A Short Review of Biochemical Mechanisms in Iminodipropionitrile-Induced Movement Disorder
Iminodipropionitrile (IDPN) is a synthetic nitrile that produces permanent behavioral syndrome characterized by repetitive head movements, circling and back walking in rodents. Other synthetic nitriles of industrial importance such as crotonitrile and allylnitrile are also able to produce similar mo...
Gespeichert in:
| Veröffentlicht in: | Neurochemical journal 2020, Vol.14 (1), p.9-12 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 12 |
|---|---|
| container_issue | 1 |
| container_start_page | 9 |
| container_title | Neurochemical journal |
| container_volume | 14 |
| creator | Sara T. Alrashood Elrobh, Mohamed S. Alamery, Salman Odeibat, Hamza A. Khan, Haseeb A. |
| description | Iminodipropionitrile (IDPN) is a synthetic nitrile that produces permanent behavioral syndrome characterized by repetitive head movements, circling and back walking in rodents. Other synthetic nitriles of industrial importance such as crotonitrile and allylnitrile are also able to produce similar motor deficits in experimental animals. Among these nitriles, IDPN has been recognized as a prototype nitrile to be used as a positive control for behavioral testing battery. Due to the well-defined behavioral deficits and their easy quantification, IDPN-induced behavioral syndrome is a preferential animal model to test the interaction of various agents with synthetic nitriles. The mechanism of IDPN-induced dyskinesia is multifactorial. This short review focuses on the roles of neurotransmitters, oxidative stress and inflammation in the pathogenesis of IDPN-induced neurotoxicity and behavioral deficits. |
| doi_str_mv | 10.1134/S1819712420010031 |
| format | Article |
| fullrecord | <record><control><sourceid>crossref_sprin</sourceid><recordid>TN_cdi_crossref_primary_10_1134_S1819712420010031</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1134_S1819712420010031</sourcerecordid><originalsourceid>FETCH-LOGICAL-c170t-b22b4e51ac8e986228a0994e4969b9c75f114dbfbd4d458859ac4a85f756d1dc3</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMoWKs_wFv-wGomm22SY61fhRbB6sXLkk1mbUo3KclW8d_bUvEieJqX4X2G4SHkEtgVQCmuF6BAS-CCMwaMlXBEBvtVIaHkx7-Zi1NylvOKsUpKzQfkbUwXy5h6-owfHj9pbOmNj3aJnbdmTedolyb43GXqA512PkTnNylufAy-T36NxTS4rUVH5_EDOww9vfU5JofpnJy0Zp3x4mcOyev93cvksZg9PUwn41lhQbK-aDhvBFZgrEKtRpwrw7QWKPRIN9rKqgUQrmkbJ5yolKq0scKoqpXVyIGz5ZDA4a5NMeeEbb1JvjPpqwZW7-XUf-TsGH5g8q4b3jHVq7hNYffmP9A3QG9nDw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>A Short Review of Biochemical Mechanisms in Iminodipropionitrile-Induced Movement Disorder</title><source>SpringerLink Journals - AutoHoldings</source><creator>Sara T. Alrashood ; Elrobh, Mohamed S. ; Alamery, Salman ; Odeibat, Hamza A. ; Khan, Haseeb A.</creator><creatorcontrib>Sara T. Alrashood ; Elrobh, Mohamed S. ; Alamery, Salman ; Odeibat, Hamza A. ; Khan, Haseeb A.</creatorcontrib><description>Iminodipropionitrile (IDPN) is a synthetic nitrile that produces permanent behavioral syndrome characterized by repetitive head movements, circling and back walking in rodents. Other synthetic nitriles of industrial importance such as crotonitrile and allylnitrile are also able to produce similar motor deficits in experimental animals. Among these nitriles, IDPN has been recognized as a prototype nitrile to be used as a positive control for behavioral testing battery. Due to the well-defined behavioral deficits and their easy quantification, IDPN-induced behavioral syndrome is a preferential animal model to test the interaction of various agents with synthetic nitriles. The mechanism of IDPN-induced dyskinesia is multifactorial. This short review focuses on the roles of neurotransmitters, oxidative stress and inflammation in the pathogenesis of IDPN-induced neurotoxicity and behavioral deficits.</description><identifier>ISSN: 1819-7124</identifier><identifier>EISSN: 1819-7132</identifier><identifier>DOI: 10.1134/S1819712420010031</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Neurosciences ; Review Articles</subject><ispartof>Neurochemical journal, 2020, Vol.14 (1), p.9-12</ispartof><rights>Pleiades Publishing, Ltd. 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c170t-b22b4e51ac8e986228a0994e4969b9c75f114dbfbd4d458859ac4a85f756d1dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1819712420010031$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1819712420010031$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids></links><search><creatorcontrib>Sara T. Alrashood</creatorcontrib><creatorcontrib>Elrobh, Mohamed S.</creatorcontrib><creatorcontrib>Alamery, Salman</creatorcontrib><creatorcontrib>Odeibat, Hamza A.</creatorcontrib><creatorcontrib>Khan, Haseeb A.