Pannexin 1 channels control the hemodynamic response to hypoxia by regulating O 2 -sensitive extracellular ATP in blood

Pannexin 1 (Panx1) channels export ATP and may contribute to increased concentration of the vasodilator ATP in plasma during hypoxia in vivo. We hypothesized that Panx1 channels and associated ATP export contribute to hypoxic vasodilation, a mechanism that facilitates the matching of oxygen delivery...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2021-03, Vol.320 (3), p.H1055-H1065
Hauptverfasser:	Kirby, Brett S, Sparks, Matthew A, Lazarowski, Eduardo R, Lopez Domowicz, Denise A, Zhu, Hongmei, McMahon, Timothy J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - blood Animals Arterial Pressure Connexins - blood Connexins - deficiency Connexins - genetics Disease Models, Animal Erythrocytes - metabolism Female Heart Rate Hemodynamics Hindlimb - blood supply Hyperemia - blood Hyperemia - genetics Hyperemia - physiopathology Hypotension - blood Hypotension - genetics Hypotension - physiopathology Hypoxia - blood Hypoxia - genetics Hypoxia - physiopathology Male Mice Mice, Inbred C57BL Mice, Knockout Nerve Tissue Proteins - blood Nerve Tissue Proteins - deficiency Nerve Tissue Proteins - genetics Oxygen - blood Regional Blood Flow Vasodilation
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