Dual Modulation of IL-6 Pathway by Flavonoid Metal Complex as Immune Boosters for SARS-CoV-2 Therapy

Dual Modulation of IL-6 Pathway by Flavonoid Metal Complex as Immune Boosters for SARS-CoV-2 Therapy

It is observed that Cytokine Release Syndrome (CRS) is one of the major causes of the death of several COVID-19 patients. Though several cytokines are involved in CRS, IL-6 modulation plays a major role. We aim to develop new flavonoid metal complexes as immune boosters targeting IL-6 for SARS-CoV-2...

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Veröffentlicht in:ECS transactions 2022-04, Vol.107 (1), p.9771-9779
Hauptverfasser: Krishna Swaroop, Akey, M, Esakkimuthukumar, S.K, Patnaik, P, Vasanth, M.R, Jeyaprakash, N, Jawahar, S, Jubie
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container_end_page 9779
container_issue 1
container_start_page 9771
container_title ECS transactions
container_volume 107
creator Krishna Swaroop, Akey
M, Esakkimuthukumar
S.K, Patnaik
P, Vasanth
M.R, Jeyaprakash
N, Jawahar
S, Jubie
description It is observed that Cytokine Release Syndrome (CRS) is one of the major causes of the death of several COVID-19 patients. Though several cytokines are involved in CRS, IL-6 modulation plays a major role. We aim to develop new flavonoid metal complexes as immune boosters targeting IL-6 for SARS-CoV-2 treatment. To find potential flavonoids, PyRx 0.9 tool has been used to dock 152 secondary plant metabolites against IL-6 (PDB ID: 1ALU). The top scorer flavonoid (quercetin) was made into quercetin zinc ascorbic acid metal complex (QM-1). The in-vitro hemolytic research revealed a modest hemolytic effect in the QM1 metal complex. To control the IL-6 inhibitory potential, the QM1 complex was screened for cytotoxicity in cell lines MCF-7 which predominantly expresses the IL-6 level. The cytotoxic effects of the QM1 complex were considered relative to the marketable Nutridac formulation. The complex quercetin-zinc-ascorbic acid (QM1) significantly affected MCF-7 cells in concentrations 48.54 μg/mL, respectively.
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title Dual Modulation of IL-6 Pathway by Flavonoid Metal Complex as Immune Boosters for SARS-CoV-2 Therapy
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