18 F-NaF PET/MRI for Detection of Carotid Atheroma in Acute Neurovascular Syndrome
Background MRI and fluorine 18-labeled sodium fluoride ( F-NaF) PET can be used to identify features of plaque instability, rupture, and disease activity, but large studies have not been performed. Purpose To evaluate the association between F-NaF activity and culprit carotid plaque in acute neurova...
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| Veröffentlicht in: | Radiology 2022-10, Vol.305 (1), p.137-148 |
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| creator | Kaczynski, Jakub Sellers, Stephanie Seidman, Michael A Syed, Maaz Dennis, Martin Mcnaught, Gillian Jansen, Maurits Semple, Scott I Alcaide-Corral, Carlos Tavares, Adriana A S MacGillivray, Thomas Debono, Samuel Forsythe, Rachael Tambyraja, Andrew Slomka, Piotr J Leipsic, Jonathon Dweck, Marc R Whiteley, William Wardlaw, Joanna van Beek, Edwin J R Newby, David E Williams, Michelle C |
| description | Background MRI and fluorine 18-labeled sodium fluoride (
F-NaF) PET can be used to identify features of plaque instability, rupture, and disease activity, but large studies have not been performed. Purpose To evaluate the association between
F-NaF activity and culprit carotid plaque in acute neurovascular syndrome. Materials and Methods In this prospective observational cohort study (October 2017 to January 2020), participants underwent
F-NaF PET/MRI. An experienced clinician determined the culprit carotid artery based on symptoms and record review.
F-NaF uptake was quantified using standardized uptake values and tissue-to-background ratios. Statistical significance was assessed with the Welch, χ
, Wilcoxon, or Fisher test. Multivariable models were used to evaluate the relationship between the imaging markers and the culprit versus nonculprit vessel. Results A total of 110 participants were evaluated (mean age, 68 years ± 10 [SD]; 70 men and 40 women). Of the 110, 34 (32%) had prior cerebrovascular disease, and 26 (24%) presented with amaurosis fugax, 54 (49%) with transient ischemic attack, and 30 (27%) with stroke. Compared with nonculprit carotids, culprit carotids had greater stenoses (≥50% stenosis: 30% vs 15% [
= .02]; ≥70% stenosis: 25% vs 4.5% [
< .001]) and had increased prevalence of MRI-derived adverse plaque features, including intraplaque hemorrhage (42% vs 23%;
= .004), necrotic core (36% vs 18%;
= .004), thrombus (7.3% vs 0%;
= .01), ulceration (18% vs 3.6%;
= .001), and higher
F-NaF uptake (maximum tissue-to-background ratio, 1.38 [IQR, 1.12-1.82] vs 1.26 [IQR, 0.99-1.66], respectively;
= .04). Higher
F-NaF uptake was positively associated with necrosis, intraplaque hemorrhage, ulceration, and calcification and inversely associated with fibrosis (
= .04 to
< .001). In multivariable analysis, carotid stenosis at or over 70% (odds ratio, 5.72 [95% CI: 2.2, 18]) and MRI-derived adverse plaque characteristics (odds ratio, 2.16 [95% CI: 1.2, 3.9]) were both associated with the culprit versus nonculprit carotid vessel. Conclusion Fluorine 18-labeled sodium fluoride PET/MRI characteristics were associated with the culprit carotid vessel in study participants with acute neurovascular syndrome. Clinical trial registration no. NCT03215550 and NCT03215563 © RSNA, 2022 |