</creatorcontrib><title>A Short Review of Biochemical Mechanisms in Iminodipropionitrile-Induced Movement Disorder</title><title>Neurochemical journal</title><addtitle>Neurochem. J</addtitle><description>Iminodipropionitrile (IDPN) is a synthetic nitrile that produces permanent behavioral syndrome characterized by repetitive head movements, circling and back walking in rodents. Other synthetic nitriles of industrial importance such as crotonitrile and allylnitrile are also able to produce similar motor deficits in experimental animals. Among these nitriles, IDPN has been recognized as a prototype nitrile to be used as a positive control for behavioral testing battery. Due to the well-defined behavioral deficits and their easy quantification, IDPN-induced behavioral syndrome is a preferential animal model to test the interaction of various agents with synthetic nitriles. The mechanism of IDPN-induced dyskinesia is multifactorial. This short review focuses on the roles of neurotransmitters, oxidative stress and inflammation in the pathogenesis of IDPN-induced neurotoxicity and behavioral deficits.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Neurosciences</subject><subject>Review Articles</subject><issn>1819-7124</issn><issn>1819-7132</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMoWKs_wFv-wGomm22SY61fhRbB6sXLkk1mbUo3KclW8d_bUvEieJqX4X2G4SHkEtgVQCmuF6BAS-CCMwaMlXBEBvtVIaHkx7-Zi1NylvOKsUpKzQfkbUwXy5h6-owfHj9pbOmNj3aJnbdmTedolyb43GXqA512PkTnNylufAy-T36NxTS4rUVH5_EDOww9vfU5JofpnJy0Zp3x4mcOyev93cvksZg9PUwn41lhQbK-aDhvBFZgrEKtRpwrw7QWKPRIN9rKqgUQrmkbJ5yolKq0scKoqpXVyIGz5ZDA4a5NMeeEbb1JvjPpqwZW7-XUf-TsGH5g8q4b3jHVq7hNYffmP9A3QG9nDw</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Sara T. Alrashood</creator><creator>Elrobh, Mohamed S.</creator><creator>Alamery, Salman</creator><creator>Odeibat, Hamza A.</creator><creator>Khan, Haseeb A.</creator><general>Pleiades Publishing</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2020</creationdate><title>A Short Review of Biochemical Mechanisms in Iminodipropionitrile-Induced Movement Disorder</title><author>Sara T. Alrashood ; Elrobh, Mohamed S. ; Alamery, Salman ; Odeibat, Hamza A. ; Khan, Haseeb A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c170t-b22b4e51ac8e986228a0994e4969b9c75f114dbfbd4d458859ac4a85f756d1dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Neurosciences</topic><topic>Review Articles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sara T. Alrashood</creatorcontrib><creatorcontrib>Elrobh, Mohamed S.</creatorcontrib><creatorcontrib>Alamery, Salman</creatorcontrib><creatorcontrib>Odeibat, Hamza A.</creatorcontrib><creatorcontrib>Khan, Haseeb A.</creatorcontrib><collection>CrossRef</collection><jtitle>Neurochemical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sara T. Alrashood</au><au>Elrobh, Mohamed S.</au><au>Alamery, Salman</au><au>Odeibat, Hamza A.</au><au>Khan, Haseeb A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Short Review of Biochemical Mechanisms in Iminodipropionitrile-Induced Movement Disorder</atitle><jtitle>Neurochemical journal</jtitle><stitle>Neurochem. J</stitle><date>2020</date><risdate>2020</risdate><volume>14</volume><issue>1</issue><spage>9</spage><epage>12</epage><pages>9-12</pages><issn>1819-7124</issn><eissn>1819-7132</eissn><abstract>Iminodipropionitrile (IDPN) is a synthetic nitrile that produces permanent behavioral syndrome characterized by repetitive head movements, circling and back walking in rodents. Other synthetic nitriles of industrial importance such as crotonitrile and allylnitrile are also able to produce similar motor deficits in experimental animals. Among these nitriles, IDPN has been recognized as a prototype nitrile to be used as a positive control for behavioral testing battery. Due to the well-defined behavioral deficits and their easy quantification, IDPN-induced behavioral syndrome is a preferential animal model to test the interaction of various agents with synthetic nitriles. The mechanism of IDPN-induced dyskinesia is multifactorial. This short review focuses on the roles of neurotransmitters, oxidative stress and inflammation in the pathogenesis of IDPN-induced neurotoxicity and behavioral deficits.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1819712420010031</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1819-7124 |
| ispartof | Neurochemical journal, 2020, Vol.14 (1), p.9-12 |
| issn | 1819-7124 1819-7132 |
| language | eng |
| recordid | cdi_crossref_primary_10_1134_S1819712420010031 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Biomedical and Life Sciences Biomedicine Neurosciences Review Articles |
| title | A Short Review of Biochemical Mechanisms in Iminodipropionitrile-Induced Movement Disorder |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T17%3A06%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-crossref_sprin&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Short%20Review%20of%20Biochemical%20Mechanisms%20in%20Iminodipropionitrile-Induced%20Movement%20Disorder&rft.jtitle=Neurochemical%20journal&rft.au=Sara%20T.%20Alrashood&rft.date=2020&rft.volume=14&rft.issue=1&rft.spage=9&rft.epage=12&rft.pages=9-12&rft.issn=1819-7124&rft.eissn=1819-7132&rft_id=info:doi/10.1134/S1819712420010031&rft_dat=%3Ccrossref_sprin%3E10_1134_S1819712420010031%3C/crossref_sprin%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |