Regulation of cathepsin B and caspase-3 in long-term plasticity
It has been previously shown that high-frequency stimulation of Schaffer collaterals (HFS), which induces LTP in the CA1 area of rat hippocampus, under normal conditions results in the activation of caspase-3. In contrast to caspase-3, the activity of cathepsin B weakly decreased in hippocampal slic...
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| Veröffentlicht in: | Neurochemical journal 2009-12, Vol.3 (4), p.260-266 |
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| creator | Kudryashova, I. V. Onufriev, M. V. Kudryashov, I. E. Gulyaeva, N. V. |
| description | It has been previously shown that high-frequency stimulation of Schaffer collaterals (HFS), which induces LTP in the CA1 area of rat hippocampus, under normal conditions results in the activation of caspase-3. In contrast to caspase-3, the activity of cathepsin B weakly decreased in hippocampal slices subjected to HFS (the significance level was
p
= 0.07). This effect was observed in all slices frozen for subsequent measurements of enzymatic activity in 15 minutes and 3 hours after LTP induction under normal conditions and in the presence of caspase-3 inhibitors. The reciprocal influence of HFS, which was observed in the control slices depending on their initial state (
r
= 0.59,
p
< 0.001 in control and
r
= 0.16,
p
= 0.46 in slices subjected to HFS), complicated simultaneous measurements of the activity of these enzymes. Though the effect of HFS on cathepsin B activity is not prominent, a significant difference in LTP magnitude in slices with low and high cathepsin B activity. |
| doi_str_mv | 10.1134/S1819712409040047 |
| format | Article |
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p
= 0.07). This effect was observed in all slices frozen for subsequent measurements of enzymatic activity in 15 minutes and 3 hours after LTP induction under normal conditions and in the presence of caspase-3 inhibitors. The reciprocal influence of HFS, which was observed in the control slices depending on their initial state (
r
= 0.59,
p
< 0.001 in control and
r
= 0.16,
p
= 0.46 in slices subjected to HFS), complicated simultaneous measurements of the activity of these enzymes. Though the effect of HFS on cathepsin B activity is not prominent, a significant difference in LTP magnitude in slices with low and high cathepsin B activity.</description><identifier>ISSN: 1819-7124</identifier><identifier>EISSN: 1819-7132</identifier><identifier>DOI: 10.1134/S1819712409040047</identifier><language>eng</language><publisher>Dordrecht: SP MAIK Nauka/Interperiodica</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Experimental Articles ; Neurosciences</subject><ispartof>Neurochemical journal, 2009-12, Vol.3 (4), p.260-266</ispartof><rights>MAIK Nauka 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c218t-fc5e5255c34c1ce83b1baeff86560ef134295e3344bb2436ff96f095a69b91793</citedby><cites>FETCH-LOGICAL-c218t-fc5e5255c34c1ce83b1baeff86560ef134295e3344bb2436ff96f095a69b91793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1819712409040047$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1819712409040047$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Kudryashova, I. V.</creatorcontrib><creatorcontrib>Onufriev, M. V.</creatorcontrib><creatorcontrib>Kudryashov, I. E.</creatorcontrib><creatorcontrib>Gulyaeva, N. V.</creatorcontrib><title>Regulation of cathepsin B and caspase-3 in long-term plasticity</title><title>Neurochemical journal</title><addtitle>Neurochem. J</addtitle><description>It has been previously shown that high-frequency stimulation of Schaffer collaterals (HFS), which induces LTP in the CA1 area of rat hippocampus, under normal conditions results in the activation of caspase-3. In contrast to caspase-3, the activity of cathepsin B weakly decreased in hippocampal slices subjected to HFS (the significance level was
p
