A novel method for the synthesis of maxacalcitol

A novel method for the synthesis of maxacalcitol

Maxacalcitol ( 1 ), a kind of active vitamin D drugs, was prepared from pregnenolone acetate ( 2 ) using a novel synthetic method including the combination of five-step organic transformations and one-step biological transformation. The new protocol was shorter, milder, and simpler than the reported...

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Veröffentlicht in:Russian journal of general chemistry 2016, Vol.86 (1), p.173-177
Hauptverfasser: Song, W.-Q., Wang, Y.-H., Liu, D.-N., Fang, W.-Z., Lu, Q.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
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Beschreibung
Zusammenfassung:Maxacalcitol ( 1 ), a kind of active vitamin D drugs, was prepared from pregnenolone acetate ( 2 ) using a novel synthetic method including the combination of five-step organic transformations and one-step biological transformation. The new protocol was shorter, milder, and simpler than the reported approaches. The unoptimized overall yield was 0.178%. The structure of all intermediates and final product was confirmed by 1 H NMR, 13 C NMR and MS techniques.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363216010278