A novel role for PGE 2 -EP 4 in the developmental programming of the mouse ductus arteriosus: consequences for vessel maturation and function

The ductus arteriosus (DA) is a vascular shunt that allows oxygenated blood to bypass the developing lungs in utero. Fetal DA patency requires vasodilatory signaling via the prostaglandin E (PGE ) receptor EP . However, in humans and mice, disrupted PGE -EP signaling in utero causes unexpected paten...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2023-10, Vol.325 (4), p.H687-H701
Hauptverfasser:	Yarboro, Michael T, Boatwright, Naoko, Sekulich, Deanna C, Hooper, Christopher W, Wong, Ting, Poole, Stanley D, Berger, Courtney D, Brown, Alexus J, Jetter, Christopher S, Sucre, Jennifer M S, Shelton, Elaine L, Reese, Jeff
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dinoprostone - metabolism Ductus Arteriosus - metabolism Ductus Arteriosus, Patent - genetics Female Humans Infant, Newborn Mice Mice, Knockout Pregnancy Receptors, Prostaglandin E, EP4 Subtype - genetics Receptors, Prostaglandin E, EP4 Subtype - metabolism
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