LI-RADS Version 2017 versus Version 2018: Diagnosis of Hepatocellular Carcinoma on Gadoxetate Disodium-enhanced MRI
Background Few studies have reported on the diagnostic performance of Liver Imaging Reporting and Data System (LI-RADS) LR-5 or LR-5 V in the diagnosis of hepatocellular carcinoma (HCC) using MRI with gadoxetate disodium. Purpose To determine the diagnostic performance of LI-RADS version 2018 (herea...
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| Veröffentlicht in: | Radiology 2019-09, Vol.292 (3), p.655-663 |
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| creator | Lee, Sang Min Lee, Jeong Min Ahn, Su Joa Kang, Hyo-Jin Yang, Hyun Kyung Yoon, Jeong Hee |
| description | Background Few studies have reported on the diagnostic performance of Liver Imaging Reporting and Data System (LI-RADS) LR-5 or LR-5 V in the diagnosis of hepatocellular carcinoma (HCC) using MRI with gadoxetate disodium. Purpose To determine the diagnostic performance of LI-RADS version 2018 (hereafter, v2018) on gadoxetate disodium-enhanced MRI in comparison with LI-RADS version 2017 (hereafter, v2017) for the diagnosis of HCC in patients with cirrhosis or chronic hepatitis B viral infection or at high risk for HCC. Materials and Methods This retrospective study between January 2013 and October 2015 evaluated consecutive patients at high risk for HCC who had at least one observation of 10 mm or greater on gadoxetate disodium-enhanced MRI and no history of previous treatment for hepatic lesions. MRI features were reviewed by three radiologists. Observations were categorized according to LI-RADS v2018 and LI-RADS v2017. Per-observation sensitivity and specificity of LR-5 using LI-RADS v2017 and v2018 were compared using generalized estimating equation models. Results A total of 422 observations, including 234 HCCs confirmed by results of pathologic examination in 387 patients (305 men and 82 women; mean age ± standard deviation, 59 years ± 10), were included. In all observations, LI-RADS v2018 provided higher sensitivity than LI-RADS v2017 (81% [189 of 234] vs 68% [160 of 234], respectively;
< .001). In small observations (10-19 mm), LI-RADS v2018 yielded much higher sensitivity than LI-RADS v2017 (76% [34 of 45] vs 11% [five of 45], respectively;
< .001) with relatively little impairment of specificity (94% [121 of 128] vs 99% [127 of 128], respectively;
= .013). Conclusion Updated LR-5 criteria of Liver Imaging Reporting and Data System (LI-RADS) version 2018 on gadoxetate disodium-enhanced MRI can improve sensitivity in the diagnosis of small hepatocellular carcinomas (10-19 mm) with only slight impairment in specificity compared with the criteria of LI-RADS version 2017. © RSNA, 2019 |
| doi_str_mv | 10.1148/radiol.2019182867 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1148_radiol_2019182867</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>31310175</sourcerecordid><originalsourceid>FETCH-LOGICAL-c198t-8ede3bddd980efa6950d5837dac8f1e70a6ba9e12ccdc118e56468d65de9bbfb3</originalsourceid><addsrcrecordid>eNpNkMtOwzAQRS0EoqXwAWyQf8DFE8eJw65qoa1UhFQe28ixJxCUxJWdIPh7gsprNbqje-7iEHIOfAoQq0uvbeXqacQhAxWpJD0gY5BRykCAPCRjzoVgKoZsRE5CeOUcYqnSYzISQ4FDKsckbNZsO1vc0yf0oXItHcZS-jaEPvz_qSu6qPRz60IVqCvpCne6cwbruq-1p3PtTdW6RtOhvtTWvWOnOxyY4GzVNwzbF90atPR2uz4lR6WuA5593wl5vLl-mK_Y5m65ns82zECmOqbQoiistZniWOokk9xKJVKrjSoBU66TQmcIkTHWACiUSZwom0iLWVGUhZgQ2O8a70LwWOY7XzXaf-TA8y-B-V5g_idwYC72zK4vGrS_xI8x8QlQvW3x</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>LI-RADS Version 2017 versus Version 2018: Diagnosis of Hepatocellular Carcinoma on Gadoxetate Disodium-enhanced MRI</title><source>MEDLINE</source><source>Radiological Society of North America</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Lee, Sang Min ; Lee, Jeong Min ; Ahn, Su Joa ; Kang, Hyo-Jin ; Yang, Hyun Kyung ; Yoon, Jeong Hee</creator><creatorcontrib>Lee, Sang Min ; Lee, Jeong Min ; Ahn, Su Joa ; Kang, Hyo-Jin ; Yang, Hyun Kyung ; Yoon, Jeong Hee</creatorcontrib><description>Background Few studies have reported on the diagnostic performance of Liver Imaging Reporting and Data System (LI-RADS) LR-5 or LR-5 V in the diagnosis of hepatocellular carcinoma (HCC) using MRI with gadoxetate disodium. Purpose To determine the diagnostic performance of LI-RADS version 2018 (hereafter, v2018) on gadoxetate disodium-enhanced MRI in comparison with LI-RADS version 2017 (hereafter, v2017) for the diagnosis of HCC in patients with cirrhosis or chronic hepatitis B viral infection or at high risk for HCC. Materials and Methods This retrospective study between January 2013 and October 2015 evaluated consecutive patients at high risk for HCC who had at least one observation of 10 mm or greater on gadoxetate disodium-enhanced MRI and no history of previous treatment for hepatic lesions. MRI features were reviewed by three radiologists. Observations were categorized according to LI-RADS v2018 and LI-RADS v2017. Per-observation sensitivity and specificity of LR-5 using LI-RADS v2017 and v2018 were compared using generalized estimating equation models. Results A total of 422 observations, including 234 HCCs confirmed by results of pathologic examination in 387 patients (305 men and 82 women; mean age ± standard deviation, 59 years ± 10), were included. In all observations, LI-RADS v2018 provided higher sensitivity than LI-RADS v2017 (81% [189 of 234] vs 68% [160 of 234], respectively;
< .001). In small observations (10-19 mm), LI-RADS v2018 yielded much higher sensitivity than LI-RADS v2017 (76% [34 of 45] vs 11% [five of 45], respectively;
< .001) with relatively little impairment of specificity (94% [121 of 128] vs 99% [127 of 128], respectively;
= .013). Conclusion Updated LR-5 criteria of Liver Imaging Reporting and Data System (LI-RADS) version 2018 on gadoxetate disodium-enhanced MRI can improve sensitivity in the diagnosis of small hepatocellular carcinomas (10-19 mm) with only slight impairment in specificity compared with the criteria of LI-RADS version 2017. © RSNA, 2019</description><identifier>ISSN: 0033-8419</identifier><identifier>EISSN: 1527-1315</identifier><identifier>DOI: 10.1148/radiol.2019182867</identifier><identifier>PMID: 31310175</identifier><language>eng</language><publisher>United States</publisher><subject>Carcinoma, Hepatocellular - diagnostic imaging ; Cohort Studies ; Contrast Media ; Female ; Gadolinium DTPA ; Humans ; Image Enhancement - methods ; Liver - diagnostic imaging ; Liver Neoplasms - diagnostic imaging ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Radiology Information Systems ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity</subject><ispartof>Radiology, 2019-09, Vol.292 (3), p.655-663</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c198t-8ede3bddd980efa6950d5837dac8f1e70a6ba9e12ccdc118e56468d65de9bbfb3</citedby><cites>FETCH-LOGICAL-c198t-8ede3bddd980efa6950d5837dac8f1e70a6ba9e12ccdc118e56468d65de9bbfb3</cites><orcidid>0000-0001-7719-3849 ; 0000-0002-6771-2112 ; 0000-0002-9925-9973 ; 0000-0003-0561-8777</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4002,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31310175$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Sang Min</creatorcontrib><creatorcontrib>Lee, Jeong Min</creatorcontrib><creatorcontrib>Ahn, Su Joa</creatorcontrib><creatorcontrib>Kang, Hyo-Jin</creatorcontrib><creatorcontrib>Yang, Hyun Kyung</creatorcontrib><creatorcontrib>Yoon, Jeong Hee</creatorcontrib><title>LI-RADS Version 2017 versus Version 2018: Diagnosis of Hepatocellular Carcinoma on Gadoxetate Disodium-enhanced MRI</title><title>Radiology</title><addtitle>Radiology</addtitle><description>Background Few studies have reported on the diagnostic performance of Liver Imaging Reporting and Data System (LI-RADS) LR-5 or LR-5 V in the diagnosis of hepatocellular carcinoma (HCC) using MRI with gadoxetate disodium. Purpose