Prolonged β 2 -adrenergic agonist treatment improves glucose homeostasis in diet-induced obese UCP1 -/- mice

Prolonged supplementation with the β -agonist clenbuterol improves glucose homeostasis in diabetic rodents, likely via β -adrenoceptor (β -AR)-mediated effects in the skeletal muscle and liver. However, since rodents have, in contrast to-especially diabetic-humans, substantial quantities of brown ad...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2021-03, Vol.320 (3), p.E619-E628
Hauptverfasser:	van Beek, Sten M M, Kalinovich, Anastasia, Schaart, Gert, Bengtsson, Tore, Hoeks, Joris
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue, Brown - metabolism Adrenergic beta-2 Receptor Agonists - administration & dosage Adrenergic beta-2 Receptor Agonists - pharmacology Animals Clenbuterol - administration & dosage Clenbuterol - pharmacology Diet, High-Fat Drug Administration Schedule Glucose - metabolism Glucose Intolerance - drug therapy Glucose Intolerance - genetics Glucose Intolerance - metabolism Homeostasis - genetics Insulin Resistance - genetics Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Obese Obesity - drug therapy Obesity - etiology Obesity - metabolism Obesity - pathology Receptors, Adrenergic, beta-2 - metabolism Thermogenesis - drug effects Thermogenesis - genetics Time Factors Uncoupling Protein 1 - deficiency Uncoupling Protein 1 - genetics
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