Oxidation of dermatan sulfate with a NaOCl-NaBr-2,2,6,6-tetramethylpiperidine-1-oxyl reagent in an aqueous medium

The oxidation of primary hydroxyl groups in dermatan sulfate with the NaOCl-NaBr-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) reagent in an aqueous alkaline medium was carried out for the first time. Modified dermatan sulfates containing hydrated aldehyde (15-50%) and carboxyl (25-100%) groups were...

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Veröffentlicht in:	Russian journal of bioorganic chemistry 2010-05, Vol.36 (3), p.354-358
Hauptverfasser:	Ponedel'kina, I. Yu, Khaibrahmanova, E. A, Odinokov, V. N, Khalilov, L. M, Dzhemilev, U. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry dermatan sulfate Life Sciences NaOCl-NaBr-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) Organic Chemistry oxidation sodium hypochlorite
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Zusammenfassung:	The oxidation of primary hydroxyl groups in dermatan sulfate with the NaOCl-NaBr-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) reagent in an aqueous alkaline medium was carried out for the first time. Modified dermatan sulfates containing hydrated aldehyde (15-50%) and carboxyl (25-100%) groups were obtained.
ISSN:	1068-1620 1608-330X
DOI:	10.1134/S1068162010030106