To determine the diagnostic performance of LI-RADS version 2018 (hereafter, v2018) on gadoxetate disodium-enhanced MRI in comparison with LI-RADS version 2017 (hereafter, v2017) for the diagnosis of HCC in patients with cirrhosis or chronic hepatitis B viral infection or at high risk for HCC. Materials and Methods This retrospective study between January 2013 and October 2015 evaluated consecutive patients at high risk for HCC who had at least one observation of 10 mm or greater on gadoxetate disodium-enhanced MRI and no history of previous treatment for hepatic lesions. MRI features were reviewed by three radiologists. Observations were categorized according to LI-RADS v2018 and LI-RADS v2017. Per-observation sensitivity and specificity of LR-5 using LI-RADS v2017 and v2018 were compared using generalized estimating equation models. Results A total of 422 observations, including 234 HCCs confirmed by results of pathologic examination in 387 patients (305 men and 82 women; mean age ± standard deviation, 59 years ± 10), were included. In all observations, LI-RADS v2018 provided higher sensitivity than LI-RADS v2017 (81% [189 of 234] vs 68% [160 of 234], respectively;
< .001). In small observations (10-19 mm), LI-RADS v2018 yielded much higher sensitivity than LI-RADS v2017 (76% [34 of 45] vs 11% [five of 45], respectively;
< .001) with relatively little impairment of specificity (94% [121 of 128] vs 99% [127 of 128], respectively;
= .013). Conclusion Updated LR-5 criteria of Liver Imaging Reporting and Data System (LI-RADS) version 2018 on gadoxetate disodium-enhanced MRI can improve sensitivity in the diagnosis of small hepatocellular carcinomas (10-19 mm) with only slight impairment in specificity compared with the criteria of LI-RADS version 2017. © RSNA, 2019</description><subject>Carcinoma, Hepatocellular - diagnostic imaging</subject><subject>Cohort Studies</subject><subject>Contrast Media</subject><subject>Female</subject><subject>Gadolinium DTPA</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Liver - diagnostic imaging</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Radiology Information Systems</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><issn>0033-8419</issn><issn>1527-1315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtOwzAQRS0EoqXwAWyQf8DFE8eJw65qoa1UhFQe28ixJxCUxJWdIPh7gsprNbqje-7iEHIOfAoQq0uvbeXqacQhAxWpJD0gY5BRykCAPCRjzoVgKoZsRE5CeOUcYqnSYzISQ4FDKsckbNZsO1vc0yf0oXItHcZS-jaEPvz_qSu6qPRz60IVqCvpCne6cwbruq-1p3PtTdW6RtOhvtTWvWOnOxyY4GzVNwzbF90atPR2uz4lR6WuA5593wl5vLl-mK_Y5m65ns82zECmOqbQoiistZniWOokk9xKJVKrjSoBU66TQmcIkTHWACiUSZwom0iLWVGUhZgQ2O8a70LwWOY7XzXaf-TA8y-B-V5g_idwYC72zK4vGrS_xI8x8QlQvW3x</recordid><startdate>201909</startdate><enddate>201909</enddate><creator>Lee, Sang Min</creator><creator>Lee, Jeong Min</creator><creator>Ahn, Su Joa</creator><creator>Kang, Hyo-Jin</creator><creator>Yang, Hyun Kyung</creator><creator>Yoon, Jeong Hee</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-7719-3849</orcidid><orcidid>https://orcid.org/0000-0002-6771-2112</orcidid><orcidid>https://orcid.org/0000-0002-9925-9973</orcidid><orcidid>https://orcid.org/0000-0003-0561-8777</orcidid></search><sort><creationdate>201909</creationdate><title>LI-RADS Version 2017 versus Version 2018: Diagnosis of Hepatocellular Carcinoma on Gadoxetate Disodium-enhanced MRI</title><author>Lee, Sang Min ; Lee, Jeong Min ; Ahn, Su Joa ; Kang, Hyo-Jin ; Yang, Hyun Kyung ; Yoon, Jeong Hee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c198t-8ede3bddd980efa6950d5837dac8f1e70a6ba9e12ccdc118e56468d65de9bbfb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Carcinoma, Hepatocellular - diagnostic imaging</topic><topic>Cohort Studies</topic><topic>Contrast Media</topic><topic>Female</topic><topic>Gadolinium DTPA</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Liver - diagnostic imaging</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Radiology