| doi_str_mv | 10.1148/radiol.212283 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1148_radiol_212283</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>35670715</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1055-c30bcb18652b28acebab5ed49a6e46a080b6fdb07293f513f2ca3eb4de708d233</originalsourceid><addsrcrecordid>eNo90M1OAjEUhuHGaATRpVvTGyj0tNOZsiQISoJoENeT_pzGMUBJZ4aEuxcz6uoszptv8RByD3wIkOlRMr6K26EAIbS8IH1QomAgQV2SPudSMp3BuEdu6vqLc8iULq5JT6q84AWoPlmDpnO2MnP6NtuMXtYLGmKij9iga6q4pzHQqUmxqTydNJ-Y4s7Qak8nrm2QrrBN8Whq125Nou-nvT__8ZZcBbOt8e73DsjHfLaZPrPl69NiOlkyB1wp5iS3zoLOlbBCG4fWWIU-G5scs9xwzW0evOWFGMugQAbhjESbeSy49kLKAWHdrkuxrhOG8pCqnUmnEnj5Y1N2NmVnc-4fuv7Q2h36__oPQ34DKttfmg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>18 F-NaF PET/MRI for Detection of Carotid Atheroma in Acute Neurovascular Syndrome</title><source>MEDLINE</source><source>Radiological Society of North America</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Kaczynski, Jakub ; Sellers, Stephanie ; Seidman, Michael A ; Syed, Maaz ; Dennis, Martin ; Mcnaught, Gillian ; Jansen, Maurits ; Semple, Scott I ; Alcaide-Corral, Carlos ; Tavares, Adriana A S ; MacGillivray, Thomas ; Debono, Samuel ; Forsythe, Rachael ; Tambyraja, Andrew ; Slomka, Piotr J ; Leipsic, Jonathon ; Dweck, Marc R ; Whiteley, William ; Wardlaw, Joanna ; van Beek, Edwin J R ; Newby, David E ; Williams, Michelle C</creator><creatorcontrib>Kaczynski, Jakub ; Sellers, Stephanie ; Seidman, Michael A ; Syed, Maaz ; Dennis, Martin ; Mcnaught, Gillian ; Jansen, Maurits ; Semple, Scott I ; Alcaide-Corral, Carlos ; Tavares, Adriana A S ; MacGillivray, Thomas ; Debono, Samuel ; Forsythe, Rachael ; Tambyraja, Andrew ; Slomka, Piotr J ; Leipsic, Jonathon ; Dweck, Marc R ; Whiteley, William ; Wardlaw, Joanna ; van Beek, Edwin J R ; Newby, David E ; Williams, Michelle C</creatorcontrib><description>Background MRI and fluorine 18-labeled sodium fluoride (
F-NaF) PET can be used to identify features of plaque instability, rupture, and disease activity, but large studies have not been performed. Purpose To evaluate the association between
F-NaF activity and culprit carotid plaque in acute neurovascular syndrome. Materials and Methods In this prospective observational cohort study (October 2017 to January 2020), participants underwent
F-NaF PET/MRI. An experienced clinician determined the culprit carotid artery based on symptoms and record review.
F-NaF uptake was quantified using standardized uptake values and tissue-to-background ratios. Statistical significance was assessed with the Welch, χ
, Wilcoxon, or Fisher test. Multivariable models were used to evaluate the relationship between the imaging markers and the culprit versus nonculprit vessel. Results A total of 110 participants were evaluated (mean age, 68 years ± 10 [SD]; 70 men and 40 women). Of the 110, 34 (32%) had prior cerebrovascular disease, and 26 (24%) presented with amaurosis fugax, 54 (49%) with transient ischemic attack, and 30 (27%) with stroke. Compared with nonculprit carotids, culprit carotids had greater stenoses (≥50% stenosis: 30% vs 15% [
= .02]; ≥70% stenosis: 25% vs 4.5% [
< .001]) and had increased prevalence of MRI-derived adverse plaque features, including intraplaque hemorrhage (42% vs 23%;
= .004), necrotic core (36% vs 18%;
= .004), thrombus (7.3% vs 0%;
= .01), ulceration (18% vs 3.6%;
= .001), and higher
F-NaF uptake (maximum tissue-to-background ratio, 1.38 [IQR, 1.12-1.82] vs 1.26 [IQR, 0.99-1.66], respectively;
= .04). Higher
F-NaF uptake was positively associated with necrosis, intraplaque hemorrhage, ulceration, and calcification and inversely associated with fibrosis (
= .04 to
