Gene transfer of extracellular SOD to the penis reduces O 2 − · and improves erectile function in aged rats

Increased superoxide anion (O[Formula: see text]·) may contribute to vascular dysfunction in aging. In aged cavernosal tissue, lucigenin-enhanced chemiluminescence demonstrated a threefold increase in superoxide formation, and the oxidative fluorescent probe hydroethidine indicated higher superoxide...

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Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 2003-04, Vol.284 (4), p.H1408-H1421
Hauptverfasser: Bivalacqua, Trinity J., Armstrong, Jeffrey S., Biggerstaff, John, Abdel-Mageed, Asim B., Kadowitz, Philip J., Hellstrom, Wayne J. G., Champion, Hunter C.
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Sprache:eng
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