A Novel Electrochemical-Biosensor Microchip Based on MWCNTs/AuNPs for Detection of Glycated Hemoglobin (HbA1c) in Diabetes Patients
This study reports an electrochemical sensor based on multiwalled carbon nanotubes/gold nanoparticles (MWCNTs/AuNPs) for detection of total hemoglobin (Hb) and glycated hemoglobin (HbA1c) in blood samples. Measurement of glycated hemoglobin percentage (%HbA1c) is crucial to the monitoring of glycemi...
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| Veröffentlicht in: | Journal of the Electrochemical Society 2022-03, Vol.169 (3), p.37520 |
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| creator | Ponsanti, Khanittha Ngernyuang, Nipaporn Tangnorawich, Benchamaporn Na-Bangchang, Kesara Boonprasert, Kanyarat Tasanarong, Adis Saeheng, Teerachat Hanwattanakul, Akkaracha Pechyen, Chiravoot |
| description | This study reports an electrochemical sensor based on multiwalled carbon nanotubes/gold nanoparticles (MWCNTs/AuNPs) for detection of total hemoglobin (Hb) and glycated hemoglobin (HbA1c) in blood samples. Measurement of glycated hemoglobin percentage (%HbA1c) is crucial to the monitoring of glycemia in diabetes patients. The %HbA1c, which refers to the concentration ratio of HbA1c to total hemoglobin (Hb), has been widely used for accurate determination of stage-wise diabetes. The gold nanoparticles (AuNPs) used in the sensor were synthesized using a biological method employing passion fruit peel extracts. The resulting AuNPs are spherical with diameter approximately 18 nm, and these can be mixed with MWCNTs in various ratios to form MWCNTs/AuNPs composites. TEM imaging indicates that gold nanoparticles decorate the surface of the MWCNTs. Coating of a screen-printed carbon electrode (SPCE) with MWCNTs/AuNPs affords the novel MWCNTs/AuNPs/SPCE electrode, which exhibits a linear response over a 0.186–2.044 g dl
−1
HbA1c concentration range, with the correlation value of 0.96. The electrode can reliably be utilized for detection of total Hb and HbA1c in blood samples, which highlights its promise as a reliable approach for sensitive point-of-care testing (POCT) of HbA1c in diabetes patients. |
| doi_str_mv | 10.1149/1945-7111/ac5c0a |
| format | Article |
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−1
HbA1c concentration range, with the correlation value of 0.96. The electrode can reliably be utilized for detection of total Hb and HbA1c in blood samples, which highlights its promise as a reliable approach for sensitive point-of-care testing (POCT) of HbA1c in diabetes patients.</description><identifier>ISSN: 0013-4651</identifier><identifier>EISSN: 1945-7111</identifier><identifier>DOI: 10.1149/1945-7111/ac5c0a</identifier><identifier>CODEN: JESOAN</identifier><language>eng</language><publisher>IOP Publishing</publisher><ispartof>Journal of the Electrochemical Society, 2022-03, Vol.169 (3), p.37520</ispartof><rights>2022 The Author(s). Published on behalf of The Electrochemical Society by IOP