Targeted transgenesis identifies G αs as the bottleneck in β 2 -adrenergic receptor cell signaling and physiological function in airway smooth muscle

G protein-coupled receptors are the most pervasive signaling superfamily in the body and act as receptors to endogenous agonists and drugs. For β-agonist-mediated bronchodilation, the receptor-G protein-effector network consists of the β 2 -adrenergic receptor (β 2 AR), G s , and adenylyl cyclase, e...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2014-11, Vol.307 (10), p.L775-L780
Hauptverfasser:	Wang, Wayne C. H., Pauer, Susan H., Smith, Dan'elle C., Dixon, Madison A., Disimile, David J., Panebra, Alfredo, An, Steven S., Camoretti-Mercado, Blanca, Liggett, Stephen B.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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