A short way to invert configuration of the 2,3-hydroxy groups in ecdysteroids

A short way to invert configuration of the 2,3-hydroxy groups in ecdysteroids

3- epi -2-Dehydro-20-hydroxyecdysone and its 20,22-acetonide were reduced with lithium tris( sec butyl) hydridoborate selectively at the 2-oxo group with formation of 2β,3β-dihydroxy derivatives and the corresponding 2α,3α epimers which were separated by chromatography.

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Veröffentlicht in:Russian journal of organic chemistry 2013-07, Vol.49 (7), p.995-998
Hauptverfasser: Savchenko, R. G., Kostyleva, S. A., Kachala, V. V., Khalilov, L. M., Odinokov, V. N.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Organic Chemistry
Review
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Zusammenfassung:3- epi -2-Dehydro-20-hydroxyecdysone and its 20,22-acetonide were reduced with lithium tris( sec butyl) hydridoborate selectively at the 2-oxo group with formation of 2β,3β-dihydroxy derivatives and the corresponding 2α,3α epimers which were separated by chromatography.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428013070063