ET-1 induces cortical spreading depression via activation of the ET A receptor/phospholipase C pathway in vivo

Recently, it has been shown that brain topical superfusion of endothelin (ET)-1 at concentrations around 100 nM induces repetitive cortical spreading depressions (CSDs) in vivo. It has remained unclear whether this effect of ET-1 is related to a primary neuronal/astroglial effect, such as an increas...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2004-04, Vol.286 (4), p.H1339-H1346
Hauptverfasser:	Kleeberg, Jörg, Petzold, Gabor C., Major, Sebastian, Dirnagl, Ulrich, Dreier, Jens P.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!