Differential cardioprotective/cardiotoxic effects mediated by beta-adrenergic receptor subtypes

Recent data suggest that beta-adrenergic receptor subtypes couple differentially to signaling pathways regulating cardiac function vs. cardiac remodeling. To dissect the roles of beta1- vs. beta2-receptors in the pathogenesis of cardiomyopathy, doxorubicin was administered to beta1, beta2, and beta1...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2005-12, Vol.289 (6), p.H2441-H2449
Hauptverfasser:	Bernstein, Daniel, Fajardo, Giovanni, Zhao, Mingming, Urashima, Takashi, Powers, Jennifer, Berry, Gerald, Kobilka, Brian K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure Cardiomyopathy, Dilated - physiopathology Cardiotonic Agents Heart Rate Mice Mice, Knockout Receptors, Adrenergic, beta-1 - metabolism Receptors, Adrenergic, beta-2 - metabolism Survival Rate
Online-Zugang:	Volltext
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