Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse

Adenosine protects the heart from adrenergic overstimulation. This adenoprotection includes the direct anti-adrenergic action via adenosine A(1) receptors (A(1)R) on the adrenergic signaling pathway. An indirect A(1)R-induced attenuation of adrenergic responsiveness involves the translocation of PKC...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2009-08, Vol.297 (2), p.H718-H725
Hauptverfasser:	Fenton, Richard A, Komatsu, Satoshi, Ikebe, Mitsuo, Shea, Lynne G, Dobson, Jr, James G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Adenosine A1 Receptor Agonists Adenosine A1 Receptor Antagonists Age Factors Animals Antibodies - pharmacology Cells, Cultured Coatomer Protein - immunology Coatomer Protein - metabolism Estrenes - pharmacology Immunohistochemistry Immunoprecipitation Male Membrane Proteins - immunology Membrane Proteins - metabolism Mice Mice, Inbred C57BL Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - enzymology Phosphodiesterase Inhibitors - pharmacology Protein Kinase C-epsilon - metabolism Pyrrolidinones - pharmacology Rats Rats, Sprague-Dawley Receptor, Adenosine A1 - metabolism Type C Phospholipases - antagonists & inhibitors Xanthines - pharmacology
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