The CDX2 transcription factor regulates furin expression during intestinal epithelial cell differentiation

CDX2, a member of the caudal family of transcription factors, is involved in enterocyte lineage specification. CDX2 activates many intestine-specific genes, such as sucrase-isomaltase and lactase-phlorizin hydrolase (LPH), and adhesion proteins, namely, LI-cadherin and claudin-2. In this study, we s...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2006-02, Vol.290 (2), p.G310-G318
Hauptverfasser:	Gendron, Fernand-Pierre, Mongrain, Sébastien, Laprise, Patrick, McMahon, Stéphanie, Dubois, Claire M, Blais, Mylène, Asselin, Claude, Rivard, Nathalie
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - metabolism Animals Blotting, Northern CDX2 Transcription Factor Cell Differentiation - genetics Cell Differentiation - physiology Cell Line Chromatin - genetics DNA - biosynthesis DNA - genetics Electrophoretic Mobility Shift Assay Enzyme Inhibitors - pharmacology Epithelial Cells - physiology Epithelial Cells - ultrastructure Furin - biosynthesis Furin - genetics Homeodomain Proteins - genetics Homeodomain Proteins - physiology Humans In Situ Hybridization Intestines - metabolism Intestines - ultrastructure Luciferases - genetics Microscopy, Electron Oligonucleotide Array Sequence Analysis Purines - pharmacology Rats Retroviridae - genetics Trans-Activators - genetics Trans-Activators - physiology Transfection
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