Cell-specific posttranscriptional regulation of CFTR gene expression via influence of MAPK cascades on 3′UTR part of transcripts

Expression of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene, which contains the mutations responsible for CF, is regulated by cytokines (TNF-α and IL-1β) in a cell-specific manner. TNF-α decreases CFTR mRNA in human colon cell lines (HT-29), but not in pulmonary cell lines...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2005-11, Vol.289 (5), p.C1240-C1250
Hauptverfasser:	Baudouin-Legros, Maryvonne, Hinzpeter, Alexandre, Jaulmes, Amandine, Brouillard, Franck, Costes, Bruno, Fanen, Pascale, Edelman, Aleksander
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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