< .001). In multivariable analysis, carotid stenosis at or over 70% (odds ratio, 5.72 [95% CI: 2.2, 18]) and MRI-derived adverse plaque characteristics (odds ratio, 2.16 [95% CI: 1.2, 3.9]) were both associated with the culprit versus nonculprit carotid vessel. Conclusion Fluorine 18-labeled sodium fluoride PET/MRI characteristics were associated with the culprit carotid vessel in study participants with acute neurovascular syndrome. Clinical trial registration no. NCT03215550 and NCT03215563 © RSNA, 2022</description><identifier>ISSN: 0033-8419</identifier><identifier>EISSN: 1527-1315</identifier><identifier>DOI: 10.1148/radiol.212283</identifier><identifier>PMID: 35670715</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Carotid Arteries ; Constriction, Pathologic ; Female ; Fluorine ; Fluorine Radioisotopes ; Humans ; Magnetic Resonance Imaging ; Male ; Plaque, Atherosclerotic - complications ; Plaque, Atherosclerotic - diagnostic imaging ; Positron-Emission Tomography - methods ; Prospective Studies ; Sodium Fluoride</subject><ispartof>Radiology, 2022-10, Vol.305 (1), p.137-148</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1055-c30bcb18652b28acebab5ed49a6e46a080b6fdb07293f513f2ca3eb4de708d233</citedby><cites>FETCH-LOGICAL-c1055-c30bcb18652b28acebab5ed49a6e46a080b6fdb07293f513f2ca3eb4de708d233</cites><orcidid>0000-0001-7971-4628 ; 0000-0002-7834-8766 ; 0000-0003-1148-8972 ; 0000-0002-9812-6642 ; 0000-0002-9393-6291 ; 0000-0002-3311-9599 ; 0000-0002-9594-827X ; 0000-0002-3002-0649 ; 0000-0001-5120-0086 ; 0000-0002-6133-8334 ; 0000-0001-7505-9144 ; 0000-0001-9847-5917 ; 0000-0002-7077-0188 ; 0000-0002-3005-6860 ; 0000-0002-4008-7564 ; 0000-0002-6110-938X ; 0000-0003-3556-2428 ; 0000-0002-2777-5071 ; 0000-0002-3539-5730</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4016,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35670715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaczynski, Jakub</creatorcontrib><creatorcontrib>Sellers, Stephanie</creatorcontrib><creatorcontrib>Seidman, Michael A</creatorcontrib><creatorcontrib>Syed, Maaz</creatorcontrib><creatorcontrib>Dennis, Martin</creatorcontrib><creatorcontrib>Mcnaught, Gillian</creatorcontrib><creatorcontrib>Jansen, Maurits</creatorcontrib><creatorcontrib>Semple, Scott I</creatorcontrib><creatorcontrib>Alcaide-Corral, Carlos</creatorcontrib><creatorcontrib>Tavares, Adriana A S</creatorcontrib><creatorcontrib>MacGillivray, Thomas</creatorcontrib><creatorcontrib>Debono, Samuel</creatorcontrib><creatorcontrib>Forsythe, Rachael</creatorcontrib><creatorcontrib>Tambyraja, Andrew</creatorcontrib><creatorcontrib>Slomka, Piotr J</creatorcontrib><creatorcontrib>Leipsic, Jonathon</creatorcontrib><creatorcontrib>Dweck, Marc R</creatorcontrib><creatorcontrib>Whiteley, William</creatorcontrib><creatorcontrib>Wardlaw, Joanna</creatorcontrib><creatorcontrib>van Beek, Edwin J R</creatorcontrib><creatorcontrib>Newby, David E</creatorcontrib><creatorcontrib>Williams, Michelle C</creatorcontrib><title>18 F-NaF PET/MRI for Detection of Carotid Atheroma in Acute Neurovascular Syndrome</title><title>Radiology</title><addtitle>Radiology</addtitle><description>Background MRI and fluorine 18-labeled sodium fluoride (
F-NaF) PET can be used to identify features of plaque instability, rupture, and disease activity, but large studies have not been performed. Purpose To evaluate the association between
F-NaF activity and culprit carotid plaque in acute neurovascular syndrome. Materials and Methods In this prospective observational cohort study (October 2017 to January 2020), participants underwent
F-NaF PET/MRI. An experienced clinician determined the culprit carotid artery based on symptoms and record review.
