A novel method for the synthesis of maxacalcitol
Maxacalcitol ( 1 ), a kind of active vitamin D drugs, was prepared from pregnenolone acetate ( 2 ) using a novel synthetic method including the combination of five-step organic transformations and one-step biological transformation. The new protocol was shorter, milder, and simpler than the reported...
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| Veröffentlicht in: | Russian journal of general chemistry 2016, Vol.86 (1), p.173-177 |
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| container_issue | 1 |
| container_start_page | 173 |
| container_title | Russian journal of general chemistry |
| container_volume | 86 |
| creator | Song, W.-Q. Wang, Y.-H. Liu, D.-N. Fang, W.-Z. Lu, Q. |
| description | Maxacalcitol (
1
), a kind of active vitamin D drugs, was prepared from pregnenolone acetate (
2
) using a novel synthetic method including the combination of five-step organic transformations and one-step biological transformation. The new protocol was shorter, milder, and simpler than the reported approaches. The unoptimized overall yield was 0.178%. The structure of all intermediates and final product was confirmed by
1
H NMR,
13
C NMR and MS techniques. |
| doi_str_mv | 10.1134/S1070363216010278 |
| format | Article |
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1
), a kind of active vitamin D drugs, was prepared from pregnenolone acetate (
2
) using a novel synthetic method including the combination of five-step organic transformations and one-step biological transformation. The new protocol was shorter, milder, and simpler than the reported approaches. The unoptimized overall yield was 0.178%. The structure of all intermediates and final product was confirmed by
1
H NMR,
13
C NMR and MS techniques.</description><identifier>ISSN: 1070-3632</identifier><identifier>EISSN: 1608-3350</identifier><identifier>DOI: 10.1134/S1070363216010278</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science</subject><ispartof>Russian journal of general chemistry, 2016, Vol.86 (1), p.173-177</ispartof><rights>Pleiades Publishing, Ltd. 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c288t-4661adbe966cd71b3b4a2971a150b568107623fc3a54f3e3f6b0ff5cb626cb8c3</citedby><cites>FETCH-LOGICAL-c288t-4661adbe966cd71b3b4a2971a150b568107623fc3a54f3e3f6b0ff5cb626cb8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1070363216010278$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1070363216010278$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids></links><search><creatorcontrib>Song, W.-Q.</creatorcontrib><creatorcontrib>Wang, Y.-H.</creatorcontrib><creatorcontrib>Liu, D.-N.</creatorcontrib><creatorcontrib>Fang, W.-Z.</creatorcontrib><creatorcontrib>Lu, Q.</creatorcontrib><title>A novel method for the synthesis of maxacalcitol</title><title>Russian journal of general chemistry</title><addtitle>Russ J Gen Chem</addtitle><description>Maxacalcitol (
1
), a kind of active vitamin D drugs, was prepared from pregnenolone acetate (
2
) using a novel synthetic method including the combination of five-step organic transformations and one-step biological transformation. The new protocol was shorter, milder, and simpler than the reported approaches. The unoptimized overall yield was 0.178%. The structure of all intermediates and final product was confirmed by
1
H NMR,
13
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1
), a kind of active vitamin D drugs, was prepared from pregnenolone acetate (
2
) using a novel synthetic method including the combination of five-step organic transformations and one-step biological transformation. The new protocol was shorter, milder, and simpler than the reported approaches. The unoptimized overall yield was 0.178%. The structure of all intermediates and final product was confirmed by
1
H NMR,
13
C NMR and MS techniques.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1070363216010278</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1070-3632 |
| ispartof | Russian journal of general chemistry, 2016, Vol.86 (1), p.173-177 |
| issn | 1070-3632 1608-3350 |
| language | eng |
| recordid | cdi_crossref_primary_10_1134_S1070363216010278 |
| source | SpringerNature Journals |
| subjects | Chemistry Chemistry and Materials Science Chemistry/Food Science |
| title | A novel method for the synthesis of maxacalcitol |
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