Bile salt exposure increases proliferation through p38 and ERK MAPK pathways in a non-neoplastic Barrett's cell line

Bile reflux has been implicated in the neoplastic progression of Barrett's esophagus (BE). Bile salts increase proliferation in a Barrett's-associated adenocarcinoma cell line (SEG-1 cells) by activating ERK and p38 MAPK pathways. However, it is not clear that these findings in cancer cell...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2006-02, Vol.290 (2), p.G335-G342
Hauptverfasser:	Jaiswal, Kshama, Lopez-Guzman, Christie, Souza, Rhonda F, Spechler, Stuart J, Sarosi, Jr, George A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Annexin A5 - metabolism Antimetabolites Apoptosis - drug effects Barrett Esophagus - metabolism Bile Acids and Salts - pharmacology Blotting, Western Bromodeoxyuridine Cell Count Cell Line Cell Line, Tumor Cell Proliferation - drug effects Esophageal Neoplasms - metabolism Esophagus - cytology Esophagus - drug effects Esophagus - metabolism Humans In Situ Nick-End Labeling Mitogen-Activated Protein Kinases - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation
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