F-NaF uptake was quantified using standardized uptake values and tissue-to-background ratios. Statistical significance was assessed with the Welch, χ
, Wilcoxon, or Fisher test. Multivariable models were used to evaluate the relationship between the imaging markers and the culprit versus nonculprit vessel. Results A total of 110 participants were evaluated (mean age, 68 years ± 10 [SD]; 70 men and 40 women). Of the 110, 34 (32%) had prior cerebrovascular disease, and 26 (24%) presented with amaurosis fugax, 54 (49%) with transient ischemic attack, and 30 (27%) with stroke. Compared with nonculprit carotids, culprit carotids had greater stenoses (≥50% stenosis: 30% vs 15% [
= .02]; ≥70% stenosis: 25% vs 4.5% [
< .001]) and had increased prevalence of MRI-derived adverse plaque features, including intraplaque hemorrhage (42% vs 23%;
= .004), necrotic core (36% vs 18%;
= .004), thrombus (7.3% vs 0%;
= .01), ulceration (18% vs 3.6%;
= .001), and higher
F-NaF uptake (maximum tissue-to-background ratio, 1.38 [IQR, 1.12-1.82] vs 1.26 [IQR, 0.99-1.66], respectively;
= .04). Higher
F-NaF uptake was positively associated with necrosis, intraplaque hemorrhage, ulceration, and calcification and inversely associated with fibrosis (
= .04 to
< .001). In multivariable analysis, carotid stenosis at or over 70% (odds ratio, 5.72 [95% CI: 2.2, 18]) and MRI-derived adverse plaque characteristics (odds ratio, 2.16 [95% CI: 1.2, 3.9]) were both associated with the culprit versus nonculprit carotid vessel. Conclusion Fluorine 18-labeled sodium fluoride PET/MRI characteristics were associated with the culprit carotid vessel in study participants with acute neurovascular syndrome. Clinical trial registration no. NCT03215550 and NCT03215563 © RSNA, 2022</description><subject>Aged</subject><subject>Carotid Arteries</subject><subject>Constriction, Pathologic</subject><subject>Female</subject><subject>Fluorine</subject><subject>Fluorine Radioisotopes</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Plaque, Atherosclerotic - complications</subject><subject>Plaque, Atherosclerotic - diagnostic imaging</subject><subject>Positron-Emission Tomography - methods</subject><subject>Prospective Studies</subject><subject>Sodium Fluoride</subject><issn>0033-8419</issn><issn>1527-1315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90M1OAjEUhuHGaATRpVvTGyj0tNOZsiQISoJoENeT_pzGMUBJZ4aEuxcz6uoszptv8RByD3wIkOlRMr6K26EAIbS8IH1QomAgQV2SPudSMp3BuEdu6vqLc8iULq5JT6q84AWoPlmDpnO2MnP6NtuMXtYLGmKij9iga6q4pzHQqUmxqTydNJ-Y4s7Qak8nrm2QrrBN8Whq125Nou-nvT__8ZZcBbOt8e73DsjHfLaZPrPl69NiOlkyB1wp5iS3zoLOlbBCG4fWWIU-G5scs9xwzW0evOWFGMugQAbhjESbeSy49kLKAWHdrkuxrhOG8pCqnUmnEnj5Y1N2NmVnc-4fuv7Q2h36__oPQ34DKttfmg</recordid><startdate>202210</startdate><enddate>202210</enddate><creator>Kaczynski, Jakub</creator><creator>Sellers, Stephanie</creator><creator>Seidman, Michael