Structural elements of kallistatin required for inhibition of angiogenesis

Kallistatin is a serpin first identified as a specific inhibitor of tissue kallikrein. Our recent studies showed that kallikrein promoted angiogenesis, whereas kallistatin inhibited angiogenesis and tumor growth. This study is aimed to identify the structural elements of kallistatin essential for it...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2003-06, Vol.284 (6), p.C1604-C1613
Hauptverfasser:	Miao, Robert Q, Chen, Vincent, Chao, Lee, Chao, Julie
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism Cell Division - physiology Cell Movement - physiology Cells, Cultured Collagen Drug Combinations Endothelial Growth Factors - metabolism Endothelium, Vascular - cytology Endothelium, Vascular - physiology Humans Intercellular Signaling Peptides and Proteins - metabolism Kallikreins - antagonists & inhibitors Kallikreins - metabolism Laminin Lymphokines - metabolism Macromolecular Substances Male Mice Molecular Sequence Data Mutagenesis, Site-Directed Neovascularization, Physiologic Protein Binding Proteoglycans Recombinant Proteins - genetics Recombinant Proteins - metabolism Serpins - chemistry Serpins - genetics Serpins - metabolism Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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