Publishing Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c285t-4d8a83b68a7abb698b076845c43ab9c62a7685c823a5a9612459910e789490a63</citedby><cites>FETCH-LOGICAL-c285t-4d8a83b68a7abb698b076845c43ab9c62a7685c823a5a9612459910e789490a63</cites><orcidid>0000-0001-6034-6597</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://iopscience.iop.org/article/10.1149/1945-7111/ac5c0a/pdf$$EPDF$$P50$$Giop$$Hfree_for_read</linktopdf><link.rule.ids>314,780,784,27924,27925,53846</link.rule.ids></links><search><creatorcontrib>Ponsanti, Khanittha</creatorcontrib><creatorcontrib>Ngernyuang, Nipaporn</creatorcontrib><creatorcontrib>Tangnorawich, Benchamaporn</creatorcontrib><creatorcontrib>Na-Bangchang, Kesara</creatorcontrib><creatorcontrib>Boonprasert, Kanyarat</creatorcontrib><creatorcontrib>Tasanarong, Adis</creatorcontrib><creatorcontrib>Saeheng, Teerachat</creatorcontrib><creatorcontrib>Hanwattanakul, Akkaracha</creatorcontrib><creatorcontrib>Pechyen, Chiravoot</creatorcontrib><title>A Novel Electrochemical-Biosensor Microchip Based on MWCNTs/AuNPs for Detection of Glycated Hemoglobin (HbA1c) in Diabetes Patients</title><title>Journal of the Electrochemical Society</title><addtitle>JES</addtitle><addtitle>J. Electrochem. Soc</addtitle><description>This study reports an electrochemical sensor based on multiwalled carbon nanotubes/gold nanoparticles (MWCNTs/AuNPs) for detection of total hemoglobin (Hb) and glycated hemoglobin (HbA1c) in blood samples. Measurement of glycated hemoglobin percentage (%HbA1c) is crucial to the monitoring of glycemia in diabetes patients. The %HbA1c, which refers to the concentration ratio of HbA1c to total hemoglobin (Hb), has been widely used for accurate determination of stage-wise diabetes. The gold nanoparticles (AuNPs) used in the sensor were synthesized using a biological method employing passion fruit peel extracts. The resulting AuNPs are spherical with diameter approximately 18 nm, and these can be mixed with MWCNTs in various ratios to form MWCNTs/AuNPs composites. TEM imaging indicates that gold nanoparticles decorate the surface of the MWCNTs. Coating of a screen-printed carbon electrode (SPCE) with MWCNTs/AuNPs affords the novel MWCNTs/AuNPs/SPCE electrode, which exhibits a linear response over a 0.186–2.044 g dl
−1
HbA1c concentration range, with the correlation value of 0.96. The electrode can reliably be utilized for detection of total Hb and HbA1c in blood samples, which highlights its promise as a reliable approach for sensitive point-of-care testing (POCT) of HbA1c in diabetes patients.</description><issn>0013-4651</issn><issn>1945-7111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>O3W</sourceid><recordid>eNp1kM9PwjAUxxujiYjePfaIiZN2a7f2OAHBBJADxmPzVjotGStZhwln_3G7YDzp6f36fF_e-yJ0S8kDpUwOqWQ8yiilQ9BcEzhDvd_WOeoRQpOIpZxeoivvt6GkgmU99JXjpfs0FZ5URreN0x9mZzVU0aN13tTeNXhhdde3e_wI3mywq_HibbRc-2F-WK48LgMzNm2Q2zByJZ5WRw1tIGdm594rV9gaD2ZFTvUdDunYQhFwj1fQWlO3_hpdlFB5c_MT--j1abIezaL5y_R5lM8jHQveRmwjQCRFKiCDokilKEiWCsY1S6CQOo0hlFyLOAEOMqUx41JSYjIhmSSQJn1ETnvDP943plT7xu6gOSpKVGei6hxTnWPqZGKQDE4S6_Zq6w5NHQ5UW-MVTaVKFEkyHhO135QBvf8D_XfzN3lugAA</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Ponsanti, Khanittha</creator><creator>Ngernyuang, Nipaporn</creator><creator>Tangnorawich, Benchamaporn</creator><creator>Na-Bangchang, Kesara</creator><creator>Boonprasert, Kanyarat</creator><creator>Tasanarong, Adis</creator><creator>Saeheng, Teerachat</creator><creator>Hanwattanakul, Akkaracha</creator><creator>Pechyen, Chiravoot</creator><general>IOP Publishing</general><scope>O3W</scope><scope>TSCCA</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-6034-6597</orcidid></search><sort><creationdate>20220301</creationdate><title>A Novel Electrochemical-Biosensor Microchip Based on MWCNTs/AuNPs for Detection of Glycated Hemoglobin (HbA1c) in Diabetes Patients</title><author>Ponsanti, Khanittha ; Ngernyuang, Nipaporn ; Tangnorawich, Benchamaporn ; Na-Bangchang, Kesara ; Boonprasert, Kanyarat ; Tasanarong, Adis ; Saeheng, Teerachat ; Hanwattanakul, Akkaracha ; Pechyen, Chiravoot</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c285t-4d8a83b68a7abb698b076845c43ab9c62a7685c823a5a9612459910e789490a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ponsanti, Khanittha</creatorcontrib><creatorcontrib>Ngernyuang, Nipaporn</creatorcontrib><creatorcontrib>Tangnorawich, Benchamaporn</creatorcontrib><creatorcontrib>Na-Bangchang, Kesara</creatorcontrib><creatorcontrib>Boonprasert, Kanyarat</creatorcontrib><creatorcontrib>Tasanarong, Adis</creatorcontrib><creatorcontrib>Saeheng, Teerachat</creatorcontrib><creatorcontrib>Hanwattanakul, Akkaracha</creatorcontrib><creatorcontrib>Pechyen, Chiravoot</creatorcontrib><collection>IOP Publishing Free Content</collection><collection>IOPscience (Open Access)</collection><collection>CrossRef</collection><jtitle>Journal of the Electrochemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ponsanti, Khanittha</au><au>Ngernyuang, Nipaporn</au><au>Tangnorawich, Benchamaporn</au><au>Na-Bangchang, Kesara</au><au>Boonprasert, Kanyarat</au><au>Tasanarong, Adis</au><au>Saeheng, Teerachat</au><au>Hanwattanakul, Akkaracha</au><au>Pechyen, Chiravoot</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Novel Electrochemical-Biosensor Microchip Based on MWCNTs/AuNPs for Detection of Glycated Hemoglobin (HbA1c) in Diabetes Patients</atitle><jtitle>Journal of the Electrochemical Society</jtitle><stitle>JES</stitle><addtitle>J. Electrochem. Soc</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>169</volume><issue>3</issue><spage>37520</spage><pages>37520-</pages><issn>0013-4651</issn><eissn>1945-7111</eissn><coden>JESOAN</coden><abstract>This study reports an electrochemical sensor based on multiwalled carbon nanotubes/gold nanoparticles (MWCNTs/AuNPs) for detection of total hemoglobin (Hb) and glycated hemoglobin (HbA1c) in blood samples. Measurement of glycated hemoglobin percentage (%HbA1c) is crucial to the monitoring of glycemia in diabetes patients. The %HbA1c, which refers to the concentration ratio of HbA1c to total hemoglobin (Hb), has been widely used for accurate determination of stage-wise diabetes. The gold nanoparticles (AuNPs) used in the sensor were synthesized using a biological method employing passion fruit peel extracts. The resulting AuNPs are spherical with diameter approximately 18 nm, and these can be mixed with MWCNTs in various ratios to form MWCNTs/AuNPs composites. TEM imaging indicates that gold nanoparticles decorate the surface of the MWCNTs. Coating of a screen-printed carbon electrode (SPCE) with MWCNTs/AuNPs affords the novel MWCNTs/AuNPs/SPCE electrode, which exhibits a linear response over a 0.186–2.044 g dl
−1
HbA1c concentration range, with the correlation value of 0.96. The electrode can reliably be utilized for detection of total Hb and HbA1c in blood samples, which highlights its promise as a reliable approach for sensitive point-of-care testing (POCT) of HbA1c in diabetes patients.</abstract><pub>IOP Publishing</pub><doi>10.1149/1945-7111/ac5c0a</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-6034-6597</orcidid><oa>free_for_read</oa></addata></record> |
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| title | A Novel Electrochemical-Biosensor Microchip Based on MWCNTs/AuNPs for Detection of Glycated Hemoglobin (HbA1c) in Diabetes Patients |
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