Asymmetric oxidation of 4-nitro-6-trifluoromethyl-1,2,3-benzotrithiole

Asymmetric oxidation of 4-nitro-6-trifluoromethyl-1,2,3-benzotrithiole

Both enantiomers of 4-nitro-6-trifluoromethyl-1,2,3-benzotrithiole 1-oxide as analogs of Varacins B and C were synthesized for the first time. The use of the Modena method ensures higher optical purity but lower yields of the chiral sulfoxides, as compared to the Kagan procedure.

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Veröffentlicht in:Russian journal of organic chemistry 2009-09, Vol.45 (9), p.1402-1404
Hauptverfasser: Khomenko, T. M, Korchagina, D. V, Volcho, K. P, Salakhutdinov, N. F
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Organic Chemistry
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Zusammenfassung:Both enantiomers of 4-nitro-6-trifluoromethyl-1,2,3-benzotrithiole 1-oxide as analogs of Varacins B and C were synthesized for the first time. The use of the Modena method ensures higher optical purity but lower yields of the chiral sulfoxides, as compared to the Kagan procedure.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428009090140