A</creator><creator>Syed, Maaz</creator><creator>Dennis, Martin</creator><creator>Mcnaught, Gillian</creator><creator>Jansen, Maurits</creator><creator>Semple, Scott I</creator><creator>Alcaide-Corral, Carlos</creator><creator>Tavares, Adriana A S</creator><creator>MacGillivray, Thomas</creator><creator>Debono, Samuel</creator><creator>Forsythe, Rachael</creator><creator>Tambyraja, Andrew</creator><creator>Slomka, Piotr J</creator><creator>Leipsic, Jonathon</creator><creator>Dweck, Marc R</creator><creator>Whiteley, William</creator><creator>Wardlaw, Joanna</creator><creator>van Beek, Edwin J R</creator><creator>Newby, David E</creator><creator>Williams, Michelle C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-7971-4628</orcidid><orcidid>https://orcid.org/0000-0002-7834-8766</orcidid><orcidid>https://orcid.org/0000-0003-1148-8972</orcidid><orcidid>https://orcid.org/0000-0002-9812-6642</orcidid><orcidid>https://orcid.org/0000-0002-9393-6291</orcidid><orcidid>https://orcid.org/0000-0002-3311-9599</orcidid><orcidid>https://orcid.org/0000-0002-9594-827X</orcidid><orcidid>https://orcid.org/0000-0002-3002-0649</orcidid><orcidid>https://orcid.org/0000-0001-5120-0086</orcidid><orcidid>https://orcid.org/0000-0002-6133-8334</orcidid><orcidid>https://orcid.org/0000-0001-7505-9144</orcidid><orcidid>https://orcid.org/0000-0001-9847-5917</orcidid><orcidid>https://orcid.org/0000-0002-7077-0188</orcidid><orcidid>https://orcid.org/0000-0002-3005-6860</orcidid><orcidid>https://orcid.org/0000-0002-4008-7564</orcidid><orcidid>https://orcid.org/0000-0002-6110-938X</orcidid><orcidid>https://orcid.org/0000-0003-3556-2428</orcidid><orcidid>https://orcid.org/0000-0002-2777-5071</orcidid><orcidid>https://orcid.org/0000-0002-3539-5730</orcidid></search><sort><creationdate>202210</creationdate><title>18 F-NaF PET/MRI for Detection of Carotid Atheroma in Acute Neurovascular Syndrome</title><author>Kaczynski, Jakub ; Sellers, Stephanie ; Seidman, Michael A ; Syed, Maaz ; Dennis, Martin ; Mcnaught, Gillian ; Jansen, Maurits ; Semple, Scott I ; Alcaide-Corral, Carlos ; Tavares, Adriana A S ; MacGillivray, Thomas ; Debono, Samuel ; Forsythe, Rachael ; Tambyraja, Andrew ; Slomka, Piotr J ; Leipsic, Jonathon ; Dweck, Marc R ; Whiteley, William ; Wardlaw, Joanna ; van Beek, Edwin J R ; Newby, David E ; Williams, Michelle C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1055-c30bcb18652b28acebab5ed49a6e46a080b6fdb07293f513f2ca3eb4de708d233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged</topic><topic>Carotid Arteries</topic><topic>Constriction, Pathologic</topic><topic>Female</topic><topic>Fluorine</topic><topic>Fluorine Radioisotopes</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Plaque, Atherosclerotic - complications</topic><topic>Plaque, Atherosclerotic - diagnostic imaging</topic><topic>Positron-Emission Tomography - methods</topic><topic>Prospective Studies</topic><topic>Sodium Fluoride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaczynski, Jakub</creatorcontrib><creatorcontrib>Sellers, Stephanie</creatorcontrib><creatorcontrib>Seidman, Michael A</creatorcontrib><creatorcontrib>Syed, Maaz</creatorcontrib><creatorcontrib>Dennis, Martin</creatorcontrib><creatorcontrib>Mcnaught, Gillian</creatorcontrib><creatorcontrib>Jansen, Maurits</creatorcontrib><creatorcontrib>Semple, Scott I</creatorcontrib><creatorcontrib>Alcaide-Corral, Carlos</creatorcontrib><creatorcontrib>Tavares, Adriana A S</creatorcontrib><creatorcontrib>MacGillivray, Thomas</creatorcontrib><creatorcontrib>Debono, Samuel</creatorcontrib><creatorcontrib>Forsythe, Rachael</creatorcontrib><creatorcontrib>Tambyraja, Andrew</creatorcontrib><creatorcontrib>Slomka, Piotr J</creatorcontrib><creatorcontrib>Leipsic, Jonathon</creatorcontrib><creatorcontrib>Dweck, Marc R</creatorcontrib><creatorcontrib>Whiteley, William</creatorcontrib><creatorcontrib>Wardlaw, Joanna</creatorcontrib><creatorcontrib>van Beek, Edwin J R</creatorcontrib><creatorcontrib>Newby, David E</creatorcontrib><creatorcontrib>Williams, Michelle C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaczynski, Jakub</au><au>Sellers, Stephanie</au><au>Seidman, Michael A</au><au>Syed, Maaz</au><au>Dennis, Martin</au><au>Mcnaught, Gillian</au><au>Jansen, Maurits</au><au>Semple, Scott I</au><au>Alcaide-Corral, Carlos</au><au>Tavares, Adriana A S</au><au>MacGillivray, Thomas</au><au>Debono, Samuel</au><au>Forsythe, Rachael</au><au>Tambyraja, Andrew</au><au>Slomka, Piotr J</au><au>Leipsic, Jonathon</au><au>Dweck, Marc R</au><au>Whiteley, William</au><au>Wardlaw, Joanna</au><au>van Beek, Edwin J R</au><au>Newby, David E</au><au>Williams, Michelle C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>18 F-NaF PET/MRI for Detection of Carotid Atheroma in Acute Neurovascular Syndrome</atitle><jtitle>Radiology</jtitle><addtitle>Radiology</addtitle><date>2022-10</date><risdate>2022</risdate><volume>305</volume><issue>1</issue><spage>137</spage><epage>148</epage><pages>137-148</pages><issn>0033-8419</issn><eissn>1527-1315</eissn><abstract>Background MRI and fluorine 18-labeled sodium fluoride (
F-NaF) PET can be used to identify features of plaque instability, rupture, and disease activity, but large studies have not been performed. Purpose To evaluate the association between
F-NaF activity and culprit carotid plaque in acute neurovascular syndrome. Materials and Methods In this prospective observational cohort study (October 2017 to January 2020), participants underwent
F-NaF PET/MRI. An experienced clinician determined the culprit carotid artery based on symptoms and record review.
