Regulation of exercise carbohydrate metabolism by estrogen and progesterone in women
1 Department of Exercise Science, University of Massachusetts, Amherst 01003; 2 Division of Endocrinology, Diabetes and Metabolism and 3 Department of Obstetrics and Gynecology, Baystate Medical Center, Springfield, Massachusetts 01199; and 4 Department of Health and Human Performance, Universit...
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| Veröffentlicht in: | American journal of physiology: endocrinology and metabolism 2002-11, Vol.283 (5), p.E1046-E1055 |
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| container_title | American journal of physiology: endocrinology and metabolism |
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| creator | D'Eon, Tara M Sharoff, Carrie Chipkin, Stuart R Grow, Dan Ruby, Brent C Braun, Barry |
| description | 1 Department of Exercise Science, University of
Massachusetts, Amherst 01003; 2 Division of
Endocrinology, Diabetes and Metabolism and 3 Department
of Obstetrics and Gynecology, Baystate Medical Center, Springfield,
Massachusetts 01199; and 4 Department of
Health and Human Performance, University of Montana, Missoula,
Montana 59813
To assess the roles of endogenous estrogen
(E 2 ) and progesterone (P 4 ) in regulating
exercise carbohydrate use, we used pharmacological suppression and
replacement to create three distinct hormonal environments: baseline
(B), with E 2 and P 4 low; estrogen only (E),
with E 2 high and P 4 low; and
estrogen/progesterone (E + P), with E 2 and P 4
high. Blood glucose uptake (R d ), total carbohydrate oxidation (CHO ox ), and estimated muscle glycogen
utilization (EMGU) were assessed during 60 min of submaximal exercise
by use of stable isotope dilution and indirect calorimetry in eight
eumenorrheic women. Compared with B (1.26 ± 0.04 g/min) and E + P
(1.27 ± 0.04 g/min), CHO ox was lower with E
(1.05 ± 0.02 g/min). Glucose R d tended to be lower
with E and E + P relative to B. EMGU was 25% lower with E than with B
or E + P. Plasma free fatty acids (FFA) were inversely related to EMGU
( r 2 = 0.49). The data suggest that estrogen
lowers CHO ox by reducing EMGU and glucose R d .
Progesterone increases EMGU but not glucose R d . The
opposing actions of E 2 and P 4 on EMGU may be
mediated by their impact on FFA availability or vice versa.
ovarian hormones; menstrual cycle; fat oxidation; stable isotope; glycogen |
| doi_str_mv | 10.1152/ajpendo.00271.2002 |
| format | Article |
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Massachusetts, Amherst 01003; 2 Division of
Endocrinology, Diabetes and Metabolism and 3 Department
of Obstetrics and Gynecology, Baystate Medical Center, Springfield,
Massachusetts 01199; and 4 Department of
Health and Human Performance, University of Montana, Missoula,
Montana 59813
To assess the roles of endogenous estrogen
(E 2 ) and progesterone (P 4 ) in regulating
exercise carbohydrate use, we used pharmacological suppression and
replacement to create three distinct hormonal environments: baseline
(B), with E 2 and P 4 low; estrogen only (E),
with E 2 high and P 4 low; and
estrogen/progesterone (E + P), with E 2 and P 4
high. Blood glucose uptake (R d ), total carbohydrate oxidation (CHO ox ), and estimated muscle glycogen
utilization (EMGU) were assessed during 60 min of submaximal exercise
by use of stable isotope dilution and indirect calorimetry in eight
eumenorrheic women. Compared with B (1.26 ± 0.04 g/min) and E + P
(1.27 ± 0.04 g/min), CHO ox was lower with E
(1.05 ± 0.02 g/min). Glucose R d tended to be lower
with E and E + P relative to B. EMGU was 25% lower with E than with B
or E + P. Plasma free fatty acids (FFA) were inversely related to EMGU
( r 2 = 0.49). The data suggest that estrogen
lowers CHO ox by reducing EMGU and glucose R d .
Progesterone increases EMGU but not glucose R d . The
opposing actions of E 2 and P 4 on EMGU may be
mediated by their impact on FFA availability or vice versa.