Information Systems</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Sang Min</creatorcontrib><creatorcontrib>Lee, Jeong Min</creatorcontrib><creatorcontrib>Ahn, Su Joa</creatorcontrib><creatorcontrib>Kang, Hyo-Jin</creatorcontrib><creatorcontrib>Yang, Hyun Kyung</creatorcontrib><creatorcontrib>Yoon, Jeong Hee</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Sang Min</au><au>Lee, Jeong Min</au><au>Ahn, Su Joa</au><au>Kang, Hyo-Jin</au><au>Yang, Hyun Kyung</au><au>Yoon, Jeong Hee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LI-RADS Version 2017 versus Version 2018: Diagnosis of Hepatocellular Carcinoma on Gadoxetate Disodium-enhanced MRI</atitle><jtitle>Radiology</jtitle><addtitle>Radiology</addtitle><date>2019-09</date><risdate>2019</risdate><volume>292</volume><issue>3</issue><spage>655</spage><epage>663</epage><pages>655-663</pages><issn>0033-8419</issn><eissn>1527-1315</eissn><abstract>Background Few studies have reported on the diagnostic performance of Liver Imaging Reporting and Data System (LI-RADS) LR-5 or LR-5 V in the diagnosis of hepatocellular carcinoma (HCC) using MRI with gadoxetate disodium. Purpose To determine the diagnostic performance of LI-RADS version 2018 (hereafter, v2018) on gadoxetate disodium-enhanced MRI in comparison with LI-RADS version 2017 (hereafter, v2017) for the diagnosis of HCC in patients with cirrhosis or chronic hepatitis B viral infection or at high risk for HCC. Materials and Methods This retrospective study between January 2013 and October 2015 evaluated consecutive patients at high risk for HCC who had at least one observation of 10 mm or greater on gadoxetate disodium-enhanced MRI and no history of previous treatment for hepatic lesions. MRI features were reviewed by three radiologists. Observations were categorized according to LI-RADS v2018 and LI-RADS v2017. Per-observation sensitivity and specificity of LR-5 using LI-RADS v2017 and v2018 were compared using generalized estimating equation models. Results A total of 422 observations, including 234 HCCs confirmed by results of pathologic examination in 387 patients (305 men and 82 women; mean age ± standard deviation, 59 years ± 10), were included. In all observations, LI-RADS v2018 provided higher sensitivity than LI-RADS v2017 (81% [189 of 234] vs 68% [160 of 234], respectively;
< .001). In small observations (10-19 mm), LI-RADS v2018 yielded much higher sensitivity than LI-RADS v2017 (76% [34 of 45] vs 11% [five of 45], respectively;
< .001) with relatively little impairment of specificity (94% [121 of 128] vs 99% [127 of 128], respectively;
= .013). Conclusion Updated LR-5 criteria of Liver Imaging Reporting and Data System (LI-RADS) version 2018 on gadoxetate disodium-enhanced MRI can improve sensitivity in the diagnosis of small hepatocellular carcinomas (10-19 mm) with only slight impairment in specificity compared with the criteria of LI-RADS version 2017. © RSNA, 2019</abstract><cop>United States</cop><pmid>31310175</pmid><doi>10.1148/radiol.2019182867</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7719-3849</orcidid><orcidid>https://orcid.org/0000-0002-6771-2112</orcidid><orcidid>https://orcid.org/0000-0002-9925-9973</orcidid><orcidid>https://orcid.org/0000-0003-0561-8777</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Radiological Society of North America; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Carcinoma, Hepatocellular - diagnostic imaging Cohort Studies Contrast Media Female Gadolinium DTPA Humans Image Enhancement - methods Liver - diagnostic imaging Liver Neoplasms - diagnostic imaging Magnetic Resonance Imaging - methods Male Middle Aged Radiology Information Systems Reproducibility of Results Retrospective Studies Sensitivity and Specificity |
| title | LI-RADS Version 2017 versus Version 2018: Diagnosis of Hepatocellular Carcinoma on Gadoxetate Disodium-enhanced MRI |
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