Exposure of differentiated airway smooth muscle cells to serum stimulates both induction of hypoxia-inducible factor-1α and airway responsiveness to ACh

Airway smooth muscle (ASM) cells are characterized by phenotypic plasticity and can switch between differentiated and proliferative phenotypes. In rabbit tracheal ASM cells that had been differentiated in vitro by serum starvation, readdition of FBS caused initiation of proliferation and induction o...

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Veröffentlicht in:American journal of physiology. Lung cellular and molecular physiology 2007-10, Vol.293 (4), p.L913-L922
Hauptverfasser: Chachami, Georgia, Hatziefthimiou, Apostolia, Liakos, Panagiotis, Ioannou, Maria G., Koukoulis, Georgios K., Bonanou, Sofia, Molyvdas, Paschalis-Adam, Simos, George, Paraskeva, Efrosyni
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Sprache:eng
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