F-NaF uptake was quantified using standardized uptake values and tissue-to-background ratios. Statistical significance was assessed with the Welch, χ
, Wilcoxon, or Fisher test. Multivariable models were used to evaluate the relationship between the imaging markers and the culprit versus nonculprit vessel. Results A total of 110 participants were evaluated (mean age, 68 years ± 10 [SD]; 70 men and 40 women). Of the 110, 34 (32%) had prior cerebrovascular disease, and 26 (24%) presented with amaurosis fugax, 54 (49%) with transient ischemic attack, and 30 (27%) with stroke. Compared with nonculprit carotids, culprit carotids had greater stenoses (≥50% stenosis: 30% vs 15% [
= .02]; ≥70% stenosis: 25% vs 4.5% [
< .001]) and had increased prevalence of MRI-derived adverse plaque features, including intraplaque hemorrhage (42% vs 23%;
= .004), necrotic core (36% vs 18%;
= .004), thrombus (7.3% vs 0%;
= .01), ulceration (18% vs 3.6%;
= .001), and higher
F-NaF uptake (maximum tissue-to-background ratio, 1.38 [IQR, 1.12-1.82] vs 1.26 [IQR, 0.99-1.66], respectively;
= .04). Higher
F-NaF uptake was positively associated with necrosis, intraplaque hemorrhage, ulceration, and calcification and inversely associated with fibrosis (
= .04 to
< .001). In multivariable analysis, carotid stenosis at or over 70% (odds ratio, 5.72 [95% CI: 2.2, 18]) and MRI-derived adverse plaque characteristics (odds ratio, 2.16 [95% CI: 1.2, 3.9]) were both associated with the culprit versus nonculprit carotid vessel. Conclusion Fluorine 18-labeled sodium fluoride PET/MRI characteristics were associated with the culprit carotid vessel in study participants with acute neurovascular syndrome. Clinical trial registration no. NCT03215550 and NCT03215563 © RSNA, 2022</abstract><cop>United States</cop><pmid>35670715</pmid><doi>10.1148/radiol.212283</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-7971-4628</orcidid><orcidid>https://orcid.org/0000-0002-7834-8766</orcidid><orcidid>https://orcid.org/0000-0003-1148-8972</orcidid><orcidid>https://orcid.org/0000-0002-9812-6642</orcidid><orcidid>https://orcid.org/0000-0002-9393-6291</orcidid><orcidid>https://orcid.org/0000-0002-3311-9599</orcidid><orcidid>https://orcid.org/0000-0002-9594-827X</orcidid><orcidid>https://orcid.org/0000-0002-3002-0649</orcidid><orcidid>https://orcid.org/0000-0001-5120-0086</orcidid><orcidid>https://orcid.org/0000-0002-6133-8334</orcidid><orcidid>https://orcid.org/0000-0001-7505-9144</orcidid><orcidid>https://orcid.org/0000-0001-9847-5917</orcidid><orcidid>https://orcid.org/0000-0002-7077-0188</orcidid><orcidid>https://orcid.org/0000-0002-3005-6860</orcidid><orcidid>https://orcid.org/0000-0002-4008-7564</orcidid><orcidid>https://orcid.org/0000-0002-6110-938X</orcidid><orcidid>https://orcid.org/0000-0003-3556-2428</orcidid><orcidid>https://orcid.org/0000-0002-2777-5071</orcidid><orcidid>https://orcid.org/0000-0002-3539-5730</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-8419 |
| ispartof | Radiology, 2022-10, Vol.305 (1), p.137-148 |
| issn | 0033-8419 1527-1315 |
| language | eng |
| recordid | cdi_crossref_primary_10_1148_radiol_212283 |
| source | MEDLINE; Radiological Society of North America; EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Carotid Arteries Constriction, Pathologic Female Fluorine Fluorine Radioisotopes Humans Magnetic Resonance Imaging Male Plaque, Atherosclerotic - complications Plaque, Atherosclerotic - diagnostic imaging Positron-Emission Tomography - methods Prospective Studies Sodium Fluoride |
| title | 18 F-NaF PET/MRI for Detection of Carotid Atheroma in Acute Neurovascular Syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T11%3A41%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=18%20F-NaF%20PET/MRI%20for%20Detection%20of%20Carotid%20Atheroma%20in%20Acute%20Neurovascular%20Syndrome&rft.jtitle=Radiology&rft.au=Kaczynski,%20Jakub&rft.date=2022-10&rft.volume=305&rft.issue=1&rft.spage=137&rft.epage=148&rft.pages=137-148&rft.issn=0033-8419&rft.eissn=1527-1315&rft_id=info:doi/10.1148/radiol.212283&rft_dat=%3Cpubmed_cross%3E35670715%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/35670715&rfr_iscdi=true |