Fluid shear stress induces upregulation of COX-2 and PGI 2 release in endothelial cells via a pathway involving PECAM-1, PI3K, FAK, and p38

Vascular endothelial cells play an important role in the regulation of vascular function in response to mechanical stimuli in both healthy and diseased states. Prostaglandin I (PGI ) is an important antiatherogenic prostanoid and vasodilator produced in endothelial cells through the action of the cy...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2017-03, Vol.312 (3), p.H485-H500
Hauptverfasser:	Russell-Puleri, Sparkle, Dela Paz, Nathaniel G, Adams, Diana, Chattopadhyay, Mitali, Cancel, Limary, Ebong, Eno, Orr, A Wayne, Frangos, John A, Tarbell, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Cell Line Cilia - metabolism Cyclooxygenase 2 - biosynthesis Endothelial Cells - metabolism Epoprostenol - biosynthesis Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Immunohistochemistry Integrins - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Peptides - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Signal Transduction - physiology Stress, Mechanical Up-Regulation
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