Shelf-life prediction from induction period calorimetric measurements on materials undergoing autocatalytic decomposition

Shelf-life prediction from induction period calorimetric measurements on materials undergoing autocatalytic decomposition

The shelf- or use-life of a material which decomposes by an autocatalytic reaction is shown to be inversely proportional to the rate of heat generation during the induction period of the degradation reaction. Calorimetric measurement of the rate of heat generation during the induction period takes o...

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Veröffentlicht in:Canadian journal of chemistry 1990-11, Vol.68 (11), p.2111-2114
Hauptverfasser: Hansen, Lee D, Eatough, Delbert J, Lewis, Edwin A, Bergstrom, Robert G, Degraft-Johnson, Damaris, Cassidy-Thompson, Karen
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container_end_page 2114
container_issue 11
container_start_page 2111
container_title Canadian journal of chemistry
container_volume 68
creator Hansen, Lee D
Eatough, Delbert J
Lewis, Edwin A
Bergstrom, Robert G
Degraft-Johnson, Damaris
Cassidy-Thompson, Karen
description The shelf- or use-life of a material which decomposes by an autocatalytic reaction is shown to be inversely proportional to the rate of heat generation during the induction period of the degradation reaction. Calorimetric measurement of the rate of heat generation during the induction period takes only a few hours. It can often be done at or very near the actual storage or use temperature of the material. Measurements on Lovastatin (2-methylbutanoic acid 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenylester) are used as an example of this application. Keywords: autocatalytic, calorimetry, oxidation, decomposition, Lovastatin, Mevacor.
doi_str_mv 10.1139/v90-321
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title Shelf-life prediction from induction period calorimetric measurements on materials undergoing autocatalytic decomposition
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