behavior Female Ghrelin - blood Glycogen - metabolism Hormones Hormones - blood Lactation Liver - metabolism Maternal Behavior Metabolism Motor Activity Photoperiod Plasma Rabbits Sleep and Biological Rhythms Stomach - growth & development Studies |
| title | Hormonal and metabolic rhythms associated with the daily scheduled nursing in rabbit pups |
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