Structure-activity relationship study of synthetic hydrazines as ecdysone agonists in the control of spruce budworm (Choristoneurafumiferana)

Structure-activity relationship study of synthetic hydrazines as ecdysone agonists in the control of spruce budworm (Choristoneurafumiferana)

A quantitative structure-activity relationship study was performed for a number of aroylhydrazine compounds with respect to their biological activity against spruce budworm. It was found that the biological activity can be modulated by substituents on the aromatic rings. Substituents with high π val...

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Veröffentlicht in:Canadian journal of chemistry 1995-04, Vol.73 (4), p.550-557
Hauptverfasser: Mohammed-Ali, Anmar K, Chan, Tak-Hang, Thomas, Anthony W, Strunz, George M, Jewett, Brent
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Sprache:eng
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Choristoneura fumiferana
Lepidoptera
Tortricidae
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container_end_page 557
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container_title Canadian journal of chemistry
container_volume 73
creator Mohammed-Ali, Anmar K
Chan, Tak-Hang
Thomas, Anthony W
Strunz, George M
Jewett, Brent
description A quantitative structure-activity relationship study was performed for a number of aroylhydrazine compounds with respect to their biological activity against spruce budworm. It was found that the biological activity can be modulated by substituents on the aromatic rings. Substituents with high π value and small L value lead to increase in biological activity. Molecular mechanics calculations were used to explain how the active compounds may mimic the strong-binding Y region of ecdysone. Keywords: spruce budworm, ecdysone, agonist, hydrazines, quantitative structure-activity relationship.
doi_str_mv 10.1139/v95-071
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subjects Choristoneura fumiferana
Lepidoptera
Tortricidae
title Structure-activity relationship study of synthetic hydrazines as ecdysone agonists in the control of spruce budworm (Choristoneurafumiferana)
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