Limited functional and metabolic improvements in hypertrophic and healthy rat heart overexpressing the skeletal muscle isoform of SERCA1 by adenoviral gene transfer in vivo

Program in Integrative Cardiac Metabolism, Center for Cardiovascular Research, Departments of 1 Physiology and Biophysics and 2 Medicine, College of Medicine, University of Illinois, Chicago, Illinois Submitted 19 September 2008 ; accepted in final form 22 October 2008 Adenoviral gene transfer of sa...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2008-12, Vol.295 (6), p.H2483-H2494
Hauptverfasser:	O'Donnell, J. Michael, Fields, Aaron, Xu, Xianyao, Chowdhury, Shamim A. K, Geenen, David L, Bi, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Adenosine Triphosphate - metabolism Adenoviridae - genetics Adrenergic beta-Agonists - pharmacology Animals Calcium Calcium-Binding Proteins Cardiomegaly - diagnostic imaging Cardiomegaly - enzymology Cardiomegaly - genetics Cardiomegaly - therapy Carrier Proteins - metabolism Citric Acid Cycle Disease Models, Animal Energy Metabolism - drug effects Gene expression Gene Transfer Techniques Genetic Therapy Genetic Vectors Heart Hemodynamics Isoproterenol - pharmacology Magnetic Resonance Spectroscopy Male Mitochondria, Heart - metabolism Muscle, Skeletal - enzymology Musculoskeletal system Myocardial Contraction - drug effects Myocardium - enzymology Myocardium - pathology Oxidation-Reduction Palmitic Acid - metabolism Phosphocreatine - metabolism Rats Rats, Sprague-Dawley Rodents Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism Studies Time Factors Ultrasonography
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