ovarian hormones; menstrual cycle; fat oxidation; stable isotope; glycogen</description><identifier>ISSN: 0193-1849</identifier><identifier>EISSN: 1522-1555</identifier><identifier>DOI: 10.1152/ajpendo.00271.2002</identifier><identifier>PMID: 12376334</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Adult ; Blood Glucose - metabolism ; Carbohydrate Metabolism ; Energy Metabolism - drug effects ; Energy Metabolism - physiology ; Epinephrine - blood ; Estrogens - administration & dosage ; Exercise - physiology ; Fatty Acids, Nonesterified - blood ; Female ; Glycogen - metabolism ; Humans ; Insulin - blood ; Lactic Acid - blood ; Menstrual Cycle - physiology ; Norepinephrine - blood ; Oxidation-Reduction ; Oxygen Consumption - drug effects ; Oxygen Consumption - physiology ; Progesterone - administration & dosage ; Rest - physiology</subject><ispartof>American journal of physiology: endocrinology and metabolism, 2002-11, Vol.283 (5), p.E1046-E1055</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-b181a51b7edfe16ff9674dbac980cc20acf974ee6249962e77e2bdc37b68b1a63</citedby><cites>FETCH-LOGICAL-c486t-b181a51b7edfe16ff9674dbac980cc20acf974ee6249962e77e2bdc37b68b1a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3025,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12376334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>D'Eon, Tara M</creatorcontrib><creatorcontrib>Sharoff, Carrie</creatorcontrib><creatorcontrib>Chipkin, Stuart R</creatorcontrib><creatorcontrib>Grow, Dan</creatorcontrib><creatorcontrib>Ruby, Brent C</creatorcontrib><creatorcontrib>Braun, Barry</creatorcontrib><title>Regulation of exercise carbohydrate metabolism by estrogen and progesterone in women</title><title>American journal of physiology: endocrinology and metabolism</title><addtitle>Am J Physiol Endocrinol Metab</addtitle><description>1 Department of Exercise Science, University of
Massachusetts, Amherst 01003; 2 Division of
Endocrinology, Diabetes and Metabolism and 3 Department
of Obstetrics and Gynecology, Baystate Medical Center, Springfield,
Massachusetts 01199; and 4 Department of
Health and Human Performance, University of Montana, Missoula,
Montana 59813
To assess the roles of endogenous estrogen
(E 2 ) and progesterone (P 4 ) in regulating
exercise carbohydrate use, we used pharmacological suppression and
replacement to create three distinct hormonal environments: baseline
(B), with E 2 and P 4 low; estrogen only (E),
with E 2 high and P 4 low; and
estrogen/progesterone (E + P), with E 2 and P 4
high. Blood glucose uptake (R d ), total carbohydrate oxidation (CHO ox ), and estimated muscle glycogen
utilization (EMGU) were assessed during 60 min of submaximal exercise
by use of stable isotope dilution and indirect calorimetry in eight
eumenorrheic women. Compared with B (1.26 ± 0.04 g/min) and E + P
(1.27 ± 0.04 g/min), CHO ox was lower with E
(1.05 ± 0.02 g/min). Glucose R d tended to be lower
with E and E + P relative to B. EMGU was 25% lower with E than with B
or E + P. Plasma free fatty acids (FFA) were inversely related to EMGU
( r 2 = 0.49). The data suggest that estrogen
lowers CHO ox by reducing EMGU and glucose R d .
Progesterone increases EMGU but not glucose R d . The
opposing actions of E 2 and P 4 on EMGU may be
mediated by their impact on FFA availability or vice versa.
ovarian hormones; menstrual cycle; fat oxidation; stable isotope; glycogen</description><subject>Adolescent</subject><subject>Adult</subject><subject>Blood Glucose - metabolism</subject><subject>Carbohydrate Metabolism</subject><subject>Energy Metabolism - drug effects</subject><subject>Energy Metabolism - physiology</subject><subject>Epinephrine - blood</subject><subject>Estrogens - administration & dosage</subject><subject>Exercise - physiology</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Female</subject><subject>Glycogen - metabolism</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Lactic Acid - blood</subject><subject>Menstrual Cycle - physiology</subject><subject>Norepinephrine - blood</subject><subject>Oxidation-Reduction</subject><subject>Oxygen Consumption - drug effects</subject><subject>Oxygen Consumption - physiology</subject><subject>Progesterone - administration & dosage</subject><subject>Rest - physiology</subject><issn>0193-1849</issn><issn>1522-1555</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFq3DAURUVpaKbT_kAXRavuPNGTbMnOLoSkLQQKZboWkvw8o2BbjmST-O_ryUxoNiWrJ9A9l8sh5AuwDUDBL8z9gH0dNoxxBRu-nHdktXzwDIqieE9WDCqRQZlX5-RjSveMMVXk_AM5By6UFCJfke1v3E2tGX3oaWgoPmF0PiF1Jtqwn-toRqQdjsaG1qeO2pliGmPYYU9NX9Ph8EwjxtAj9T19DB32n8hZY9qEn093Tf7c3myvf2R3v77_vL66y1xeyjGzUIIpwCqsGwTZNJVUeW2Nq0rmHGfGNZXKESXPq0pyVAq5rZ1QVpYWjBRr8u3Yu6x4mJYZuvPJYduaHsOUtOKgBIi3g6CYUGwxsib8GHQxpBSx0UP0nYmzBqYP0vVJun6Wrg_SF-jrqX2yHdb_kJPlJXB5DOz9bv_oI-phPycf2rCb9e3Utlt8Gl-aeSl0oW-A5VIPdbPAm__DL2teQeIv28imMg</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>D'Eon, Tara