= 0.07). This effect was observed in all slices frozen for subsequent measurements of enzymatic activity in 15 minutes and 3 hours after LTP induction under normal conditions and in the presence of caspase-3 inhibitors. The reciprocal influence of HFS, which was observed in the control slices depending on their initial state (
r
= 0.59,
p
< 0.001 in control and
r
= 0.16,
p
= 0.46 in slices subjected to HFS), complicated simultaneous measurements of the activity of these enzymes. Though the effect of HFS on cathepsin B activity is not prominent, a significant difference in LTP magnitude in slices with low and high cathepsin B activity.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Experimental Articles</subject><subject>Neurosciences</subject><issn>1819-7124</issn><issn>1819-7132</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp9kNtKAzEQhoMoWKsP4F1eIJrJYbO5Ei2eoCB4uF6ycVK3bLNLkl707d1S8UbwamZ-5hv--Qm5BH4FINX1G9RgDQjFLVecK3NEZnuJGZDi-LcX6pSc5bzmXBtjxYzcvOJq27vSDZEOgXpXvnDMXaR31MXPac6jy8gknaR-iCtWMG3o2LtcOt-V3Tk5Ca7PePFT5-Tj4f598cSWL4_Pi9sl8wLqwoLXqIXWXioPHmvZQuswhLrSFccwfSCsRimValuhZBWCrQK32lW2tWCsnBM43PVpyDlhaMbUbVzaNcCbfQLNnwQmRhyYPO3GFaZmPWxTnGz-A30DUDxcVA</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Kudryashova, I. V.</creator><creator>Onufriev, M. V.</creator><creator>Kudryashov, I. E.</creator><creator>Gulyaeva, N. V.</creator><general>SP MAIK Nauka/Interperiodica</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20091201</creationdate><title>Regulation of cathepsin B and caspase-3 in long-term plasticity</title><author>Kudryashova, I. V. ; Onufriev, M. V. ; Kudryashov, I. E. ; Gulyaeva, N. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c218t-fc5e5255c34c1ce83b1baeff86560ef134295e3344bb2436ff96f095a69b91793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Experimental Articles</topic><topic>Neurosciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kudryashova, I. V.</creatorcontrib><creatorcontrib>Onufriev, M. V.</creatorcontrib><creatorcontrib>Kudryashov, I. E.</creatorcontrib><creatorcontrib>Gulyaeva, N. V.</creatorcontrib><collection>CrossRef</collection><jtitle>Neurochemical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kudryashova, I. V.</au><au>Onufriev, M. V.</au><au>Kudryashov, I. E.</au><au>Gulyaeva, N. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of cathepsin B and caspase-3 in long-term plasticity</atitle><jtitle>Neurochemical journal</jtitle><stitle>Neurochem. J</stitle><date>2009-12-01</date><risdate>2009</risdate><volume>3</volume><issue>4</issue><spage>260</spage><epage>266</epage><pages>260-266</pages><issn>1819-7124</issn><eissn>1819-7132</eissn><abstract>It has been previously shown that high-frequency stimulation of Schaffer collaterals (HFS), which induces LTP in the CA1 area of rat hippocampus, under normal conditions results in the activation of caspase-3. In contrast to caspase-3, the activity of cathepsin B weakly decreased in hippocampal slices subjected to HFS (the significance level was
p
= 0.07). This effect was observed in all slices frozen for subsequent measurements of enzymatic activity in 15 minutes and 3 hours after LTP induction under normal conditions and in the presence of caspase-3 inhibitors. The reciprocal influence of HFS, which was observed in the control slices depending on their initial state (
r
= 0.59,
p
< 0.001 in control and
r
= 0.16,
p
= 0.46 in slices subjected to HFS), complicated simultaneous measurements of the activity of these enzymes. Though the effect of HFS on cathepsin B activity is not prominent, a significant difference in LTP magnitude in slices with low and high cathepsin B activity.</abstract><cop>Dordrecht</cop><pub>SP MAIK Nauka/Interperiodica</pub><doi>10.1134/S1819712409040047</doi><tpages>7</tpages></addata></record> |
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| title | Regulation of cathepsin B and caspase-3 in long-term plasticity |
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