Prolonged exposure to methylglyoxal causes disruption of vascular K ATP channel by mRNA instability

Diabetes mellitus is characterized by hyperglycemia and excessive production of intermediary metabolites including methylglyoxal (MGO), a reactive carbonyl species that can lead to cell injuries. Interacting with proteins, lipids, and DNA, excessive MGO can cause dysfunction of various tissues, espe...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2012-11, Vol.303 (10), p.C1045-C1054
Hauptverfasser:	Yang, Yang, Li, Shanshan, Konduru, Anuhya S., Zhang, Shuang, Trower, Timothy C., Shi, Weiwei, Cui, Ningren, Yu, Lei, Wang, Yali, Zhu, Daling, Jiang, Chun
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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