Three-dimensional quantification of protoporphyrin IX in photodynamic therapy using SFDI/DFT: A pilot experimental validation
Photodynamic therapy (PDT) dosimetry, including light dose, photosensitizer dose and tissue oxygen, has been a research focus in PDT. In this work, we present a three-dimensional (3D) quantification of protoporphyrin IX (PpIX) using combined spatial frequency domain imaging (SFDI) and diffuse fluore...
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| Veröffentlicht in: | Journal of innovative optical health science 2022-11, Vol.15 (6) |
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| creator | Dan, Mai Song, Weijie Liu, Meihui Zhang, Yaru Gao, Feng |
| description | Photodynamic therapy (PDT) dosimetry, including light dose, photosensitizer dose and tissue oxygen, has been a research focus in PDT. In this work, we present a three-dimensional (3D) quantification of protoporphyrin IX (PpIX) using combined spatial frequency domain imaging (SFDI) and diffuse fluorescence tomography (DFT). The SFDI maps both the distributions of tissue absorption and scattering properties at three wavelengths and accordingly provides the optical background for DFT and extracts the tissue oxygenation for assessing the therapeutic outcomes, while DFT dynamically monitors the 3D distribution of PpIX dose from measured fluorescence signals for the procedure optimization. A pilot in vivo application in tumor nude models showed that the proposed SFDI/DFT is able to dynamically trace changes in the PpIX concentration and tissue oxygen during the treatment, rendering it a potentially powerful tool for PDT to improve clinical efficacy. |
| doi_str_mv | 10.1142/S1793545822400089 |
| format | Article |
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In this work, we present a three-dimensional (3D) quantification of protoporphyrin IX (PpIX) using combined spatial frequency domain imaging (SFDI) and diffuse fluorescence tomography (DFT). The SFDI maps both the distributions of tissue absorption and scattering properties at three wavelengths and accordingly provides the optical background for DFT and extracts the tissue oxygenation for assessing the therapeutic outcomes, while DFT dynamically monitors the 3D distribution of PpIX dose from measured fluorescence signals for the procedure optimization. A pilot in vivo application in tumor nude models showed that the proposed SFDI/DFT is able to dynamically trace changes in the PpIX concentration and tissue oxygen during the treatment, rendering it a potentially powerful tool for PDT to improve clinical efficacy.</description><identifier>ISSN: 1793-5458</identifier><identifier>EISSN: 1793-7205</identifier><identifier>DOI: 10.1142/S1793545822400089</identifier><language>eng</language><publisher>Singapore: World Scientific Publishing Company</publisher><subject>diffuse fluorescence tomography ; Dosimeters ; Dosimetry ; Fluorescence ; Frequency dependence ; Optical properties ; Optimization ; Oxygen ; Oxygenation ; Photodynamic therapy ; Protoporphyrin ; Protoporphyrin IX ; spatial frequency domain imaging ; Tissues ; Tumors ; Wavelengths</subject><ispartof>Journal of innovative optical health science, 2022-11, Vol.15 (6)</ispartof><rights>2022, The Author(s)</rights><rights>2022. The Author(s). This is an Open Access article. 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| subjects | diffuse fluorescence tomography Dosimeters Dosimetry Fluorescence Frequency dependence Optical properties Optimization Oxygen Oxygenation Photodynamic therapy Protoporphyrin Protoporphyrin IX spatial frequency domain imaging Tissues Tumors Wavelengths |
| title | Three-dimensional quantification of protoporphyrin IX in photodynamic therapy using SFDI/DFT: A pilot experimental validation |
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