M</creator><creator>Sharoff, Carrie</creator><creator>Chipkin, Stuart R</creator><creator>Grow, Dan</creator><creator>Ruby, Brent C</creator><creator>Braun, Barry</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Regulation of exercise carbohydrate metabolism by estrogen and progesterone in women</title><author>D'Eon, Tara M ; Sharoff, Carrie ; Chipkin, Stuart R ; Grow, Dan ; Ruby, Brent C ; Braun, Barry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-b181a51b7edfe16ff9674dbac980cc20acf974ee6249962e77e2bdc37b68b1a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Blood Glucose - metabolism</topic><topic>Carbohydrate Metabolism</topic><topic>Energy Metabolism - drug effects</topic><topic>Energy Metabolism - physiology</topic><topic>Epinephrine - blood</topic><topic>Estrogens - administration & dosage</topic><topic>Exercise - physiology</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Female</topic><topic>Glycogen - metabolism</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Lactic Acid - blood</topic><topic>Menstrual Cycle - physiology</topic><topic>Norepinephrine - blood</topic><topic>Oxidation-Reduction</topic><topic>Oxygen Consumption - drug effects</topic><topic>Oxygen Consumption - physiology</topic><topic>Progesterone - administration & dosage</topic><topic>Rest - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>D'Eon, Tara M</creatorcontrib><creatorcontrib>Sharoff, Carrie</creatorcontrib><creatorcontrib>Chipkin, Stuart R</creatorcontrib><creatorcontrib>Grow, Dan</creatorcontrib><creatorcontrib>Ruby, Brent C</creatorcontrib><creatorcontrib>Braun, Barry</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology: endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>D'Eon, Tara M</au><au>Sharoff, Carrie</au><au>Chipkin, Stuart R</au><au>Grow, Dan</au><au>Ruby, Brent C</au><au>Braun, Barry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of exercise carbohydrate metabolism by estrogen and progesterone in women</atitle><jtitle>American journal of physiology: endocrinology and metabolism</jtitle><addtitle>Am J Physiol Endocrinol Metab</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>283</volume><issue>5</issue><spage>E1046</spage><epage>E1055</epage><pages>E1046-E1055</pages><issn>0193-1849</issn><eissn>1522-1555</eissn><abstract>1 Department of Exercise Science, University of
Massachusetts, Amherst 01003; 2 Division of
Endocrinology, Diabetes and Metabolism and 3 Department
of Obstetrics and Gynecology, Baystate Medical Center, Springfield,
Massachusetts 01199; and 4 Department of
Health and Human Performance, University of Montana, Missoula,
Montana 59813
To assess the roles of endogenous estrogen
(E 2 ) and progesterone (P 4 ) in regulating
exercise carbohydrate use, we used pharmacological suppression and
replacement to create three distinct hormonal environments: baseline
(B), with E 2 and P 4 low; estrogen only (E),
with E 2 high and P 4 low; and
estrogen/progesterone (E + P), with E 2 and P 4
high. Blood glucose uptake (R d ), total carbohydrate oxidation (CHO ox ), and estimated muscle glycogen
utilization (EMGU) were assessed during 60 min of submaximal exercise
by use of stable isotope dilution and indirect calorimetry in eight
eumenorrheic women. Compared with B (1.26 ± 0.04 g/min) and E + P
(1.27 ± 0.04 g/min), CHO ox was lower with E
(1.05 ± 0.02 g/min). Glucose R d tended to be lower
with E and E + P relative to B. EMGU was 25% lower with E than with B
or E + P. Plasma free fatty acids (FFA) were inversely related to EMGU
( r 2 = 0.49). The data suggest that estrogen
lowers CHO ox by reducing EMGU and glucose R d .
Progesterone increases EMGU but not glucose R d . The
opposing actions of E 2 and P 4 on EMGU may be
mediated by their impact on FFA availability or vice versa.
ovarian hormones; menstrual cycle; fat oxidation; stable isotope; glycogen</abstract><cop>United States</cop><pmid>12376334</pmid><doi>10.1152/ajpendo.00271.2002</doi></addata></record> |
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| identifier | ISSN: 0193-1849 |
| ispartof | American journal of physiology: endocrinology and metabolism, 2002-11, Vol.283 (5), p.E1046-E1055 |
| issn | 0193-1849 1522-1555 |
| language | eng |
| recordid | cdi_crossref_primary_10_1152_ajpendo_00271_2002 |
| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Blood Glucose - metabolism Carbohydrate Metabolism Energy Metabolism - drug effects Energy Metabolism - physiology Epinephrine - blood Estrogens - administration & dosage Exercise - physiology Fatty Acids, Nonesterified - blood Female Glycogen - metabolism Humans Insulin - blood Lactic Acid - blood Menstrual Cycle - physiology Norepinephrine - blood Oxidation-Reduction Oxygen Consumption - drug effects Oxygen Consumption - physiology Progesterone - administration & dosage Rest - physiology |
| title | Regulation of exercise carbohydrate metabolism by estrogen and progesterone in women |
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